SSPO_MOUSE
ID SSPO_MOUSE Reviewed; 4998 AA.
AC Q8CG65; E9QMN0;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=SCO-spondin;
DE Flags: Precursor;
GN Name=Sspo {ECO:0000312|MGI:MGI:2674311};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=ICR; TISSUE=Brain;
RX PubMed=12909363; DOI=10.1016/s0378-1119(03)00622-x;
RA Goncalves-Mendes N., Simon-Chazottes D., Creveaux I., Meiniel A.,
RA Guenet J.-L., Meiniel R.;
RT "Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR)
RT superfamily expressed in the brain.";
RL Gene 312:263-270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Involved in the modulation of neuronal aggregation (By
CC similarity). May be involved in developmental events during the
CC formation of the central nervous system (By similarity).
CC {ECO:0000250|UniProtKB:P98167}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:P98167}.
CC -!- TISSUE SPECIFICITY: Subcommissural organ.
CC {ECO:0000269|PubMed:12909363}.
CC -!- DEVELOPMENTAL STAGE: Weakly expressed at 14 dpc and 15 dpc in the SCO
CC anlage; increasing progressively until 17 dpc.
CC {ECO:0000269|PubMed:12909363}.
CC -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
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DR EMBL; AJ491857; CAD42654.1; -; mRNA.
DR EMBL; AC153815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; Q8CG65; -.
DR STRING; 10090.ENSMUSP00000131401; -.
DR GlyGen; Q8CG65; 43 sites.
DR iPTMnet; Q8CG65; -.
DR PhosphoSitePlus; Q8CG65; -.
DR PaxDb; Q8CG65; -.
DR PRIDE; Q8CG65; -.
DR ProteomicsDB; 257476; -.
DR Ensembl; ENSMUST00000043676; ENSMUSP00000047991; ENSMUSG00000029797.
DR UCSC; uc009bul.1; mouse.
DR MGI; MGI:2674311; Sspo.
DR VEuPathDB; HostDB:ENSMUSG00000029797; -.
DR eggNOG; KOG1215; Eukaryota.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG3509; Eukaryota.
DR eggNOG; KOG3538; Eukaryota.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000155829; -.
DR InParanoid; Q8CG65; -.
DR Reactome; R-MMU-5173214; O-glycosylation of TSR domain-containing proteins.
DR ChiTaRS; Sspo; mouse.
DR PRO; PR:Q8CG65; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8CG65; protein.
DR Bgee; ENSMUSG00000029797; Expressed in hypothalamus and 42 other tissues.
DR ExpressionAtlas; Q8CG65; baseline and differential.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR CDD; cd00112; LDLa; 8.
DR Gene3D; 2.20.100.10; -; 23.
DR Gene3D; 4.10.400.10; -; 8.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR030119; SCO-spondin.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF358; PTHR11339:SF358; 6.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF01826; TIL; 13.
DR Pfam; PF00090; TSP_1; 23.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00832; C8; 3.
DR SMART; SM00192; LDLa; 10.
DR SMART; SM00209; TSP1; 25.
DR SMART; SM00214; VWC; 4.
DR SMART; SM00215; VWC_out; 9.
DR SMART; SM00216; VWD; 2.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF57424; SSF57424; 9.
DR SUPFAM; SSF57567; SSF57567; 14.
DR SUPFAM; SSF82895; SSF82895; 24.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS01209; LDLRA_1; 8.
DR PROSITE; PS50068; LDLRA_2; 10.
DR PROSITE; PS50092; TSP1; 25.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 2.
