SSPO_BOVIN
ID SSPO_BOVIN Reviewed; 5146 AA.
AC P98167; Q8SPM4;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=SCO-spondin {ECO:0000303|PubMed:11008217, ECO:0000303|PubMed:8743952};
DE Flags: Precursor;
GN Name=SSPO;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Subcommissural organ;
RX PubMed=11008217;
RX DOI=10.1002/1098-1136(200011)32:2<177::aid-glia70>3.0.co;2-v;
RA Gobron S.;
RT "Subcommissural organ/Reissner's fiber complex: characterization of SCO-
RT spondin, a glycoprotein with potent activity on neurite outgrowth.";
RL Glia 32:177-191(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1719-2585, FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Ependymocyte;
RX PubMed=8743952; DOI=10.1242/jcs.109.5.1053;
RA Gobron S., Monnerie H., Meiniel R., Creveaux I., Lehmann W., Lamalle D.,
RA Dastugue B., Meiniel A.;
RT "SCO-spondin: a new member of the thrombospondin family secreted by the
RT subcommissural organ is a candidate in the modulation of neuronal
RT aggregation.";
RL J. Cell Sci. 109:1053-1061(1996).
CC -!- FUNCTION: Involved in the modulation of neuronal aggregation
CC (PubMed:8743952). May be involved in developmental events during the
CC formation of the central nervous system (PubMed:11008217).
CC {ECO:0000269|PubMed:11008217, ECO:0000269|PubMed:8743952}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000269|PubMed:11008217, ECO:0000269|PubMed:8743952}.
CC -!- TISSUE SPECIFICITY: Subcommissural organ. Located at the boundary of
CC the diencephalon and mesencephalon beneath the posterior commissure at
CC the point where the axons cross the midline.
CC {ECO:0000269|PubMed:11008217, ECO:0000269|PubMed:8743952}.
CC -!- DEVELOPMENTAL STAGE: Embryo. {ECO:0000269|PubMed:8743952}.
CC -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
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DR EMBL; AJ416457; CAC94914.1; -; mRNA.
DR EMBL; X93922; CAA63815.1; -; mRNA.
DR RefSeq; NP_777131.1; NM_174706.2.
DR SMR; P98167; -.
DR STRING; 9913.ENSBTAP00000041504; -.
DR MEROPS; I08.954; -.
DR PaxDb; P98167; -.
DR PRIDE; P98167; -.
DR GeneID; 282659; -.
DR KEGG; bta:282659; -.
DR CTD; 243369; -.
DR eggNOG; KOG1215; Eukaryota.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG3538; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR InParanoid; P98167; -.
DR OrthoDB; 12226at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00112; LDLa; 9.
DR Gene3D; 2.20.100.10; -; 25.
DR Gene3D; 4.10.400.10; -; 9.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR036201; Pacifastin_dom_sf.
DR InterPro; IPR030119; SCO-spondin.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF358; PTHR11339:SF358; 6.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF01826; TIL; 11.
DR Pfam; PF00090; TSP_1; 22.
DR Pfam; PF00093; VWC; 1.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00832; C8; 3.
DR SMART; SM00041; CT; 1.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00192; LDLa; 10.
DR SMART; SM00209; TSP1; 25.
DR SMART; SM00214; VWC; 5.
DR SMART; SM00215; VWC_out; 9.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF57283; SSF57283; 1.
DR SUPFAM; SSF57424; SSF57424; 9.
DR SUPFAM; SSF57567; SSF57567; 14.
DR SUPFAM; SSF82895; SSF82895; 24.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS01209; LDLRA_1; 7.
DR PROSITE; PS50068; LDLRA_2; 9.
DR PROSITE; PS50092; TSP1; 25.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 2.
