SSPO_CHICK
ID SSPO_CHICK Reviewed; 5255 AA.
AC Q2PC93;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=SCO-spondin;
DE Flags: Precursor;
GN Name=SSPO;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=CNS;
RA Didier R.;
RT "Characterization of SCO-spondin in chick embryos.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the modulation of neuronal aggregation (By
CC similarity). May be involved in developmental events during the
CC formation of the central nervous system (By similarity).
CC {ECO:0000250|UniProtKB:P98167}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:P98167}.
CC -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ866919; CAI29216.1; -; mRNA.
DR RefSeq; NP_001006351.2; NM_001006351.2.
DR SMR; Q2PC93; -.
DR STRING; 9031.ENSGALP00000007857; -.
DR PaxDb; Q2PC93; -.
DR GeneID; 420367; -.
DR KEGG; gga:420367; -.
DR CTD; 243369; -.
DR VEuPathDB; HostDB:geneid_420367; -.
DR eggNOG; KOG1215; Eukaryota.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG3611; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR InParanoid; Q2PC93; -.
DR OrthoDB; 12226at2759; -.
DR PhylomeDB; Q2PC93; -.
DR PRO; PR:Q2PC93; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00112; LDLa; 12.
DR Gene3D; 2.20.100.10; -; 24.
DR Gene3D; 4.10.400.10; -; 13.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR030119; SCO-spondin.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF358; PTHR11339:SF358; 12.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00057; Ldl_recept_a; 12.
DR Pfam; PF01826; TIL; 12.
DR Pfam; PF00090; TSP_1; 25.
DR Pfam; PF00093; VWC; 1.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00832; C8; 3.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00192; LDLa; 13.
DR SMART; SM00209; TSP1; 27.
DR SMART; SM00214; VWC; 9.
DR SMART; SM00215; VWC_out; 11.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF57424; SSF57424; 12.
DR SUPFAM; SSF57567; SSF57567; 15.
DR SUPFAM; SSF82895; SSF82895; 25.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS01209; LDLRA_1; 11.
DR PROSITE; PS50068; LDLRA_2; 13.
DR PROSITE; PS50092; TSP1; 27.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 2.
DR PROSITE; PS51233; VWFD; 3.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..5255
FT /note="SCO-spondin"
FT /id="PRO_0000245045"
FT DOMAIN 19..111
FT /note="EMI"
FT DOMAIN 192..358
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 453..508
FT /note="TIL 1"
FT /evidence="ECO:0000255"
FT DOMAIN 508..601
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 546..717
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 809..868
FT /note="TIL 2"
FT /evidence="ECO:0000255"
FT DOMAIN 868..926
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 998..1168
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 1263..1319
FT /note="TIL 3"
FT /evidence="ECO:0000255"
FT DOMAIN 1362..1398
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1400..1436
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1439..1477
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1479..1515
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1515..1551
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1555..1593
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1616..1652
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1654..1693
FT /note="LDL-receptor class A 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1699..1734
FT /note="LDL-receptor class A 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1748..1790
FT /note="LDL-receptor class A 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1789..1843
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1845..1903
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1907..1961
FT /note="TIL 4"
FT /evidence="ECO:0000255"
FT DOMAIN 1919..1956
FT /note="EGF-like 1"
FT DOMAIN 1957..1983
FT /note="EGF-like 2"
FT DOMAIN 1961..2019
FT /note="VWFC 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 2002..2058
FT /note="TSP type-1 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2058..2120
FT /note="VWFC 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 2162..2310
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DOMAIN 2327..2362
FT /note="LDL-receptor class A 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2481..2517
FT /note="LDL-receptor class A 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2538..2574
FT /note="LDL-receptor class A 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2575..2628
FT /note="TSP type-1 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2630..2685
FT /note="TSP type-1 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2708..2750
FT /note="TIL 5"
FT /evidence="ECO:0000255"
