ID   SSPA_SHIFL              Reviewed;         212 AA.
AC   P0ACA6; P05838;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Stringent starvation protein A;
GN   Name=sspA; OrderedLocusNames=SF3269, S3484;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Forms an equimolar complex with the RNA polymerase holoenzyme
CC       (RNAP) but not with the core enzyme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GST superfamily. HSP26 family.
CC       {ECO:0000305}.
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DR   EMBL; AE005674; AAN44733.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18544.1; -; Genomic_DNA.
DR   RefSeq; NP_709026.1; NC_004337.2.
DR   RefSeq; WP_000257293.1; NZ_WPGW01000026.1.
DR   AlphaFoldDB; P0ACA6; -.
DR   SMR; P0ACA6; -.
DR   STRING; 198214.SF3269; -.
DR   EnsemblBacteria; AAN44733; AAN44733; SF3269.
DR   EnsemblBacteria; AAP18544; AAP18544; S3484.
DR   GeneID; 1026855; -.
DR   GeneID; 67415939; -.
DR   KEGG; sfl:SF3269; -.
DR   KEGG; sfx:S3484; -.
DR   PATRIC; fig|198214.7.peg.3872; -.
DR   HOGENOM; CLU_011226_9_3_6; -.
DR   OMA; ADHYSHR; -.
DR   OrthoDB; 1997747at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   CDD; cd03186; GST_C_SspA; 1.
DR   CDD; cd03059; GST_N_SspA; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR034342; SspA_C.
DR   InterPro; IPR034341; SspA_N.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..212
FT                   /note="Stringent starvation protein A"
FT                   /id="PRO_0000185883"
FT   DOMAIN          9..87
FT                   /note="GST N-terminal"
FT   DOMAIN          92..209
FT                   /note="GST C-terminal"
SQ   SEQUENCE   212 AA;  24305 MW;  A0FFA98F7131B34F CRC64;
     MAVAANKRSV MTLFSGPTDI YSHQVRIVLA EKGVSFEIEH VEKDNPPQDL IDLNPNQSVP
     TLVDRELTLW ESRIIMEYLD ERFPHPPLMP VYPVARGESR LYMHRIEKDW YTLMNTIING
     SASEADAARK QLREELLAIA PVFGQKPYFL SDEFSLVDCY LAPLLWRLPQ LGIEFSGPGA
     KELKGYMTRV FERDSFLASL TEAEREMRLG RS