DR PROSITE; PS51233; VWFD; 3.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..5146
FT /note="SCO-spondin"
FT /id="PRO_0000186461"
FT DOMAIN 18..94
FT /note="EMI"
FT DOMAIN 185..356
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 464..519
FT /note="TIL 1"
FT /evidence="ECO:0000255"
FT DOMAIN 557..730
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 822..875
FT /note="TIL 2"
FT /evidence="ECO:0000255"
FT DOMAIN 1008..1178
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 1271..1327
FT /note="TIL 3"
FT /evidence="ECO:0000255"
FT DOMAIN 1372..1409
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1412..1447
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1448..1484
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1488..1526
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1561..1597
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1599..1638
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1652..1690
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1691..1745
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1747..1805
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1809..1865
FT /note="TIL 4"
FT /evidence="ECO:0000255"
FT DOMAIN 1821..1860
FT /note="EGF-like 1"
FT DOMAIN 1861..1898
FT /note="EGF-like 2"
FT DOMAIN 1906..1962
FT /note="TSP type-1 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1962..2022
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 2062..2220
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DOMAIN 2225..2261
FT /note="LDL-receptor class A 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2382..2418
FT /note="LDL-receptor class A 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2442..2478
FT /note="LDL-receptor class A 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2479..2532
FT /note="TSP type-1 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2534..2589
FT /note="TSP type-1 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2611..2654
FT /note="TIL 5"
FT /evidence="ECO:0000255"
FT DOMAIN 2694..2748
FT /note="TSP type-1 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2751..2807
FT /note="TSP type-1 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2809..2862
FT /note="TSP type-1 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2964..3019
FT /note="TSP type-1 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3020..3071
FT /note="TSP type-1 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3070..3122
FT /note="TIL 6"
FT /evidence="ECO:0000255"
FT DOMAIN 3163..3230
FT /note="TSP type-1 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3232..3287
FT /note="TSP type-1 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3295..3345
FT /note="TIL 7"
FT /evidence="ECO:0000255"
FT DOMAIN 3388..3450
FT /note="TSP type-1 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3452..3507
FT /note="TSP type-1 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3626..3674
FT /note="TSP type-1 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3802..3858
FT /note="TSP type-1 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3872..3924
FT /note="TSP type-1 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3938..3994
FT /note="TSP type-1 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3996..4051
FT /note="TSP type-1 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4054..4109
FT /note="TIL 8"
FT /evidence="ECO:0000255"
FT DOMAIN 4101..4168
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 4151..4204
FT /note="TSP type-1 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4245..4300
FT /note="TSP type-1 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4302..4358
FT /note="TSP type-1 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4360..4414
FT /note="TSP type-1 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4418..4473
FT /note="TIL 9"
FT /evidence="ECO:0000255"
FT DOMAIN 4610..4661
FT /note="TSP type-1 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4675..4721
FT /note="TIL 10"
FT /evidence="ECO:0000255"
FT DOMAIN 4761..4814
FT /note="TSP type-1 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4816..4870
FT /note="TIL 11"
FT /evidence="ECO:0000255"
FT DOMAIN 4983..5041
FT /note="VWFC 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 5052..5139
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 2262..2346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2327..2344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 814
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 906
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1647