FT DOMAIN 2790..2844
FT /note="TSP type-1 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2849..2903
FT /note="TSP type-1 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2905..2958
FT /note="TSP type-1 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2971..3020
FT /note="TIL 6"
FT /evidence="ECO:0000255"
FT DOMAIN 3020..3077
FT /note="VWFC 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 3060..3115
FT /note="TSP type-1 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3117..3158
FT /note="TSP type-1 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3165..3217
FT /note="TIL 7"
FT /evidence="ECO:0000255"
FT DOMAIN 3217..3275
FT /note="VWFC 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 3258..3309
FT /note="TSP type-1 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3410..3475
FT /note="TSP type-1 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3477..3532
FT /note="TSP type-1 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3534..3589
FT /note="TIL 8"
FT /evidence="ECO:0000255"
FT DOMAIN 3644..3700
FT /note="TSP type-1 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3702..3751
FT /note="TSP type-1 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3878..3934
FT /note="TSP type-1 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3951..4004
FT /note="TSP type-1 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4018..4074
FT /note="TSP type-1 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4076..4131
FT /note="TSP type-1 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4134..4189
FT /note="TIL 9"
FT /evidence="ECO:0000255"
FT DOMAIN 4230..4282
FT /note="TSP type-1 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4322..4384
FT /note="TSP type-1 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4386..4433
FT /note="TSP type-1 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4437..4492
FT /note="TIL 10"
FT /evidence="ECO:0000255"
FT DOMAIN 4537..4608
FT /note="TSP type-1 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4610..4662
FT /note="TSP type-1 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4675..4722
FT /note="TIL 11"
FT /evidence="ECO:0000255"
FT DOMAIN 4762..4815
FT /note="TSP type-1 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4817..4869
FT /note="TSP type-1 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4872..4926
FT /note="TIL 12"
FT /evidence="ECO:0000255"
FT DOMAIN 4979..5033
FT /note="TSP type-1 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 5092..5150
FT /note="VWFC 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 5161..5248
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 2352..2373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3932..3951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 801
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 931
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 972
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1340
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1610
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1652
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1713
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1743
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1856
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2230
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2746
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3011
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3042
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3065
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3238
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3350
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3366
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3392
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3598
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3625
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3823
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3869
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4018
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4211
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4362
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4428
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4498
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4730
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4747
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4752
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4867
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4939
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4970
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5081
