ID   SSPN_RABIT              Reviewed;         238 AA.
AC   P82352;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Sarcospan;
GN   Name=SSPN;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle;
RX   PubMed=10189375; DOI=10.1083/jcb.145.1.153;
RA   Crosbie R.H., Lebakken C.S., Holt K.H., Venzke D.P., Straub V., Lee J.C.,
RA   Grady R.M., Chamberlain J.S., Sanes J.R., Campbell K.P.;
RT   "Membrane targeting and stabilization of sarcospan is mediated by the
RT   sarcoglycan subcomplex.";
RL   J. Cell Biol. 145:153-165(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 3-23, AND PROTEIN SEQUENCE OF 3-23 AND
RP   213-223.
RC   TISSUE=Skeletal muscle;
RX   PubMed=9395445; DOI=10.1074/jbc.272.50.31221;
RA   Crosbie R.H., Heighway J., Venzke D.P., Lee J.C., Campbell K.P.;
RT   "Sarcospan, the 25-kDa transmembrane component of the dystrophin-
RT   glycoprotein complex.";
RL   J. Biol. Chem. 272:31221-31224(1997).
CC   -!- FUNCTION: Component of the dystrophin-glycoprotein complex (DGC), a
CC       complex that spans the muscle plasma membrane and forms a link between
CC       the F-actin cytoskeleton and the extracellular matrix. Preferentially
CC       associates with the sarcoglycan subcomplex of the DGC.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       membrane, sarcolemma. Postsynaptic cell membrane. Note=Also found in
CC       myotendinous junctions and in the postsynaptic membrane of
CC       neuromuscular junctions.
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DR   EMBL; AF120276; AAD49805.1; -; mRNA.
DR   RefSeq; NP_001075519.1; NM_001082050.1.
DR   AlphaFoldDB; P82352; -.
DR   CORUM; P82352; -.
DR   STRING; 9986.ENSOCUP00000009246; -.
DR   GeneID; 100008714; -.
DR   KEGG; ocu:100008714; -.
DR   CTD; 8082; -.
DR   eggNOG; ENOG502RYPH; Eukaryota.
DR   InParanoid; P82352; -.
DR   OrthoDB; 1462432at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030429; Sarcospan.
DR   PANTHER; PTHR15260; PTHR15260; 1.
DR   Pfam; PF04103; CD20; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Membrane;
KW   Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..238
FT                   /note="Sarcospan"
FT                   /id="PRO_0000072228"
FT   TOPO_DOM        1..48
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..81
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..117
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..188
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   238 AA;  26036 MW;  8F3733F82AF0F0E5 CRC64;
     MGKDRQPRGQ QRQGDAAGPD DPGPKKGAGT REQRGEEEAQ TCCGCRFPLL LALLQLALGV
     AVTVVGFLMA SVSSSLLVRA TPYWAGIIVC VVAYLGLFML CVSYQVDERT CIQFSMKLLY
     FVLSALGLVV CVLAVAFAAH HYSLLTHLTC ENAPDSCQCK LPSSEPLSRT FVYRDVTDCT
     SITGTFQVFL LVQMVLNLVC GLVCLVACFV MWKHRYQVFY VGVRMCPLSA SEGQQQKV