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1806
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2027
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2624
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2673
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2915
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2946
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3041
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3502
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3580
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3607
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3783
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3906
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3938
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4131
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4341
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4412
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4729
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4746
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4751
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4772
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4861
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4901
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4947
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4954
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5060
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 187..317
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 209..355
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 231..237
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 559..692
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 583..729
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1010..1142
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1032..1177
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1053..1060
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1373..1386
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1380..1399
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1393..1408
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1413..1425
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1420..1438
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1432..1447
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1449..1461
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1456..1474
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1468..1483
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1489..1501
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1496..1514
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1508..1525
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1562..1574
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1569..1587
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1581..1596
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1600..1613
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1607..1626
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1620..1637
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1703..1739
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1707..1744
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1718..1729
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1907..1946
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1918..1922
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1956..1961
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2062..2220
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DISULFID 2226..2238
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2233..2251
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2245..2260
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2383..2395
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2390..2408
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2402..2417
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2443..2455
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2450..2468
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2462..2477
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2480..2516
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2491..2495
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2526..2531
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2546..2583
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2550..2588
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2561..2573
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2695..2733
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2706..2710
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2743..2747
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2763..2801
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2767..2806
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2783..2791
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2821..2856
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2825..2861
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2836..2846
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2965..3003
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2976..2980
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3013..3018
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3175..3224
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3179..3229
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3190..3214
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3244..3281
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3248..3286
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3259..3271
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3400..3443
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3404..3449
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3415..3427
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3464..3499
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3467..3506
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3477..3489
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3638..3668
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3642..3673
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3653..3658
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3814..3852
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3818..3857
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3830..3842
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3939..3975
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3950..3954
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3988..3993
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4008..4045
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4012..4050
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4023..4035
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4152..4188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4163..4167
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4198..4203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4257..4294
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4261..4299
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4272..4284
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4361..4398
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4372..4374
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4408..4413
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4611..4645
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4622..4626
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4655..4660
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4773..4808
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4777..4813
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4788..4797
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 5052..5100
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5066..5117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5076..5133
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5080..5135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 5146 AA; 543593 MW; 724C5FB8727E13DA CRC64;
MLLPALLFGA AWALANGRWC EQTETVLVEE EVTPHQEDLV PCASLQHYQR RGWRLDLTWS
GRAGLCAIYK PPETRPAAWN RTVRACCPGW GGTHCTLALA EASPEGHCFA TWLCNLGAGS
VNASAGSLEE CCAQPWGHSW RDGRSQTCHS CSNHSRLGST PSPAILQPLA GAVAQLWSQR
QRPSATCATW SGFHYRTFDG RHFHFLGRCT YLLAGAADAT WAVHLQPMGH CPQPGHCQLA
RVMMGPEEVL IRGENVTVNG RLVPEGASQL LPGLSLQWQG DWLVLSGGLG VVVRLDRSSS
VSISVDQELQ GQTQGLCGVY NGQPEDDFLE PGRGLAALAA TFGNSWRLPD SELGCLDAVE
AAQGCEDPLR GTETGTEAGQ LRAEAQDVCH QLLEGPFREC HTQVPPAEYH EACLFAYCAG
APAGSGRAER LEAVCATLAS YAQDCAARRI AVRWRKPGFC ERLCPGGQLY SDCASACPPS
CSAVGEGSEW SCGEECVSGC ECPPGLFWDG ALCVPAARCP CYRRRRRYEP GDTVRQLCNP
CECRDGRWLC AQAPCAAECA VGGDGHYVTF DGRSFSFRGR AGCRFILVQD FAKRQLLIVL
EHGDCDAGSC LHAISVSLGD TLVQLRDSGV VLVDGQDVAL PWSAAGGLSV SRASSSFLLL
RWPGARILWG VSDPAAYITL DPHHAHQVQG LCGTFTRNQQ DDFLTPAGDV ETSITAFASK
FQVAGGGTCS LEACTPLSPC STHTERQVFA EVACAILHGP TFQECHGLVD REAFHLRCLA
AVCGCTPGRD CLCPVLAAYA RRCAQEGALP SWRNQTFCPV LCPGGQEYQE CAPACDRNCG
EPEDCGELDN CVAGCNCPLG LLWDPEGQCV PPNLCPCQLG AHRYAPGSAT MKDCNHCVCQ
ERGLWNCTAH HCAPPRTFCP RELVYVPGAC LLTCDSLDAD RTCPPGSPGG CVCPPGTVLL
