ID   ABHEA_RAT               Reviewed;         242 AA.
AC   Q5I0C4;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Protein ABHD14A {ECO:0000305};
DE            EC=3.-.-.-;
DE   AltName: Full=Alpha/beta hydrolase domain-containing protein 14A {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 14A {ECO:0000312|RGD:1309721};
GN   Name=Abhd14a {ECO:0000312|RGD:1309721};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Possible role in granule neuron development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305};
CC       Single-pass type II membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD14 family.
CC       {ECO:0000305}.
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DR   EMBL; BC088472; AAH88472.1; -; mRNA.
DR   RefSeq; NP_001009670.1; NM_001009670.1.
DR   RefSeq; XP_006243779.1; XM_006243717.3.
DR   RefSeq; XP_006243782.1; XM_006243720.3.
DR   RefSeq; XP_008764716.1; XM_008766494.2.
DR   RefSeq; XP_008764717.1; XM_008766495.2.
DR   RefSeq; XP_008764718.1; XM_008766496.2.
DR   RefSeq; XP_008764720.1; XM_008766498.2.
DR   AlphaFoldDB; Q5I0C4; -.
DR   SMR; Q5I0C4; -.
DR   STRING; 10116.ENSRNOP00000016056; -.
DR   ESTHER; rat-abhea; CIB-CCG1-interacting-factor-B.
DR   MEROPS; S33.981; -.
DR   GlyGen; Q5I0C4; 1 site.
DR   PaxDb; Q5I0C4; -.
DR   GeneID; 300982; -.
DR   KEGG; rno:300982; -.
DR   UCSC; RGD:1309721; rat.
DR   CTD; 25864; -.
DR   RGD; 1309721; Abhd14a.
DR   VEuPathDB; HostDB:ENSRNOG00000011936; -.
DR   eggNOG; ENOG502QR0B; Eukaryota.
DR   InParanoid; Q5I0C4; -.
DR   OMA; GWSFNAD; -.
DR   OrthoDB; 616687at2759; -.
DR   PhylomeDB; Q5I0C4; -.
DR   PRO; PR:Q5I0C4; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000011936; Expressed in kidney and 19 other tissues.
DR   ExpressionAtlas; Q5I0C4; baseline and differential.
DR   Genevisible; Q5I0C4; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   Pfam; PF12697; Abhydrolase_6; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Glycoprotein; Hydrolase; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..242
FT                   /note="Protein ABHD14A"
FT                   /id="PRO_0000282287"
FT   TRANSMEM        6..26
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        142
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        193
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        220
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   242 AA;  26761 MW;  F1AF6D8519EA7041 CRC64;
     MSRYQAALLG LGLLLMFLLY MGLPGPPKQT SQLGRGPNVT VLTGLTRGSS QIFYREVLPL
     QQTHRAEVVF LHGKAFNSHT WEQLGTLQLL SKRGYRAVAV DLPGFGNSAP SKEVSTESGR
     VELLEGVLRD LQLQNTVLVS PSLSGSYALP FLMQSHHQLC GFVPIAPTST RNYAQEQFQA
     VKTPTLILYG ELDHTLARES LQQLRHLPNH SVVKLHNAGH ACYLHKPEAF HLALLAFLDH
     LP