SSPO_HUMAN
ID SSPO_HUMAN Reviewed; 5150 AA.
AC A2VEC9; A0A096LNW2; Q76B61;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=SCO-spondin {ECO:0000305};
DE AltName: Full=SCO-spondin pseudogene {ECO:0000312|HGNC:HGNC:21998};
DE Flags: Precursor;
GN Name=SSPOP {ECO:0000312|HGNC:HGNC:21998}; Synonyms=KIAA2036, SSPO;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP IDENTIFICATION (ISOFORM 1).
RX PubMed=17126404; DOI=10.1016/j.brainresrev.2006.09.007;
RA Meiniel O., Meiniel A.;
RT "The complex multidomain organization of SCO-spondin protein is highly
RT conserved in mammals.";
RL Brain Res. Brain Res. Rev. 53:321-327(2007).
RN [4]
RP ANALYSIS OF TSP TYPE-1 DOMAINS.
RX PubMed=30520531; DOI=10.1002/prot.25640;
RA Stoddard S.V., Welsh C.L., Palopoli M.M., Stoddard S.D., Aramandla M.P.,
RA Patel R.M., Ma H., Beck L.H. Jr.;
RT "Structure and function insights garnered from in silico modeling of the
RT thrombospondin type-1 domain-containing 7A antigen.";
RL Proteins 87:136-145(2019).
RN [5]
RP VARIANTS TRP-1002 AND CYS-2799.
RX PubMed=26477546; DOI=10.1016/j.ajhg.2015.09.009;
RG Care4Rare Canada Consortium;
RA Srour M., Hamdan F.F., McKnight D., Davis E., Mandel H.,
RA Schwartzentruber J., Martin B., Patry L., Nassif C., Dionne-Laporte A.,
RA Ospina L.H., Lemyre E., Massicotte C., Laframboise R., Maranda B.,
RA Labuda D., Decarie J.C., Rypens F., Goldsher D., Fallet-Bianco C.,
RA Soucy J.F., Laberge A.M., Maftei C., Boycott K., Brais B., Boucher R.M.,
RA Rouleau G.A., Katsanis N., Majewski J., Elpeleg O., Kukolich M.K.,
RA Shalev S., Michaud J.L.;
RT "Joubert Syndrome in French Canadians and Identification of Mutations in
RT CEP104.";
RL Am. J. Hum. Genet. 97:744-753(2015).
CC -!- FUNCTION: Involved in the modulation of neuronal aggregation (By
CC similarity). May be involved in developmental events during the
CC formation of the central nervous system (By similarity).
CC {ECO:0000250|UniProtKB:P98167}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:P98167}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2VEC9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2VEC9-2; Sequence=VSP_035258, VSP_035259, VSP_035260,
CC VSP_035261, VSP_035262, VSP_035263;
CC -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC98376.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB111888; BAC98376.1; ALT_INIT; mRNA.
DR EMBL; AC004877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF495712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BN000852; CAJ43920.1; -; mRNA.
DR RefSeq; NP_940857.2; NM_198455.2.
DR SMR; A2VEC9; -.
DR BioGRID; 116762; 5.
DR IntAct; A2VEC9; 1.
DR TCDB; 9.B.87.1.18; the selenoprotein p receptor (selp-receptor) family.
DR GlyGen; A2VEC9; 43 sites.
DR iPTMnet; A2VEC9; -.
DR PhosphoSitePlus; A2VEC9; -.
DR BioMuta; SSPO; -.
DR jPOST; A2VEC9; -.
DR PeptideAtlas; A2VEC9; -.
DR PRIDE; A2VEC9; -.
DR ProteomicsDB; 545; -. [A2VEC9-1]
DR GeneCards; SSPOP; -.
DR HGNC; HGNC:21998; SSPOP.
DR MIM; 617356; gene.
DR neXtProt; NX_A2VEC9; -.
DR InParanoid; A2VEC9; -.
DR OrthoDB; 12226at2759; -.
DR PhylomeDB; A2VEC9; -.
DR PathwayCommons; A2VEC9; -.
DR Reactome; R-HSA-5083635; Defective B3GALTL causes PpS.