EERCVPPELC PCRHGGQWYL PNAAIQEDCN LCVCQGQQWH CTGQRCDGRC RASGAPHYVT
FDGLALTFPG ACEYLLVREA SGQFMVSAQN LPCGASGLTC TKALTVRLQG TVVHMLRGRA
VMVNGVSVTP PKVYSGPGLS LHTAGLFLLL STRLGLTLLW DGGTRVPVQL SPQLRGRVAG
LCGDFDGDAS NDLRSRQGVL EPTAELAAHS WRLGPLCPEP GDLPHPCAVN AHRAGWARAR
CGVVLQPLFA RCHVEVPPQQ HYEQCVYDAC GCDSGGDCEC LCSAIATYAD ECARHGIHVR
WRSQELCPLQ CERGQVYEAC GPTCPATCHD HRPEPGWPCR AVACVEGCFC PEGTLLHGGV
CLEPAACPCE WGGSFFPPGT VLQKDCGNNC TCRESQWLCG DDGGRCVEPG PGCAEGETPC
RESGHCVPHG WLCDNQDDCG DGSDEEGCAT RVCGEGQVSC CSGRCLPLVL LCDGQDDCGD
GMDEQGCPCP QDSLTCADGH CLPPARLCDG HPDCPDGADE ESCLGQVDCA PGEVSCVDGT
CLGAIQLCDG VWDCLDGGDE GPGHCPLPSL PTPPAGTLPG PSAVSWKLHL PPWPVSALRL
PCGPLDFACG SGECAPRGWR CDGEEDCADG SDESGCDRPC APHHAPCARG SHCVAAEQLC
DGVPHCPDGS DEDPGACERL QAPGGPNRTG LPCPEYSCPD GLCIGFQQVC DGQPDCELAG
TAGPSPEEQG CGAWGPWSPW ELCSRTCGPG VQGWSRRCSP PSLPVLWHCP GPERQTRACF
AAACPEDGVW TSWSRWSPCS EPCGGVTARH RECHPPQNGG RTCATLPGGP PSTRETRPCP
QDGCPNVTCS GELVFHACVP CPLTCDDISG QATCPPDRPC GGPGCWCPAG QVLGAQGRCV
WPRQCPCLVD GSRYWPGQRV KTDCQLCVCQ DGRPRRCQPS LDCAVNCGWS AWSPWAECLG
PCGSRSVQWS FRSPNNPRPA GRGHQCRGLH RKARRCQTEP CEGCEQDGRV HRVGERWRAG
PCRVCQCLHD GSARCSPYCP LGSCPQDWVL VEGVGESCCH CVPPGENQTV HPMATPVPAP
TPSPQIGAPL ITYLLPPPGD PCYSPLGLAR LPEGSLPASS QQLEHPAWAA ILRPAPGAPG
WSPVEHADTQ GHTPPPYLQL DLLQPRNLTG IIVQGAGSSD WLQVSSDGLH WHSYRDIQHG
TQPAPQLFPK NWNGPSTVWM FARMVQARHV RVWPSDGHHQ AAPSSDANLD GPLRVELLGC
EPAPLCLGVG HRCVSGECAP RGAPCDGVED CKDGSDEEGC VTPPAGAGRI ESTAWSSAPS
SAQPGQLPPQ PSEGLAEAEA DHWHPGRGSP VPPTGKGPAS LGSEPHPSPG GSVQTVTPTS
QPEAQALRPE MAAVTVLPPH PMVTPEVPAG RSTTPGPFPH VQCSPGQVPC EVLGCVELEQ
LCDGREDCLD GSDERPCAWA AGTVPFTVPT TTLPGLPASR DLCSPSQLTC GSGECLPVER
RCDLQLDCQD GSDENGCVDC GLAPWSGWSS CSRSCGLGLA FQRRELLRPP LPGGSCPPDR
LRSQPCFVQA CPVAGAWAEW EAWGPCSVSC GGGHRSRRRS CMDPPPKNGG APCPGPPQER
APCGLQPCAG GTDCGQGRVH VSAELCRKGL VPPCPPSCLD PEANRSCSGL CLEGCRCPPG
LLLQDAGCLP LSECPCLVGE ELQQPGVPFL LDNCSRCVCE KGALLCEPGG CPVPCGWSAW
SSWGPCDRSC GSGLRARFRS PSNPPAASGG APCEGQRQEL QACYSACGAE VPGWTPWAPW
SACSQSCLVP GGGPALRSRS RLCPGPGDTS CIGEATEEEP CSPPVCLGLG VWGQWAAWSA
CSAPCNGGVQ TRGRRCSASA PGDPGCQGPH SQTRDCNTQP CTAQCPGDMV FRSAEQCRWE
GGPCPGLCLA RGPGVECTGV CTAGCACPTG LFLHNSSCLP PSQCPCQLRG QLYAPGAVAR
LDSCSNCTCI SGEMVCASEP CPVACGWSPW TPWSLCSRSC NVGVRRRFRA GTAPPAAFGG
AACQGPNMEA EFCSLRPCGG PAGEWGPWSP CSVPCGGGYR NRTRGSSGPS PVDFSTCGLQ
PCAGPAPGVC PPGKRWLDCA QGPASCAELS APRGADQPCH PGCYCPSGML LLNNACVPTQ
DCPCTHGGRL HPPGSAVLRP CENCSCVSGL ITNCTSWPCK EGQPTWSPWT PWSECSASCG
PARRHKHRFC TRPPGGAPSS MAPPLLLSSV PPLCPGPEAE EEPCLLPECD RAGGWGPWGP
WSSCSRSCGG GLRSRSRACD QPPPQGLGDY CEGPRAQGAA CQALPCPVTN CTAIEGAEYS
ACGPPCPRSC DDLVHCVWHC QPGCYCPPGQ VLSADGTVHV QPGHCSCLDL LTGERHRPGA
QLAKPDGCNY CTCSEGQLTC TDLPCPVPGA WCPWSEWTAC SQPCQGQTRT RSRACSCPAP
QHGGAPCPGE AGEAGAQHQR ETCASTPECP VDGAWSPWGP WSPCEVCLGR SHRSRECSWP
PTSEGGRPCP GGHRQSRPCQ GNSTQCTDCA GGQDLLPCGQ PCPRSCEDLS PGVECQPDSM
GCQQPRCGCP PGQLSQDGLC VTPSQCRCQY QPGAMGIPEN QSRSAGSGLS SWESLEPGEV
VTGPCDNCTC VAGILQCQEV PACSGLGLWG SWGPWEDCSV SCGGGEQLRF RRCPRPPCPG
PARQSRTCRT QVCREAGCPA GRLYRECQPS EGCPFSCAHV TGQVGCFSAG CEEGCHCPEG
TFLHRSACVQ ECPCVLTALW LQGLGAAGAD PGAHLSVLGE NGQPLGPGDE LGSGQSLRTG
CHNCSCAHGK LSCSVEACSK AAGGFSPWGP WGPCSRSCGG LGTRTRSRQC VRPMPAPGGQ
GCHGPHWDLE YCPSPECPGA AGSTAEPATG LPGGWGLWSP WSPCSGTCTD PAHPAWRSRS
RLCLANCTGG AASQERPCNL PSCTELPLCP GPGCEAGNCS WTAWAPWEPC SRSCGVGQQR
RLRAYHPPGP GGHWCPDVLT AYQERRFCNL RACPVPGGWS RWSPWSWCDR SCGGGRSLRS
RSCSSPPPKN GGAPCVGERH HARLCNPTPC EEGCPAGMEV VSCANRCPRR CSDLQEGIVC
QEDQACQQGC RCPEGSLEQD GGCVPLGHCE CTDAQGHSWA PGSQHQEACN NCTCRAGQLS
CTAQPCPPPA HCAWSRWSAW SPCSRSCGPA GQQSRFRSST SGSWAPECRE EQSQSQPCPQ
SPCPPLCLQG TRPRSLGDSW LQDGCQQCSC TPEGIICEDA ECAGLGAWTP WSPWSDCPVS
CGGGNQVRTR VCVASAPPRG GSPCLGPDVQ SQRCGLWPCP ALPDTCSWGP WGPCSRSCGP
GLASRSASCP CLLAEAEPAC NSTSPRLDTQ ACYAGPCLEE CVWSSWSSWT RCSCEVLVQQ
RYRHQRPAPG GAGAGPPCTR LDGHFRPCLT GNCSEDSCAP PFEFQACGSP CTGLCATYLS
PWLCQDLPPC QPGCYCPEGL LEQAGGCVPP EQCNCQHVSG EGAGVTLAPG DRLQLGCKEC
ECQRGELQCT SQGCQGLLPL SGWSEWSPCG PCLPLGLLAP ASRAALEERW PQDTAGLSPT
SAPTLASEQH RHRLCLDPET GRPWAGDPDL CTVPLSQQRL CPDPGACQDL CQWGPWGAWS
PCQVPCSGGF RLRWREAGIP PGGGCRGPWA QTESCNMGPC PGESCEAQDT VPTPDCANQC
PRSCVDLWDR VECLQGPCRP GCRCPPGQLV QDGHCVPVSS CRCGLPSPNA SWALAPAEVV
RLDCRNCTCV NGSLACSSHE CPTLGPWSAW SNCSAPCGGG TTKRHRSCKE GPGVTPCQAQ
DMEQQQDCNL QPCPECPPGQ VLSACAVSCP RLCSHLQPGT PCMQEPCQLG CDCPRGQLLH
NGTCVPPAEC PCTQLSLPWG LTLTLEEQHR ELPPGTLLTQ NCTHCICQGG AFSCSLTDCQ
ECPPGETWQQ VAPGELGPCE QTCREPNATE TQGNCSGRQA PGCVCQRGHF RSQEGPCVPV
DLCECWHHGR PHPPGSEWQK ACESCRCVSG ESICTQHCPP LTCAQGETAV QEPGGCCPTC
RQEAPEEQPV SCRHLTELRN LTKGACYLEQ VEVNYCSGHC PSSTNVLPEE PYLQSQCDCC
SYRLDPENPV RILNLRCPGG RTELVVLPVI HSCQCSACQG GDFSER