DR PROSITE; PS51233; VWFD; 3.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..4998
FT /note="SCO-spondin"
FT /id="PRO_0000245043"
FT DOMAIN 18..102
FT /note="EMI"
FT DOMAIN 72..241
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 349..404
FT /note="TIL 1"
FT /evidence="ECO:0000255"
FT DOMAIN 404..496
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 442..615
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 706..759
FT /note="TIL 2"
FT /evidence="ECO:0000255"
FT DOMAIN 892..1062
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 1153..1209
FT /note="TIL 3"
FT /evidence="ECO:0000255"
FT DOMAIN 1253..1290
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1293..1328
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1329..1365
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1369..1407
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1442..1478
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1480..1519
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1533..1571
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1572..1626
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1628..1686
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1692..1746
FT /note="TIL 4"
FT /evidence="ECO:0000255"
FT DOMAIN 1702..1741
FT /note="EGF-like 1"
FT DOMAIN 1742..1768
FT /note="EGF-like 2"
FT DOMAIN 1771..1827
FT /note="TSP type-1 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1827..1887
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 1929..2085
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DOMAIN 2091..2127
FT /note="LDL-receptor class A 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2242..2278
FT /note="LDL-receptor class A 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2299..2335
FT /note="LDL-receptor class A 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2336..2389
FT /note="TSP type-1 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2391..2446
FT /note="TSP type-1 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2468..2511
FT /note="TIL 5"
FT /evidence="ECO:0000255"
FT DOMAIN 2551..2605
FT /note="TSP type-1 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2609..2664
FT /note="TSP type-1 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2666..2719
FT /note="TSP type-1 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2820..2875
FT /note="TSP type-1 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2876..2919
FT /note="TSP type-1 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2926..2978
FT /note="TIL 6"
FT /evidence="ECO:0000255"
FT DOMAIN 3019..3086
FT /note="TSP type-1 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3088..3143
FT /note="TSP type-1 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3151..3201
FT /note="TIL 7"
FT /evidence="ECO:0000255"
FT DOMAIN 3244..3306
FT /note="TSP type-1 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3308..3363
FT /note="TSP type-1 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3365..3421
FT /note="TIL 8"
FT /evidence="ECO:0000255"
FT DOMAIN 3481..3529
FT /note="TSP type-1 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3657..3713
FT /note="TSP type-1 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3727..3779
FT /note="TSP type-1 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3793..3849
FT /note="TSP type-1 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3851..3906
FT /note="TSP type-1 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3909..3964
FT /note="TIL 9"
FT /evidence="ECO:0000255"
FT DOMAIN 4006..4059
FT /note="TSP type-1 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4100..4155
FT /note="TSP type-1 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4157..4213
FT /note="TSP type-1 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4215..4269
FT /note="TSP type-1 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4273..4328
FT /note="TIL 10"
FT /evidence="ECO:0000255"
FT DOMAIN 4465..4516
FT /note="TSP type-1 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4530..4576
FT /note="TIL 11"
FT /evidence="ECO:0000255"
FT DOMAIN 4616..4669
FT /note="TSP type-1 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4671..4725
FT /note="TIL 12"
FT /evidence="ECO:0000255"
FT DOMAIN 4777..4835
FT /note="TIL 13"
FT /evidence="ECO:0000255"
FT DOMAIN 4835..4893
FT /note="VWFC 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 4892..4991
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 1406..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2119..2209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2127..2142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2186..2203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 534
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 698
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 771
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 790
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 824
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 866
