SSR1_HUMAN
ID SSR1_HUMAN Reviewed; 391 AA.
AC P30872;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Somatostatin receptor type 1;
DE Short=SS-1-R;
DE Short=SS1-R;
DE Short=SS1R;
DE Short=SST1;
DE AltName: Full=SRIF-2;
GN Name=SSTR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1346068; DOI=10.1073/pnas.89.1.251;
RA Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.;
RT "Cloning and functional characterization of a family of human and mouse
RT somatostatin receptors expressed in brain, gastrointestinal tract, and
RT kidney.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH SKB1.
RX PubMed=10734105; DOI=10.1074/jbc.275.13.9557;
RA Schwaerzler A., Kreienkamp H.-J., Richter D.;
RT "Interaction of the somatostatin receptor subtype 1 with the human homolog
RT of the Shk1 kinase-binding protein from yeast.";
RL J. Biol. Chem. 275:9557-9562(2000).
CC -!- FUNCTION: Receptor for somatostatin with higher affinity for
CC somatostatin-14 than -28. This receptor is coupled via pertussis toxin
CC sensitive G proteins to inhibition of adenylyl cyclase. In addition it
CC stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via
CC pertussis toxin insensitive G proteins.
CC -!- SUBUNIT: Interacts with SKB1. {ECO:0000269|PubMed:10734105}.
CC -!- INTERACTION:
CC P30872; P35346: SSTR5; NbExp=3; IntAct=EBI-21273948, EBI-27053622;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Fetal kidney, fetal liver, and adult pancreas,
CC brain, lung, jejunum and stomach.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; M81829; AAA58247.1; -; Genomic_DNA.
DR EMBL; AY322536; AAP84349.1; -; Genomic_DNA.
DR EMBL; BC035618; AAH35618.1; -; mRNA.
DR CCDS; CCDS9666.1; -.
DR PIR; A41795; A41795.
DR RefSeq; NP_001040.1; NM_001049.2.
DR AlphaFoldDB; P30872; -.
DR SMR; P30872; -.
DR BioGRID; 112629; 17.
DR CORUM; P30872; -.
DR IntAct; P30872; 2.
DR STRING; 9606.ENSP00000267377; -.
DR BindingDB; P30872; -.
DR ChEMBL; CHEMBL1917; -.
DR DrugBank; DB15494; Edotreotide gallium Ga-68.
DR DrugBank; DB13985; Lutetium Lu 177 dotatate.
DR DrugBank; DB06663; Pasireotide.
DR DrugBank; DB09099; Somatostatin.
DR DrugCentral; P30872; -.
DR GuidetoPHARMACOLOGY; 355; -.
DR GlyGen; P30872; 3 sites.
DR iPTMnet; P30872; -.
DR PhosphoSitePlus; P30872; -.
DR BioMuta; SSTR1; -.
DR DMDM; 401124; -.
DR MassIVE; P30872; -.
DR PaxDb; P30872; -.
DR PeptideAtlas; P30872; -.
DR PRIDE; P30872; -.
DR Antibodypedia; 4061; 433 antibodies from 39 providers.
DR DNASU; 6751; -.
DR Ensembl; ENST00000267377.3; ENSP00000267377.2; ENSG00000139874.6.
DR GeneID; 6751; -.
DR KEGG; hsa:6751; -.
DR MANE-Select; ENST00000267377.3; ENSP00000267377.2; NM_001049.3; NP_001040.1.
DR UCSC; uc001wul.2; human.
DR CTD; 6751; -.
DR DisGeNET; 6751; -.
DR GeneCards; SSTR1; -.
DR HGNC; HGNC:11330; SSTR1.
DR HPA; ENSG00000139874; Tissue enhanced (brain, intestine, stomach).
DR MIM; 182451; gene.
DR neXtProt; NX_P30872; -.
DR OpenTargets; ENSG00000139874; -.
DR PharmGKB; PA36154; -.
DR VEuPathDB; HostDB:ENSG00000139874; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161442; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; P30872; -.
DR OMA; PDNMESD; -.
DR OrthoDB; 993446at2759; -.
DR PhylomeDB; P30872; -.
DR TreeFam; TF315737; -.
DR PathwayCommons; P30872; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; P30872; -.
DR SIGNOR; P30872; -.
DR BioGRID-ORCS; 6751; 7 hits in 1071 CRISPR screens.
DR GeneWiki; Somatostatin_receptor_1; -.
DR GenomeRNAi; 6751; -.
DR Pharos; P30872; Tclin.
DR PRO; PR:P30872; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; P30872; protein.
DR Bgee; ENSG00000139874; Expressed in stromal cell of endometrium and 111 other tissues.
DR Genevisible; P30872; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0004994; F:somatostatin receptor activity; IDA:MGI.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
DR GO; GO:0007215; P:glutamate receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; TAS:ProtInc.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0042594; P:response to starvation; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000586; Somatstn_rcpt.
DR InterPro; IPR001116; Somatstn_rcpt_1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00246; SOMATOSTATNR.
DR PRINTS; PR00587; SOMATOSTTN1R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..391
FT /note="Somatostatin receptor type 1"
FT /id="PRO_0000070116"
FT TOPO_DOM 1..56
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..84
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..120
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..131
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..153
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..219
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..244
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..303
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..327
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..391
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 339
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 130..208
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 391 AA; 42686 MW; 85C99AFFF339A43D CRC64;
MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT LSEGQGSAIL
ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL AIADELLMLS VPFLVTSTLL
RHWPFGALLC RLVLSVDAVN MFTSIYCLTV LSVDRYVAVV HPIKAARYRR PTVAKVVNLG
VWVLSLLVIL PIVVFSRTAA NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC
LCYVLIIAKM RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP VDYYATALKS
RAYSVEDFQP ENLESGGVFR NGTCTSRITT L