DR Reactome; R-HSA-5173214; O-glycosylation of TSR domain-containing proteins.
DR SignaLink; A2VEC9; -.
DR BioGRID-ORCS; 23145; 7 hits in 202 CRISPR screens.
DR ChiTaRS; SSPO; human.
DR GeneWiki; SSPO; -.
DR GenomeRNAi; 23145; -.
DR Pharos; A2VEC9; Tdark.
DR PRO; PR:A2VEC9; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A2VEC9; protein.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProt.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:UniProt.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00112; LDLa; 9.
DR Gene3D; 2.20.100.10; -; 23.
DR Gene3D; 4.10.400.10; -; 9.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR036201; Pacifastin_dom_sf.
DR InterPro; IPR030119; SCO-spondin.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF358; PTHR11339:SF358; 6.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF01826; TIL; 12.
DR Pfam; PF00090; TSP_1; 22.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00832; C8; 3.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00192; LDLa; 10.
DR SMART; SM00209; TSP1; 25.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 9.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF57283; SSF57283; 1.
DR SUPFAM; SSF57424; SSF57424; 10.
DR SUPFAM; SSF57567; SSF57567; 14.
DR SUPFAM; SSF82895; SSF82895; 23.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS01209; LDLRA_1; 8.
DR PROSITE; PS50068; LDLRA_2; 10.
DR PROSITE; PS50092; TSP1; 25.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 2.
DR PROSITE; PS51233; VWFD; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Disulfide bond;
KW EGF-like domain; Glycoprotein; Reference proteome; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..5150
FT /note="SCO-spondin"
FT /id="PRO_5000223757"
FT DOMAIN 18..102
FT /note="EMI"
FT DOMAIN 193..362
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 470..525
FT /note="TIL 1"
FT /evidence="ECO:0000255"
FT DOMAIN 563..736
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 828..881
FT /note="TIL 2"
FT /evidence="ECO:0000255"
FT DOMAIN 881..940
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 924..975
FT /note="TIL 3"
FT /evidence="ECO:0000255"
FT DOMAIN 1013..1183
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 1276..1332
FT /note="TIL 4"
FT /evidence="ECO:0000255"
FT DOMAIN 1376..1413
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1416..1451
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1452..1488
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1492..1530
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1565..1601
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1603..1642
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1656..1694
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1695..1749
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1751..1809
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1825..1864
FT /note="EGF-like 1"
FT DOMAIN 1865..1902
FT /note="EGF-like 2"
FT DOMAIN 1910..1966
FT /note="TSP type-1 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1966..2026
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 2066..2225
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DOMAIN 2234..2270
FT /note="LDL-receptor class A 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2391..2427
FT /note="LDL-receptor class A 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2464..2500
FT /note="LDL-receptor class A 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2501..2554
FT /note="TSP type-1 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2556..2611
FT /note="TSP type-1 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2633..2676
FT /note="TIL 5"
FT /evidence="ECO:0000255"
FT DOMAIN 2716..2770
FT /note="TSP type-1 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2773..2829
FT /note="TSP type-1 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2831..2884
FT /note="TSP type-1 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2986..3041
