ABHEA_MOUSE
ID ABHEA_MOUSE Reviewed; 247 AA.
AC Q922Q6; Q8K4S5;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Protein ABHD14A {ECO:0000305};
DE EC=3.-.-.-;
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 14A {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 14A {ECO:0000312|MGI:MGI:1915894};
DE AltName: Full=Down-regulated in Zic-1-mutant protein;
GN Name=Abhd14a {ECO:0000312|MGI:MGI:1915894}; Synonyms=Dorz1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE
RP SPECIFICITY, AND SUBCELLULAR LOCATION.
RC STRAIN=ICR; TISSUE=Cerebellum;
RX PubMed=14667578; DOI=10.1016/j.molbrainres.2003.10.004;
RA Hoshino J., Aruga J., Ishiguro A., Mikoshiba K.;
RT "Dorz1, a novel gene expressed in differentiating cerebellar granule
RT neurons, is down-regulated in Zic1-deficient mouse.";
RL Brain Res. Mol. Brain Res. 120:57-64(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Possible role in granule neuron development.
CC {ECO:0000269|PubMed:14667578}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14667578}. Membrane
CC {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Higher expression is detected in
CC brain, kidney, heart, testis, ovary and uterus.
CC {ECO:0000269|PubMed:14667578}.
CC -!- DEVELOPMENTAL STAGE: Expressed in cerebellum during embryogenesis.
CC Highly expressed at 17.5 dpc in the cerebellar granule neurons
CC precursors. {ECO:0000269|PubMed:14667578}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD14 family.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AB073619; BAB91136.1; -; mRNA.
DR EMBL; BC006879; AAH06879.1; -; mRNA.
DR AlphaFoldDB; Q922Q6; -.
DR SMR; Q922Q6; -.
DR STRING; 10090.ENSMUSP00000126916; -.
DR ESTHER; mouse-Dorz1; CIB-CCG1-interacting-factor-B.
DR MEROPS; S33.981; -.
DR GlyGen; Q922Q6; 1 site.
DR iPTMnet; Q922Q6; -.
DR PhosphoSitePlus; Q922Q6; -.
DR PeptideAtlas; Q922Q6; -.
DR PRIDE; Q922Q6; -.
DR ProteomicsDB; 285907; -.
DR MGI; MGI:1915894; Abhd14a.
DR eggNOG; ENOG502QR0B; Eukaryota.
DR InParanoid; Q922Q6; -.
DR PhylomeDB; Q922Q6; -.
DR ChiTaRS; Abhd14a; mouse.
DR PRO; PR:Q922Q6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q922Q6; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Glycoprotein; Hydrolase; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..247
FT /note="Protein ABHD14A"
FT /id="PRO_0000282286"
FT TRANSMEM 11..31
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT ACT_SITE 147
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 198
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 225
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 227
FT /note="C -> R (in Ref. 2; AAH06879)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 27839 MW; 53586C5C42575A19 CRC64;
MVQKFMSRYQ AALLGLGLLL VFLLYMGLPG PPEQTSRLWR GPNVTVLTGL TRGNSRIFYR
EVLPIQQACR AEVVFLHGKA FNSHTWEQLG TLQLLSERGY RAVAIDLPGF GNSAPSEEVS
TEAGRVELLE RVFQDLQVQN TVLVSPSLSG SYALPFLMQN HHQLRGFVPI APTYTRNYAQ
EQFRAVKTPT LILYGELDHT LARESLQQLR HLPNHSMVKL RDAGHACYLH KPEAFHLALL
AFLDHLP
