ID   BIOC_NEORI              Reviewed;         250 AA.
AC   C6V598;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Malonyl-[acyl-carrier protein] O-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00835};
DE            Short=Malonyl-ACP O-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00835};
DE            EC=2.1.1.197 {ECO:0000255|HAMAP-Rule:MF_00835};
DE   AltName: Full=Biotin synthesis protein BioC {ECO:0000255|HAMAP-Rule:MF_00835};
GN   Name=bioC {ECO:0000255|HAMAP-Rule:MF_00835}; OrderedLocusNames=NRI_0587;
OS   Neorickettsia risticii (strain Illinois).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Neorickettsia.
OX   NCBI_TaxID=434131;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Illinois;
RX   PubMed=19661282; DOI=10.1093/nar/gkp642;
RA   Lin M., Zhang C., Gibson K., Rikihisa Y.;
RT   "Analysis of complete genome sequence of Neorickettsia risticii: causative
RT   agent of Potomac horse fever.";
RL   Nucleic Acids Res. 37:6076-6091(2009).
CC   -!- FUNCTION: Converts the free carboxyl group of a malonyl-thioester to
CC       its methyl ester by transfer of a methyl group from S-adenosyl-L-
CC       methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty
CC       acid synthetic pathway. {ECO:0000255|HAMAP-Rule:MF_00835}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl
CC         ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:17105, Rhea:RHEA-
CC         COMP:9623, Rhea:RHEA-COMP:9954, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:78449, ChEBI:CHEBI:78845; EC=2.1.1.197;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00835};
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00835}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00835}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001431; ACT69573.1; -; Genomic_DNA.
DR   RefSeq; WP_015816460.1; NC_013009.1.
DR   AlphaFoldDB; C6V598; -.
DR   SMR; C6V598; -.
DR   STRING; 434131.NRI_0587; -.
DR   EnsemblBacteria; ACT69573; ACT69573; NRI_0587.
DR   KEGG; nri:NRI_0587; -.
DR   eggNOG; COG2226; Bacteria.
DR   HOGENOM; CLU_046586_2_3_5; -.
DR   OMA; TSNFCIH; -.
DR   OrthoDB; 1739932at2; -.
DR   UniPathway; UPA00078; -.
DR   Proteomes; UP000001627; Chromosome.
DR   GO; GO:0010340; F:carboxyl-O-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0102130; F:malonyl-CoA methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   HAMAP; MF_00835; BioC; 1.
DR   InterPro; IPR011814; BioC.
DR   InterPro; IPR041698; Methyltransf_25.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF13649; Methyltransf_25; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR02072; BioC; 1.
PE   3: Inferred from homology;
KW   Biotin biosynthesis; Methyltransferase; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..250
FT                   /note="Malonyl-[acyl-carrier protein] O-methyltransferase"
FT                   /id="PRO_0000412513"
SQ   SEQUENCE   250 AA;  28417 MW;  F672926FC905AFE0 CRC64;
     MPDINNDVVA ANFSRASRSY DLVAKIQKEC CYKLVAMIRE RLPHFMPASV LDIGAGTGYL
     TKLLLSEFPN ACYTMNDISY EMLSRAREMV GESVSTILGD MSKVKFPVSD LIVSSMAIHW
     SSNPITVLKR VCRLSKVFAF SILVQPSLYE WNRLFHELSL PSPGLHYISS EEVELAMLDT
     SPTLFTWEVC NFDMRFASPK EFIRYMRQLG SNYSPAGFNA YHVRKVLKHA PGEFFSKYSV
     MFGVVSRSHF