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1230
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1598
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1687
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1892
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1989
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2481
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2530
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2772
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2802
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2897
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2952
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2999
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3009
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3357
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3435
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3462
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3638
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3761
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3986
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4196
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4408
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4463
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4584
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4601
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4606
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4716
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4756
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4799
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4806
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4912
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 74..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 103..240
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 444..577
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 468..614
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 894..1026
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 916..1061
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 937..944
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1254..1267
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1261..1280
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1274..1289
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1294..1306
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1301..1319
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1313..1328
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1330..1342
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1337..1355
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1349..1364
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1370..1382
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1377..1395
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1389..1406
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1443..1455
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1450..1468
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1462..1477
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1481..1494
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1488..1507
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1501..1518
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1534..1544
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1539..1557
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1551..1572
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1584..1620
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1588..1625
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1599..1610
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1640..1680
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1644..1685
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1654..1664
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1772..1811
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1783..1787
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1821..1826
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2092..2104
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2099..2117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2111..2126
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2243..2255
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2250..2268
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2262..2277
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2300..2312
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2307..2325
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2319..2334
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2337..2373
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2348..2352
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2383..2388
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2403..2440
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2407..2445
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2418..2430
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2552..2590
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2563..2567
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2600..2604
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2620..2658
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2624..2663
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2640..2648
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2678..2713
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2682..2718
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2693..2703
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2821..2859
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2832..2836
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2869..2874
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3031..3080
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3035..3085
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3046..3070
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3100..3137
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3104..3142
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3115..3127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3256..3299
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3260..3305
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3271..3283
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3320..3355
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3323..3362
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3333..3345
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3493..3523
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3497..3528
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3508..3513
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3669..3707
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3673..3712
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3685..3697
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3794..3830
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3805..3809
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3843..3848
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3863..3900
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3867..3905
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3878..3890
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4007..4043
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4018..4022
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4053..4058
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4112..4149
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4116..4154
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4127..4139
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4169..4207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4173..4212
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4184..4195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4216..4253
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4227..4229
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4263..4268
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4466..4500
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4477..4481
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4510..4515
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4628..4663
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4632..4668
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4643..4652
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4892..4952
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 4918..4969
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 4928..4985
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 4932..4987
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT CONFLICT 192
FT /note="H -> Q (in Ref. 1; CAD42654)"
FT /evidence="ECO:0000305"
FT CONFLICT 1043
FT /note="V -> L (in Ref. 1; CAD42654)"
FT /evidence="ECO:0000305"
FT CONFLICT 1049
FT /note="E -> Y (in Ref. 1; CAD42654)"
FT /evidence="ECO:0000305"
FT CONFLICT 1071
FT /note="V -> W (in Ref. 1; CAD42654)"
FT /evidence="ECO:0000305"
FT CONFLICT 1080
FT /note="R -> P (in Ref. 1; CAD42654)"
FT /evidence="ECO:0000305"
FT CONFLICT 1769
FT /note="F -> G (in Ref. 1; CAD42654)"
FT /evidence="ECO:0000305"
FT CONFLICT 3379
FT /note="P -> R (in Ref. 1; CAD42654)"
FT /evidence="ECO:0000305"
FT CONFLICT 3412
FT /note="D -> H (in Ref. 1; CAD42654)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 4998 AA; 534975 MW; 52726F62E3639AEC CRC64;
MLPLALLFGM LWTQANGHWC EQIETVHVEE EVTPRQEDLV PCTSLYHYSR LGWQLDLSWS
GRVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG AHCTDALAET SPKGHCFVTW
HCQPLAGSAN SSAGSLEDPA DELGVWPLTL NDPILFPGMS LQWQGDWLVL SGGLGVVVRL
DRSSSISISV DHEFWGRTQG LCGLYNGRPE DDFVEPGGGL ATLAATFGNS WKLPGSEPGC
LDAVEVAWGC ESLLGGTLTD LEAVKLQAQA QDMCHQLLEG PFWQCHGQVQ PDEYHETCLF
AYCVGATAGN GPEGQLEAVC ATFANYAQAC ARQHIYVHWR KPGFCERVCP GGQLYSDCVS
SCPPSCSAVA QGEEGSCGKE CVSGCECPTG LFWDGALCVP AAHCPCYHRR QRYAPGDTVK