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 194..317
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 216..357
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 548..681
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 570..716
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 592..600
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1000..1132
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1022..1167
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1043..1050
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1363..1376
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1370..1389
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1383..1397
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1401..1413
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1408..1426
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1420..1435
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1440..1452
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1447..1465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1459..1476
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1480..1492
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1487..1505
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1499..1514
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1516..1528
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1523..1541
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1535..1550
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1556..1568
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1563..1581
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1575..1592
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1617..1629
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1624..1642
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1636..1651
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1655..1668
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1662..1681
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1675..1692
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1700..1711
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1706..1724
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1718..1733
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1749..1759
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1754..1772
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1766..1789
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1801..1837
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1805..1842
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1816..1827
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1857..1897
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1861..1902
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1871..1881
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2003..2042
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2014..2018
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2052..2057
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2162..2310
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DISULFID 2328..2339
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2335..2352
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2346..2361
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2482..2494
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2489..2507
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2501..2516
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2539..2551
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2546..2564
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2558..2573
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2576..2612
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2587..2591
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2622..2627
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2642..2679
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2646..2684
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2657..2669
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2791..2829
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2802..2806
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2839..2843
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2861..2897
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2865..2902
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2881..2887
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2917..2952
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2921..2957
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2932..2942
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3061..3099
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3072..3076
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3109..3114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3270..3303
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3274..3308
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3285..3293
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3422..3468
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3426..3474
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3437..3449
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3489..3524
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3492..3531
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3502..3514
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3656..3693
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3660..3699
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3671..3683
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3714..3745
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3718..3750
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3729..3735
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3890..3928
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3894..3933
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3906..3918
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3963..3998
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3967..4003
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3982..3988
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4019..4055
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4030..4034
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4068..4073
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4088..4125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4092..4130
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4103..4115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4231..4266
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4242..4246
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4276..4281
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4387..4417
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4398..4400
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4427..4432
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4548..4601
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4551..4607
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4575..4591
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4611..4646
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4622..4626
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4656..4661
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4774..4809
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4778..4814
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4789..4798
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4818..4852
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4829..4833
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4863..4868
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4980..5017
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4991..4995
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 5027..5032
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 5161..5209
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5175..5226
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5185..5242
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5189..5244
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 5255 AA; 560556 MW; DBE892EA9AA0378B CRC64;
MGIVATVLLW VVTEAARGRW CERTEQVTEE EVVMPRREDV VPCPSMYQYS LAGWRIDLNR
MRQVYGGERG VPPTSTHPGA AMCYIYRPPE TQLVVRNRTV RACCAGWSGP HCTEVEGSLG
QCHASWQCQD ALGAHNLSTV SMAECCRQPW GHSWRNGSSA LCFACSRQPL TGDVPLPTAP
RGPAARHRGP TASCTVWAGS RYRSFDGRHF GFQGECAYSL AASTDSTWAV SITPGSPPVL
HMTFGLDTVV AQGHNISVNG VAVPEGRQHL HGGISVTWLG DFVAVESGLG VHLKLDGRGT
VYVTVSAELR GSTKGLCGPY NDDPIDDFLR VEGDVAPLAA SFGNSWRIPD ANPELSCSDA
VEPSPGCAMG STAQRAAEAM CGMLLTDPFR QCHEAVDPHG FYEACLELHC REGGTGPSPP
PAVCDTLATY VRDCAQRRAY IEWRRPGLCE QQCGHGQRYS DCVSSCPASC MAAGTAEEGH
CRDDCASGCE CTPGLLLDRG ACIPQSACPC LHRGHIYAPG QSIRQRCNQC TCRGGRWLCT
QDRCAAECAV LGDLHYITFD RRRFSFPGAC EYTLVQDFVE GTLRITAEQE ACGGHQPLSC
LRALSITVPG ASARLHSTGE VVVDGRVVPL PFASAALTVR RASSSFLLLQ TFGAHLLWGL
ETPAAYITLQ PAFANKVRGL CGTYNWDQRD DFATPAGDVE VGVTAFANKY RVSTDCPVLS
PVPFEPCSTY APRRELAAAA CAILHGASFQ PCHHLVDREP FHQLCLYDVC ACPAGKHCLC
PALAAYAREC AQEGAALSWR NESFCGTQCR GGQVYQECSS PCGRTCADLR LDGASSCPSL
DNICVSGCNC PEGPVLDDGG QCVPPGVCPC QHSSQLYPAG SKIRQGCNAC MCTAGTWSCT
DAPCPDAAFC PGDLVYVFGS CLRTCDSAEP NGTCTGIADG CVCPPGTVFL DERCVPPEEC
PCQHNGRLYH PNDTIVRDCN TCVCRQQRWQ CSSEDCMGTC VATGDPHYIT FDGRAFSFLG