FT /note="TSP type-1 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3042..3084
FT /note="TSP type-1 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3091..3143
FT /note="TIL 6"
FT /evidence="ECO:0000255"
FT DOMAIN 3184..3251
FT /note="TSP type-1 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3253..3308
FT /note="TSP type-1 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3316..3366
FT /note="TIL 7"
FT /evidence="ECO:0000255"
FT DOMAIN 3409..3471
FT /note="TSP type-1 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3473..3528
FT /note="TSP type-1 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3530..3586
FT /note="TIL 8"
FT /evidence="ECO:0000255"
FT DOMAIN 3646..3694
FT /note="TSP type-1 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3812..3868
FT /note="TSP type-1 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3882..3934
FT /note="TSP type-1 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3948..4004
FT /note="TSP type-1 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4006..4061
FT /note="TSP type-1 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4064..4119
FT /note="TIL 9"
FT /evidence="ECO:0000255"
FT DOMAIN 4161..4214
FT /note="TSP type-1 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4255..4307
FT /note="TSP type-1 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4309..4365
FT /note="TSP type-1 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4367..4421
FT /note="TSP type-1 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4425..4480
FT /note="TIL 10"
FT /evidence="ECO:0000255"
FT DOMAIN 4617..4667
FT /note="TSP type-1 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4678..4726
FT /note="TIL 11"
FT /evidence="ECO:0000255"
FT DOMAIN 4766..4819
FT /note="TSP type-1 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4821..4875
FT /note="TIL 12"
FT /evidence="ECO:0000255"
FT DOMAIN 4987..5045
FT /note="VWFC 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 5044..5143
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 1529..1561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2306..2338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3499..3520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1544
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1545..1559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2312..2326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 515
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 820
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 912
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 945
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 987
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1353
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1651
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1664
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1810
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1994
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2031
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2646
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2695
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2937
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2968
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3063
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3311
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3513
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3523
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3600
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3627
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3793
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3916
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3948
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4348
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4419
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4734
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4751
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4756
