ID   BIOC_METS6              Reviewed;         296 AA.
AC   E4QJB8;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Malonyl-[acyl-carrier protein] O-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00835};
DE            Short=Malonyl-ACP O-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00835};
DE            EC=2.1.1.197 {ECO:0000255|HAMAP-Rule:MF_00835};
DE   AltName: Full=Biotin synthesis protein BioC {ECO:0000255|HAMAP-Rule:MF_00835};
GN   Name=bioC {ECO:0000255|HAMAP-Rule:MF_00835}; OrderedLocusNames=MPQ_0592;
OS   Methylovorus sp. (strain MP688).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylovorus; unclassified Methylovorus.
OX   NCBI_TaxID=887061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MP688;
RX   PubMed=21148725; DOI=10.1128/jb.01431-10;
RA   Xiong X.H., Zhi J.J., Yang L., Wang J.H., Zhao Y., Wang X., Cui Y.J.,
RA   Dong F., Li M.X., Yang Y.X., Wei N., An J.J., Du B.H., Liang L.,
RA   Zhang J.S., Zhou W., Cheng S.F., He T., Wang L., Chen H.P., Liu D.S.,
RA   Zhang W.C.;
RT   "Complete genome sequence of the bacterium Methylovorus sp. strain MP688, a
RT   high-level producer of pyrroloquinolone quinone.";
RL   J. Bacteriol. 193:1012-1013(2011).
CC   -!- FUNCTION: Converts the free carboxyl group of a malonyl-thioester to
CC       its methyl ester by transfer of a methyl group from S-adenosyl-L-
CC       methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty
CC       acid synthetic pathway. {ECO:0000255|HAMAP-Rule:MF_00835}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl
CC         ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:17105, Rhea:RHEA-
CC         COMP:9623, Rhea:RHEA-COMP:9954, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:78449, ChEBI:CHEBI:78845; EC=2.1.1.197;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00835};
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00835}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00835}.
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DR   EMBL; CP002252; ADQ83774.1; -; Genomic_DNA.
DR   RefSeq; WP_013441397.1; NC_014733.1.
DR   AlphaFoldDB; E4QJB8; -.
DR   SMR; E4QJB8; -.
DR   PRIDE; E4QJB8; -.
DR   KEGG; mep:MPQ_0592; -.
DR   HOGENOM; CLU_046586_2_1_4; -.
DR   OMA; PSMWELM; -.
DR   UniPathway; UPA00078; -.
DR   GO; GO:0010340; F:carboxyl-O-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0102130; F:malonyl-CoA methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   HAMAP; MF_00835; BioC; 1.
DR   InterPro; IPR011814; BioC.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR02072; BioC; 1.
PE   3: Inferred from homology;
KW   Biotin biosynthesis; Methyltransferase; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..296
FT                   /note="Malonyl-[acyl-carrier protein] O-methyltransferase"
FT                   /id="PRO_0000412512"
SQ   SEQUENCE   296 AA;  32934 MW;  4E001433B7361A49 CRC64;
     MTADAYLIDK ARVRRSFDRA AGTYDAAALL QREVRERMLE RLDLVKLAPQ AVLDAGCGTG
     HASAALSARY RQSQVISLDI AMGMLKKTMA ARSLVQRLFG FDRRHAVCAD IERLPLAAAS
     IDLVWSNMAI QWCNDLDQAF GEIQRVLKPE GLLMFSTLGP DTLKELRAAT RQDNTHVTVS
     RFIDMHDIGD ALVRAGFNAP VLDVEYFELT YDDVMGVMRD LKAIGAHNAA EGRHRGLQGR
     GFLQQVQARY ESFRRDGKLP ATYEVIYGHA WKPQARVALP DGLSPVQFRP RASSST