QQCNPCVCQD GRWHCAQALC PAECAVGGDG HYFTFDGRSF FFRGTPGCHY SLVQDSVKGQ
LLVVLEHGAC DTGSCLHALS VFLGNTHIQL RYSGAVLVDG EDVDLPWIGV EGFNISWASS
TFLLLHWPGA WVLWGVAEPA AYITLDPRHA YQVQGLCGTF TWKQQDDFLT PAGDIETSVT
AFASKFQVSG DGRCPLVDKS PLFCSSYSQH LTFTEAACAI LHGHAFQECH GLVDREPFRL
RCLEAVCGCA PGRDCLCPVL SAYTRHCAQE GVLLQWRNET LCPVSCPGGQ VYQECAPVCG
HHCGEPEDCK ELGICVAGCN CPPGLLWDLE GQCVPPSMCH CQFGGHRYTI NTTTVRDCSH
CICQERGLWN CTAHHCPRQW ALCPRELIYV PGACLLTCDS PRANHSCWAG STDGCVCPPG
TVLLDKHCVS PDLCPCRHNG QWYPPNATIQ EDCNICVCQG QRWHCTGQRC SGWCQASGAP
HYVTFDGLVF TFPGACEYLL VREAGGRFSV SVQNLPCGAS GLTCTKALVV RLDSTVVHML
RGQAVTVNGV SIRLPKVYTG PGLSLHHAGL FLLLTTRLGL TLLWDGGTRV LVQLSPHFHG
RVAGLCGNFD SDASNDLRSR QGVLEPTAEL TAHSWRLNPL CPEPGDLPHP VNAHRANWAR
ARCEVILQPI FAPCHTEVPP QQYYEWCVYD ACGCDTGGDC ECLCSAIATY ADECARHRHH
VRWRSQELCP LQCEGGQVYE PCGSTCPPTC HDHHSELRWH CQVITCVEGC FCPEGTLLHG
GACMKLAACP CEWQGSFFPP GTVLQKDCGN CTCQGSQWHC DRGGAPCEDM EPGCAEGETL
CRENGHCVPL EWLCDNQDDC GDGSDEEGCA TSVCGEGQMS CQSGHCLPLS LICDGQDDCG
DGTDEQGCLC PHGSLACADG RCLPPALLCN GHPDCLDAAD EESCLGPVSC ISGEVSCVDG
TCVRTIQLCD GVWDCPDGAD EGPSHCSLPS LPTPPGGIGQ NPSTSSLDTA PSPVGSTSPA
SPCSLLEFQC NSGECTPRGW RCDQEEDCTD GSDELDCGGP CMLYQVPCAH SPHCVSPGQL
CDGVTQCPDG SDEDPDVCEE QSASGGANRT GAPCPEFSCP DGTCIDFLLV CDGNPDCELA
DETEPSLDEQ GCGAWGSWGP WAPCSQTCGS GTRSRNRNCS TSSLQVLQNC PGLQHQSQAC
FTEACPVDGE WSSWSPWSPC SEPCGGTTTR HRQCRPPQNG GQDCALLPGS THSTRQTSPC
PQEGCLNATC FGELVFRTCA PCPLTCDDIS GQAACPPDRP CSSPGCWCPD GKVLNTEGQC
VRPRQCPCLV DGAHYWPGQR IKMDCQLCFL DCGWSSWSPW AECLGPCSSQ SLQWSFRSPN
NPRLSGHGRQ CRGIHRKARR CQTEACEGCE QWGLMYNVGE RWRGGPCMVC ECLHSSITHC
SPYCPIGSCP QGWVLVEGMG ESCCHCALPE KNQTVIHMTT PAPAPASAPS PQIGAHLVTY
VLPPTADACY SPLGLAGLPM WAPSQHWEHI TRADPVEAPM AGPGPREGAS AEWHTQPLYL
QLDLRRPRNL TGIIVQRAGS SAAYVSTLSL QFSSDNLQWH NYVNSLSSTL SPPKPSPESS
NHMAPEVWTF DQMVQARYIR VWPHSGHLRD NNQHDIFLWV ELLGLSPLAP LCPGSRHRCA
SGECAPKGGP CDGAVDCDDG SDEEGCGSLH ASTTSRTPAL SPTQPGKFPR EVSEDLRQGA
EAMTSHSPPS SGETAGLIPA SEGTLPVSGQ PMQTLSATST FPPGAKSLHP GMAAVTVHPP
HSVTPGAPVG QTVSPRPFPP MPCGPGQVPC DVLGCVEQEQ LCDGREDCLD GSDEQHCASA
EPFTVPTTAL PGLPASKALC SPSQLRCGSG ECLPFEHRCD LQVNCQDGSD EDNCVDCVLA
PWSGWSDCSR SCGLGLIFQH RELLRLPLPG GSCLLDQFRS QSCFVQACPV AGAWAEWGPW
TACSVSCGGG HQSRQRSCVD PPPKNGGAPC PGPSHEKAPC NLQLCPGDTD CEPGLVHVNA
ELCQKGLVPP CPPSCLDPEA NRSCSGHCME GCRCPPGLLL QDSHCLPLSE CPCLVGQKLI
QPRLAFLLDN CSQCICEKGT LLCKPGACSQ SCGWSAWSPW TACDRSCGSG VRARFRSPTN
PPVAFGGSPC EGDRQELQAC YTDCGTEIPG WTPWTSWSSC SQSCLVPGGD PGWRQRSRLC
PSSRDTFCPG EATQEEPCSP PVCPVPSAWG LWASWSTCSA SCNGGIQTRG RSCSGSAPGN
PVCLGPHTQT RDCNMHPCTA QCPGNMVFRS AEQCLEEGGP CPQLCLAQDP GVECTGSCAP
SCNCPPGLFL HNASCLPRSQ CPCQLHGQLY APGAVAHLDC NNCTCISGEM VCTSKRCPVA
CGWSPWTPWS PCSQSCNVGI RRRFRAGTEP PAAFGGAECQ GPNLDAEFCS LRPCRGPGAA
WSSWTPCSVP CGGGYRNRTQ GSGPHSPIEF STCSLQPCAG PVPGVCPEDQ QWLDCAQGPA
SCAHLSIPGE ANQTCHPGCY CLSGMLLLNN VCVPVQDCPC AHRGRLYSPG SAVHLPCENC
SCISGLITNC SSWPCEEGQP AWSSWTPWSV CSASCNPARR HRHRFCARPP HRAPFSLVLL
TTVAAPTTLC PGPEAEEEPC LLPGCNQAGG WSPWSPWSGC SRSCGGGLRS RTRACDQPSP
QGLGDFCEGP QAQGEACQAQ PCPVTNCSAM EGAEYSPCGP PCPRSCDDLV HCVWRCQPGC
YCPLGKVLSA DGAICVKPSY CSCLDLLTGK RHHAGTQLMR PDGCNHCTCM EGRLNCTDLP
CQVSGDWCPW SKWTACSQPC RGQTRTRSRA CVCPAPQHGG SPCPEESGGT GVQHQMEACP
NATACPVDGA WSPWGPWSSC DACLGQSYRS RVCSHPPISD GGKPCLGGYQ QSRPCRNSST
LCTDCGGGQD LLPCGQPCPH SCQDLSLGST CQPGSAGCQS GCGCPPGQLS QDGLCVFPVD
CHCHFQPRAM GIPENRSRSV GSTLSSWESL EPGEVVTGPC DNCTCVAGIL QCHEVPSCPG
PGIWSSWGPW EKCSVSCGGG EQLRSRQCAR PPCPGLAQQS RICHIHVCRE TGCPAGRLYR
ECQPSDGCPF SCAHVTGQVA CFSERCKEGC HCPEGTFQHH VACVQECPCV LTVLLLQELG
LASAALGSYP TLLGDEGKPL GPGVELLPGQ MLQTDCGNCS CVHGKLSCSM VECSRVHGSF
GPWGMWSLCS RSCGGLGTRT RTRQCVLPTL APGGLSCRGP LQDLEYCFSP ECPGTAGSTV
EPVTGLAGGW GPWSPWSPCS HSCTDPAHPA WRSRTRLCLA NCTVGDSSQE RPCNLPSCAA
LLPCPGPGCG SGNCFWTSWA PWEPCSRSCG VGQQRRLRAY HPPGPGGHWC PDILTAYQER
RFCNLRACPV PGGWSHWSPW SWCDRSCGGG RSLRSRSCSS PPPKNGGTSC VGERHHVRPC
NPMPCEEGCP AGMEMVSCAN HCPYSCSDLQ EGGMCQEDQA CQLGCRCSEG FLEQDGGCVP
VGHCECTDAQ GRSWAPGSQH QDACNNCSCQ AGQLSCTAQL CSPPAHCAWS HWSAWSSCSH
SCGPQGQQSR FRSSTSGSWA LECQKEQSQS QPCPEVPCPP LCLHEAHLHE LGDNWLHGEC
QQCSCTPEGA ICKDTDCAVP RGWTLWSSWS YCSVSCGGGS QVRTRSCTVS APPHGSLSCE
GPDTQTRHCG QQLCLQKLER CSWGPWGPCS RSCGTGLASR SGSCPCLLTK EDSKCNDTFL
GLDTQACYSG PCQDDCTWGD WSSWTRCSCK VLVQQRYRHQ VPAPGQAGEG TPCTRLDGHF
RPCTIGNCSE DSCPPPFEFQ SCGSPCAGLC ATHLNHRLCQ DLPPCQPGCY CPKGLLEQAG
SCILPEQCNC WHISGEGARV TLAPGDRLQL GCKECVCRRG ELQCSSQGCE GLLPLTGWSE
WSPCGPCLPQ SALAPASRTA LEGHWPLNTS DLPPPSVTLL ASEQYRHRLC LDPETRRPWA
GDPALCTVPL SQQRLCPDPG ACNDTCQWGP WGPWSPCQMP CSGGFKLRWR VARDTSAGEC
PGPWAQTESC NMGSCPGESC ETRDTVFTLD CANQCPRSCA DLWDGVQCLQ GPCSPGCRCP
PGQLVQDGHC VPISSCRCGL PSANASWELA PTQVVQLDCH NCTCINGTLM CPHLECPVLG
PWSAWSECSA VCGKGTMVRH RSCEEHPDRE PCQALDLQQW QECNLQACPE CPPGQVLSTC
ATMCPSLCSH LWPGTICVRE PCQLGCGCPG GQLLYNGTCI PPEACPCTQF SLPWGLTLPL
EEQARELPSG TVLTRNCTHC TCQGGAFICS LTDCQECAPG EIWQHGKLGP CEKTCPEMNM
TQAWSNCTEA QAPGCVCQLG YFRSQTGLCV PEDHCECWHH GSPHLPGSEW QEACESCRCL
HGKSVCIRHC PELSCAQGEV IMQEPGSCCP ICQQDTLKEE PVSCRYLTEL RNLTKGPCHL
DQIEVSYCSG HCRSSTNVMT EEPYLQSQCD CCSYRLDPDS PVRILNLLCP DGHTEPVVLP
VIHSCQCSAC QGGDFSKH