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4866
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4906
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4951
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4958
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5064
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 195..323
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 217..361
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 239..245
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 565..698
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 589..735
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1015..1147
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1037..1182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1058..1065
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1377..1390
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1384..1403
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1397..1412
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1417..1429
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1424..1442
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1436..1453
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1453..1465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1460..1478
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1472..1487
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1493..1505
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1500..1518
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1512..1529
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1566..1578
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1573..1591
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1585..1600
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1604..1617
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1611..1630
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1624..1641
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1657..1667
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1662..1680
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1674..1695
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1707..1743
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1711..1748
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1722..1733
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1763..1803
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1767..1808
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1777..1787
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1911..1950
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1922..1926
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1960..1965
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2066..2225
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DISULFID 2235..2247
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2242..2260
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2254..2269
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2392..2404
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2399..2417
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2411..2426
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2465..2477
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2472..2490
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2484..2499
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2502..2538
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2513..2517
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2548..2553
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2568..2605
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2572..2610
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2583..2595
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2717..2755
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2728..2732
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2765..2769
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2785..2823
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2789..2828
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2805..2813
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2843..2878
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2847..2883
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2858..2868
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2987..3025
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2998..3002
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3035..3040
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3196..3245
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3200..3250
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3211..3235
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3265..3302
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3269..3307
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3280..3292
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3421..3464
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3425..3470
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3436..3448
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3485..3520
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3488..3527
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3498..3510
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3658..3688
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3662..3693
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3673..3678
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3824..3862
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3828..3867
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3840..3852
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3949..3985
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3960..3964
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3998..4003
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4018..4055
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4022..4060
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4033..4045
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4162..4198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4173..4177
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4208..4213
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4368..4405
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4379..4381
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4415..4420
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4778..4813
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4782..4818
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4793..4802
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 5044..5104
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5070..5121
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5080..5137
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5084..5139
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT VAR_SEQ 1..1123
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035258"
FT VAR_SEQ 1124..1127
FT /note="LWDG -> MLPP (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035259"
FT VAR_SEQ 1640
FT /note="A -> ACVEAPAPPAMRGPPGQAGGPTSSRAPSPPSPPEAQGEGRKGQERSR
FT THLTVPAGSTQLPLCPGLFPCGVAPGLCLTPEQLCDGIPDCPQGEDELD (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035260"
FT VAR_SEQ 1672
FT /note="L -> LVRVGVGGGGGSAMLPPSTRALTPLPPQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035261"
FT VAR_SEQ 2180..2315
FT /note="LFPRNWDDLDPAVWTFGRMVQARFVRVWPHDVHHSDVPLQVELLGCEPGSPP
FT APLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFHSTAKTLALSS
FT AQPGQLLHWPREGLAETEHWPPGQE -> VSPAQGRWGQQPTMPFCGFHSLCPQGPSSV
FT PEGHGLHSMLVEYLVSSRDCALWSRGLGATVTWMLETIQVAQTQGRYVKPARERGWGDT
FT KFTEGLREPRPTHVFVESSLGTALPSGGLHPSRRQTARSGRNQSVLC (in isoform
FT 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035262"
FT VAR_SEQ 2316..5147
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035263"
FT VARIANT 146