DCEYVLVREA NGLFTVTAEN VPCGTSGVTC TKSVVVEMGN TVVHMLRGRD VTVNGVSVRP
PKVYSGNGLT LQRAGIFLLL LSRLGLAVLW DGGTRVYIRL QPQHRGRVVG LCGNFDRDAE
NDLASQQGVL EPTAELFGNS WRVSLLCPEV DGTTAQHPCT DNPHRATWAR KRCSILTQRL
FAPCHDEVPC QHFYDWCIFD ACGCDSGGDC ECLCTAIATY AEECSQRGIH IRWRSQDLCP
MQCDGGQEYS ACGPPCPQTC RNLGLELPEH CDTMSCLEGC FCPEGKVLHE GSCIDPAECP
CFWQGIAFPD SAVVQQGCRN CSCTAGLWQC VPTAEPCPAQ PHCPDSEFPC RSGGRCVPGA
WLCDNEDDCG DGSDEVCALH CAPHQHRCAD GQCVPWGARC DGLSDCGDGS DERGCPPPPC
APPEFRCASG RCIPRAHVCN GELDCGFADD SDEAGCSPSC SVGEFQCAAG RCVPYPHRCN
GHDDCGDFSD ERGCVCPAGH FQCPDAQCLP PAALCDGMQD CGDGTDEAFC PDRITCAPGQ
LPCPDGSCVS QVKLCDGIWD CRDGWDESSV RCMVSWAPPA PTQLPTVPAN GTAAPVCGPY
EFPCRSGQCV PRGWVCDSEA DCPDNSDELG CNRSCVLGHF PCALGAHCIH YDHLCDGIPH
CPDHSDESDD NCGSTQIPPC PGHFVCNNRV CVNATRVCDG ALDCPQGEDE LACEGYVPTG
ERNQTVGPCA EYSCRDGDCI TFKQVCNGLP DCRDGDMASG WLPSDEWDCG QWGPWAPWGI
CSHSCGLGQQ LRARECSQRT PGVLHQCHGE ATQARPCFST ACPVDGAWSE WTMWSNCTQG
CEGVVVRQRH CQPPRDGGRP CAALPATAHA TLEIGTCQQD GCPPASCPGG LQPRPCAPCP
ASCADLASRA PCRREQCTPG CWCAEGLVLD GERGCVRPRE CRCEVDGLRY WPGQRMKLNC
RLCTCLDGQP RRCRHNPACS VSCSWSAWSP WGECLGPCGV QSIQWSFRSP SHPGKHGTNR
QCRGIYRKAR RCQTEPCQEC EHQGRSRAQG DRWRWGPCHV CQCLPGPEVR CSPYCARSAV
GCPQGQVLVE GKGDSCCFCA QIGDNVTAIP TALTMEPPST MPGEPSDSPL PTFPLPSPGD
PCYSPLGIAS LPDSSFTASA EQQQHPARAA RLHHVSPGLE LQGWAPPADT VPGLPSHLPF
LQLDLLQTTN LTGVVVQGAG AGDAFITAFQ LQFSTDGNRW HNYQQLFQGN WDATTPVVQP
LDHMVQARYI RILPQGFHNA IFLRAELLGC PTVPLDLAVT TAVTPAPCGT GEFWCGVSCV
TASRRCDGAT DCPGGADEAG CEPPSSTTLP THPASLTTPG SAGILGLTAE PPVAPPAAVP
EGTSAWLTVG STSPAVPSTT GLPGVPTATI TPRGPPSAGP PSPGMAAVTV SHPVMGPPAL
PMPPTGVPTP TSAEPPLPRL LCPPDQFLCD ALGCVDAAMV CDGQQDCLDG SDEAHCGALP
TSGSSPSPLA WPSSPPPTCS PKQFSCGTGE CLALEKRCDL SRDCADGSDE SSCADCILSP
WGGWSQCSHS CGLGVTSRQR VLLRGALPGG TCHTPRLDTR ACFLRACPVP GAWAAWGVWS
SCDAECGGGM RSRTRSCTDP PPKNGGQPCA GEALQSQPCN LQPCGDTREC GPGMVLVQEG
DCVQGLVPPC PQVCGDLSAT SSCQSPCQEG CRCPPGLFLQ EGTCVNASQC HCHQGQQRWL
PSQVFLRDGC SQCVCRDGVV TCEDTACPIA CAWSAWSLWT LCDRSCGVGM QERFRSPSNP
AAANGGAPCD GDTREVRECH TPCATAEPSS GWSSWTPWSP CSRSCFHHVD QRGRRHRFRH
CEGMGTCPGL GVQEEPCDTA PCPVAGVWMP WSAWSECSAP CDAGVQTRSR TCTPPAFGGA
ECTGPHLQTR NCNTRPCGAQ CPDTMQYLTA EECRHSEGRC PWICQDLGAG VACTAQCQPG
CHCPAGLLLQ NGTCVPPSHC LCHHRGHLYQ PGDINALDTC NNCTCVTGQM VCSTETCPVP
CTWSNWTAWS TCSHSCDVGM RRRYRVPIVP PLAGGGPPCQ GPSMEVEFCS LQPCRAVAPW
GPWSECSVSC GGGYRNRTRD GPPLHSLEFS TCNPAPCPGK EPGVCPPGKQ WQACAQGAAS
CAELSAAPPA DGSCHPGCYC PPGALLLNNE CVAEAACPCA VDGVLYQPGD VVPQGCHNCS
CIAGRVTNCS QEDCGDVDGP WTPWTPWSEC SASCGPGRQR RYRFCSAHPG VPCAEPQPQE
RPCARQPCHS PDCAAVPGSV FSHCRPPCPR SCDDISHCVW HRQPGCYCTN GTLLDATGTA
CVALENCTCL DAHSGQRHQP GQSVPRGDGC NNCTCTQGRL LCTGLPCPVP GAWCEWSPWT
PCSRSCGDEA ATRHRVCSCP APQQGGAGCP GGLEGHGDTG MQLQHQECPS VPPCPEDGAW
AAWGPWSGCG GCGGQAVRTR SCSSPPARFG GLPCAGEARQ SRACPWATSS CPECAGGLVA
FTCGKPCPHS CEDLREDTAC MATPRCLPAC ACPHGQLLQD GDCVPPELCR CAWAPSKNGS
IWEQDGAVPM QELQPGETVQ RHCQNCTCKS GTLQCHAEPG CRADGGWSPW GPWSPCSPGC
QAGTQLASRQ CNNPTPQLGG RGCSGHSQRQ RPCPATEGCP EEEPWGEWSP WGPCSASCGG
GEQLRHRDCP PPGGCPGLAL QSKTCNTHVC REAGCPPGRL YRECQQGEGC PYSCAHLAGR
IACFPGGCQE GCHCPTGTLL HHGHCLQECP CVLTAEVLRK LRNSSADLQA APHLLGTRGP
PLALDQELPP GSTIHSACTS CTCLHGRLNC SEPVCPRDGG FSPWGPWSSC SRSCGGLGVM
TRRRGCTNPE PARGGRDCAG PRSDSKYCQS PECPAVPTTE PGPGVAGAEE EEGFGPWSPW
SPCSKTCTHP ERPATKTRER PCVGTAVCSG DGFQEQPCNL PLCSDVPPCQ GEDCAGLNCS
WAPWGPWTEC SRSCGVGRQQ RLRAYSPPGA SGRWCPGILS AFVQRRFCSL QACKVDGAWS
AWSPWSRCDR TCGGGRAVRT RSCTRPPPKN GGQRCPGERH QLHLCNAQPC DDSCPPGMAL
VTCANHCPRH CGDLQEGIVC REEEHCEPGC RCPNGTLEQD GGCVPLAHCE CTDAQGHGWV
PGSTHHDGCN NCTCLEGRLR CTDRLCPPLR CPWSRWSRWS PCSVTCGDGQ QTRFRTPTAG
SWDEECQGEQ MENRGCAAGP CPPLCPQGSW ERRLGDMWLQ GECQRCTCTP EGTVCEDTTC
AGAEHCTWGT WSPCSRSCGT GLASREGSCP CPFPGPPGAV CNASTGDGAR PHREVQACYL
RPCPAECSWS AWSSWGGCSC SSPLQHRYRH RHGTGLCVGL DVELHPCNTS GCSESSCEPP
FEFQPCSPPC ARLCSTLQHP ELCPAQSHCL PGCFCPQGLL EQRSACVPPE QCDCLHTNES
GDLVTLSPGD IILLGCKECV CQDGALQCSS EGCQGLLPLS PWSEWTPCST CLPLFPSHLG
DATPHVSVQH RYRACLDPQS GQPWSGDTAV CSAELQQQRL CPDPDICQEL CLWSPWGPWG
PCQQPCSGSF RLRHRHLQRL AGSGQCQGAQ TQSESCNTAV CPGEDCEKQG RVFATTCANS
CPRACADLWQ HVECVQGGCK PGCRCPQGQL LQDGLCVPTA QCRCGLSGDN GTQELWPGQE
ATIECHNCTC ENGTMVCPAL PCPSYGPWST WSPCSSSCGS GRTSRHRTCE PNPGGVPCMA
SGMQETAECS PQPCPAGCQL SPWSPWSPCS SSCGGGRSER SRELLGGEEE PCPIPALRQH
RVCNVHNCTQ ECPRSQVHRE CANACPHACA DLRPQTQCLP QPCQPGCACP PGQVLQDGAC
VPPEECRCTL DSTMPGVLNL SREEQEQEHA PGSRLQHRCN TCICIRGTFN CSQEECNVDC
LWSPWSPWSP CSVTCGMGER LSHRHPLRQR LYEGAECLGP PVRRAACHLP DCACPEGERW
QGHEVPPGCE QSCRDILDET PANCTPSPSP GCTCEPGHYR NSSGHCVPST LCECLHQGQL
HQPGSEWQEQ CARCRCVDGK ANCTDGCTPL SCPEGEVKVR EPGRCCPVCR MEWPEEPSSM
CRRFTELRNI TKGPCSLPNV EVSFCSGRCP SRTAVTPEEP YLQTLCECCS YRLDPGSPVR
ILSLPCAGGA AEPVVLPIIH SCECSSCQGG DFSKR