FT /note="Q -> R (in dbSNP:rs709061)"
FT /id="VAR_052660"
FT VARIANT 298
FT /note="V -> M (in dbSNP:rs17754559)"
FT /id="VAR_052661"
FT VARIANT 540
FT /note="V -> M (in dbSNP:rs855677)"
FT /id="VAR_059863"
FT VARIANT 1002
FT /note="R -> W (found in patient with Joubert syndrome;
FT unknown pathological significance; dbSNP:rs199648588)"
FT /evidence="ECO:0000269|PubMed:26477546"
FT /id="VAR_075709"
FT VARIANT 1273
FT /note="S -> P (in dbSNP:rs709060)"
FT /id="VAR_059864"
FT VARIANT 1274
FT /note="L -> P (in dbSNP:rs709060)"
FT /id="VAR_052662"
FT VARIANT 1425
FT /note="S -> G (in dbSNP:rs855691)"
FT /id="VAR_059865"
FT VARIANT 1449
FT /note="P -> Q (in dbSNP:rs855692)"
FT /id="VAR_059866"
FT VARIANT 1454
FT /note="P -> R (in dbSNP:rs2074704)"
FT /id="VAR_059867"
FT VARIANT 1779
FT /note="S -> P (in dbSNP:rs893601)"
FT /id="VAR_059868"
FT VARIANT 1794
FT /note="L -> P (in dbSNP:rs1635802)"
FT /id="VAR_059869"
FT VARIANT 1883
FT /note="R -> C (in dbSNP:rs1076277)"
FT /id="VAR_059870"
FT VARIANT 2018
FT /note="T -> M (in dbSNP:rs4725314)"
FT /id="VAR_059871"
FT VARIANT 2453
FT /note="M -> T (in dbSNP:rs2074689)"
FT /id="VAR_061915"
FT VARIANT 2542
FT /note="R -> Q (in dbSNP:rs59522380)"
FT /id="VAR_061916"
FT VARIANT 2799
FT /note="R -> C (found in patient with Joubert syndrome;
FT unknown pathological significance; dbSNP:rs181269877)"
FT /evidence="ECO:0000269|PubMed:26477546"
FT /id="VAR_075710"
FT VARIANT 2892
FT /note="L -> V (in dbSNP:rs10260959)"
FT /id="VAR_059872"
FT VARIANT 3274
FT /note="R -> W (in dbSNP:rs740109)"
FT /id="VAR_059873"
FT VARIANT 3513
FT /note="N -> S (in dbSNP:rs10952230)"
FT /id="VAR_059874"
FT VARIANT 3894
FT /note="C -> W (in dbSNP:rs1557955)"
FT /id="VAR_059875"
FT VARIANT 3911
FT /note="R -> C (in dbSNP:rs745044)"
FT /id="VAR_059876"
FT VARIANT 4030
FT /note="S -> I (in dbSNP:rs1005603)"
FT /id="VAR_059877"
FT VARIANT 4109
FT /note="Q -> H (in dbSNP:rs12536873)"
FT /id="VAR_061917"
FT VARIANT 4166
FT /note="H -> R (in dbSNP:rs10233245)"
FT /id="VAR_059878"
FT VARIANT 4332
FT /note="R -> C (in dbSNP:rs1008336)"
FT /id="VAR_059879"
FT VARIANT 4790
FT /note="H -> R (in dbSNP:rs1004200)"
FT /id="VAR_059880"
FT VARIANT 4944
FT /note="E -> K (in dbSNP:rs12534509)"
FT /id="VAR_059881"
SQ SEQUENCE 5150 AA; 547841 MW; 14C531CC9A29423E CRC64;
MLLPALLFGM AWALADGRWC EWTETIRVEE EVAPRQEDLV PCASLDHYSR LGWRLDLPWS
GRSGLTRSPA PGLCPIYKPP ETRPAKWNRT VRTCCPGWGG AHCTEALAKA SPEGHCFAMW
QCQLQAGSAN ASAGSLEECC ARPWGQSWWD GSSQACRSCS SRHLPGSASS PALLQPLAGA
VGQLWSQHQR PSATCASWSG FHYRTFDGRH YHFLGRCTYL LAGAADSTWA VHLTPGDRCP
QPGHCQRVTM GPEEVLIQAG NVSVKGQLVP EGQSWLLHGL SLQWLGDWLV LSGGLGVVVR
LDRTGSISIS VDHELWGQTQ GLCGLYNGWP EDDFMEPGGG LAMLAATFGN SWRLPGSESG
CLDAVEVAQG CDSPLGLIDA DVEPGHLRAE AQDVCHQLLE GPFGQCHAQV SPAEYHEACL
FAYCAGAMAG SGQEGRQQAV CATFASYVQA CARRHIHIRW RKPGFCERLC PGGQLYSDCV
SLCPPSCEAV GQGEEESCRE ECVSGCECPR GLFWNGTLCV PAAHCPCYYC RQRYVPGDTV
RQLCNPCVCR DGRWHCAQAL CPAECAVGGD GHYLTFDGRS YSFWGGQGCR YSLVQDYVKG
QLLILLEHGA CDAGSCLHAI SVSLEDTHIQ LRDSGAVLVN GQDVGLPWIG AEGLSVRRAS
SAFLLLRWPG AQVLWGLSDP VAYITLDPRH AHQVQGLCGT FTQNQQDDFL TPAGDVETSI
AAFASKFQVA GKGRCPSEDS ALLSPCTTHS QRHAFAEAAC AILHSSVFQE CHRLVDKEPF
YLRCLAAVCG CDPGSDCLCP VLSAYARRCA QEGASPPWRN QTLCPVMCPG GQEYRECAPA
CGQHCGKPED CGELGSCVAG CNCPLGLLWD PEGQCVPPSL CPCQLGARRY APGSATMKEC
NRCICQERGL WNCTARHCPS QAFCPRELVY APGACLLTCD SPSANHSCPA GSTDGCVCPP
GTVLLDERCV PPDLCPCRHS GQWYLPNATI QEDCNVCVCR GRQWHCTGQR RSGRCQASGA
PHYVTFDGLA FTYPGACEYL LVREASGLFT VSAQNLPCGA SGLTCTKALA VRLEGTVVHM
LRGRAVTVNG VSVTPPKVYT GPGLSLRRAG LFLLLSTHLG LTLLWDGGTR VLVQLSPQFR
GRVAGLCGDF DGDASNDLRS RQGVLEPTAE LAAHSWRLSP LCPEPGDLPH PCTMNTHRAG
WARARCGALL QPLFTLCHAE VPPQQHYEWC LYDACGCDSG GDCECLCSAI ATYADECARH
GHHVRWRSQE LCSLQCEGGQ VYEACGPTCP PTCHEQHPEP GWHCQVVACV EGCFCPEGTL
LHGGACLEPA SCPCEWGRNS FPPGSVLQKD CGNCTCQEGQ WHCGGDGGHC EELVPACAEG
EALCQENGHC VPHGWLCDNQ DDCGDGSDEE GCAAPGCGEG QMTCSSGHCL PLALLCDRQD
DCGDGTDEPS YPCPQGLLAC ADGRCLPPAL LCDGHPDCLD AADEESCLGQ VTCVPGEVSC
VDGTCLGAIQ LCDGVWDCPD GADEGPGHCP LPSLPTPPAS TLPGPSPGSL DTASSPLASA
SPAPPCGPFE FRCGSGECTP RGWRCDQEED CADGSDERGC GGPCAPHHAP CARGPHCVSP
EQLCDGVRQC PDGSDEGPDA CGGLPALGGP NRTGLPCPEY TCPNGTCIGF QLVCDGQPDC
GRPGQVGPSP EEQGCGAWGP WSPWGPCSRT CGPWGQGRSR RCSPLGLLVL QNCPGPEHQS
QACFTAACPV DGEWSTWSPW SVCSEPCRGT MTRQRQCHSP QNGGRTCAAL PGGLHSTRQT
KPCPQDGCPN ATCSGELMFQ PCAPCPLTCD DISGQVTCPP DWPCGSPGCW CPEGQVLGSE
GWCVWPRQCP CLVDGARYWP GQRIKADCQL CICQDGRPRR CRLNPDCAVD CGWSSWSPWA
KCLGPCGSQS IQWSFRSSNN PRPSGRGRQC RGIHRKARRC QTEPCEGCEH QGQVHRVGER
WHGGPCRVCQ CLHNLTAHCS PYCPLGSCPQ GWVLVEGTGE SCCHCALPGE NQTVQPMATP
AAAPAPSPQI RFPLATYILP PSGDPCYSPL GLAGLAEGSL HASSQQLEHP TQAALLGAPT
QGPSPQGWHA GGDAYAKWHT RPHYLQLDLL QPRNLTGILV PETGSSNAYA SSFSLQFSSN
GLHWHDYRDL LPGILPLPKL FPRNWDDLDP AVWTFGRMVQ ARFVRVWPHD VHHSDVPLQV
ELLGCEPGSP PAPLCPGVGL RCASGECVLR GGPCDGVLDC EDGSDEEGCV LLPEGTGRFH
STAKTLALSS AQPGQLLHWP REGLAETEHW PPGQESPTSP TETRPVSPGP ASGVPHHGES
VQMVTTTPIP QMEARTLPPG MAAVTVVPPH PVTPATPAGQ SVAPGPFPPV QCGPGQTPCE
VLGCVEQAQV CDGREDCLDG SDERHCARNL LMWLPSLPAL WAASTVPFMM PTMALPGLPA
SRALCSPSQL SCGSGECLSA ERRCDLRPDC QDGSDEDGCV DCVLAPWSVW SSCSRSCGLG
LTFQRQELLR PPLPGGSCPR DRFRSQSCFV QACPVAGAWA MWEAWGPCSV SCGGGHQSRQ
RSCVDPPPKN GGAPCPGASQ ERAPCGLQPC SGGTDCELGR VYVSADLCQK GLVPPCPPSC
LDPKANRSCS GHCVEGCRCP PGLLLHDTRC LPLSECPCLV GEELKWPGVS FLLGNCSQCV
CEKGELLCQP GGCPLPCGWS AWSSWAPCDR SCGSGVRARF RSPSNPPAAW GGAPCEGDRQ
ELQGCHTVCG TEVFGWTPWT SWSSCSQSCL APGGGPGWRS RSRLCPSPGD SSCPGDATQE
EPCSPPVCPV PSIWGLWAPW STCSAPCDGG IQTRGRSCSS LAPGDTTCPG PHSQTRDCNT
QPCTAQCPEN MLFRSAEQCH QEGGPCPRLC LTQGPGIECT GFCAPGCTCP PGLFLHNASC
LPRSQCPCQL HGQLYASGAM ARLDSCNNCT CVSGKMACTS ERCPVACGWS PWTLWSLCSC
SCNVGIRRRF RAGTAPPAAF GGAECQGPTM EAEFCSLRPC PGPGGEWGPW SPCSVPCGGG
YRNRTRGSSR SLMEFSTCGL QPCAGPVPGM CPRDKQWLDC AQGPASCAEL SAPRGTNQTC
HPGCHCPSGM LLLNNVCVPT QDCPCAHEGH LYPPGSTVVR PCENCSCVSG LIANCSSWPC
AEGEPTWSPW TPWSQCSASC GPARCHRHRF CARSPSAVPS TVAPLPLPAT PTPLCSGPEA
EEEPCLLQGC DRAGGWGPWG PWSHCSRSCG GGLRSRTRAC DQPPPQGLGD YCEGPRAQGE
VCQALPCPVT NCTAIEGAEY SPCGPPCPRS CDDLVHCVWR CQPGCYCPPG QVLSSNGAIC
VQPGHCSCLD LLTGQRHHPG ARLARPDGCN HCTCLEGRLN CTDLPCPVPG GWCPWSEWTM
CSQPCRGQTR SRSRACACPT PQHGGAPCTG EAGEAGAQHQ REACPSYATC PVDGAWGPWG
PWSPCDMCLG QSHRSRACSR PPTPEGGRPC PGNHTQSRPC QENSTQCTDC GGGQSLHPCG
QPCPRSCQDL SPGSVCQPGS VGCQPTCGCP LGQLSQDGLC VPPAHCRCQY QPGAMGIPEN
QSRSAGSRFS SWESLEPGEV VTGPCDNCTC VAGILQCQEV PDCPDPGVWS SWGPWEDCSV
SCGGGEQLRS RRCARPPCPG PARQSRTCST QVCREAGCPA GRLYRECQPG EGCPFSCAHV
TQQVGCFSEG CEEGCHCPEG TFQHRLACVQ ECPCVLTAWL LQELGATIGD PGQPLGPGDE
LDSGQTLRTS CGNCSCAHGK LSCSLDDCFE ADGGFGPWSP WGPCSRSCGG LGTRTRSRQC
VLTMPTLSGQ GCRGPRQDLE YCPSPDCPGA EGSTVEPVTG LPGGWGPWSS WSPCSRSCTD
PARPAWRSRT RLCLANCTMG DPLQERPCNL PSCTELPVCP GPGCGAGNCS WTSWAPWEPC
SRSCGVGQQR RLRAYRPPGP GGHWCPNILT AYQERRFCNL RACPVPGGWS RWSPWSWCDR
SCGGGQSLRS RSCSSPPSKN GGAPCAGERH QARLCNPMPC EAGCPAGMEV VTCANRCPRR
CSDLQEGIVC QDDQVCQKGC RCPKGSLEQD GGCVPIGHCD CTDAQGHSWA PGSQHQDACN
NCSCQAGQLS CTAQPCPPPT HCAWSHWSAW SPCSHSCGPR GQQSRFRSST SGSWAPECRE
EQSQSQPCPQ PSCPPLCLQG TRSRTLGDSW LQGECQRCSC TPEGVICEDT ECAVPEAWTL
WSSWSDCPVS CGGGNQVRTR ACRAAAPHHR SPPCLGPDTQ TRQQPCPGLL EACSWGPWGP
CSRSCGPGLA SRSGSCPCLM AKADPTCNST FLHLDTQGCY SGPCPEECVW SSWSSWTRCS
CRVLVQQRYR HQGPASRGAR AGAPCTRLDG HFRPCLISNC SEDSCTPPFE FHACGSPCAG
LCATHLSHQL CQDLPPCQPG CYCPKGLLEQ AGGCIPPEEC NCWHTSAAGA GMTLAPGDRL
QLGCKECECR RGELHCTSQG CQGLLPLSEW SEWSPCGPCL PPSALAPASR TALEEHWLRD
PTGLSPTLAP LLASEQHRHR LCLDPATGRP WTGAPHLCTA PLSQQRLCPD PGACPDSCQW
SLWGPWSPCQ VPCSGGFRLR WREAEALCGG GCREPWAQES CNGGPCPESC EAQDTVFTLD
CANQCPHSCA DLWDRVQCLQ GPCRPGCRCP PGQLVQDGRC VPISSCRCGL PSANASWELA
PAQAVQLDCQ NCTCVNESLV CPHQECPVLG PWSAWSSCSA PCGGGTMERH RTCEGGPGVA
PCQAQDTEQR QECNLQPCPE CPPGQVLSAC ATSCPCLCWH LQPGAICVQE PCQPGCGCPG
GQLLHNGTCV PPTACPCTQH SLPWGLTLTL EEQAQELPPG TVLTRNCTRC VCHGGAFSCS
LVDCQVPPGE TWQQVAPGEL GLCEQTCLEM NATKTQSNCS SARASGCVCQ PGHFRSQAGP
CVPEDHCECW HLGRPHLPGS EWQEACESCL CLSGRPVCTQ HCSPLTCAQG EEMVLEPGSC
CPSCRREAPE EQSPSCQLLT ELRNFTKGTC YLDQVEVSYC SGYCPSSTHV MPEEPYLQSQ
CDCCSYRLDP ESPVRILNLR CLGGHTEPVV LPVIHSCQCS SCQGGDFSKR
