SSR4_MOUSE
ID SSR4_MOUSE Reviewed; 385 AA.
AC P49660; Q8BQ97;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=Somatostatin receptor type 4;
DE Short=SS-4-R;
DE Short=SS4-R;
DE Short=SS4R;
GN Name=Sstr4; Synonyms=Smstr4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ; TISSUE=Liver;
RX PubMed=8654950; DOI=10.1016/0378-1119(95)00748-2;
RA Schwabe W., Brennan M.B., Hochgeschwender U.;
RT "Isolation and characterization of the mouse (Mus musculus) somatostatin
RT receptor type-4-encoding gene (mSSTR4).";
RL Gene 168:233-235(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CAST/EiJ; TISSUE=Brain;
RX PubMed=16670015; DOI=10.1186/1471-2164-7-102;
RA Farber C.R., Corva P.M., Medrano J.F.;
RT "Genome-wide isolation of growth and obesity QTL using mouse speed congenic
RT strains.";
RL BMC Genomics 7:102-102(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for somatostatin-14. The activity of this receptor
CC is mediated by G proteins which inhibits adenylyl cyclase. It is
CC functionally coupled not only to inhibition of adenylate cyclase, but
CC also to activation of both arachidonate release and mitogen-activated
CC protein (MAP) kinase cascade.
CC -!- INTERACTION:
CC P49660; Q62108: Dlg4; NbExp=3; IntAct=EBI-7665342, EBI-300895;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U26176; AAA67561.1; -; Genomic_DNA.
DR EMBL; AY902332; AAX90617.1; -; Genomic_DNA.
DR EMBL; AK051189; BAC34552.1; -; mRNA.
DR EMBL; AL935149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC138487; AAI38488.1; -; mRNA.
DR EMBL; BC138488; AAI38489.1; -; mRNA.
DR CCDS; CCDS38260.1; -.
DR PIR; JC4629; JC4629.
DR RefSeq; NP_033245.2; NM_009219.3.
DR AlphaFoldDB; P49660; -.
DR SMR; P49660; -.
DR IntAct; P49660; 2.
DR MINT; P49660; -.
DR STRING; 10090.ENSMUSP00000105588; -.
DR BindingDB; P49660; -.
DR ChEMBL; CHEMBL4397; -.
DR DrugCentral; P49660; -.
DR GuidetoPHARMACOLOGY; 358; -.
DR GlyGen; P49660; 1 site.
DR PhosphoSitePlus; P49660; -.
DR SwissPalm; P49660; -.
DR PaxDb; P49660; -.
DR PRIDE; P49660; -.
DR ABCD; P49660; 22 sequenced antibodies.
DR DNASU; 20608; -.
DR GeneID; 20608; -.
DR KEGG; mmu:20608; -.
DR UCSC; uc008mtc.1; mouse.
DR CTD; 6754; -.
DR MGI; MGI:105372; Sstr4.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P49660; -.
DR OrthoDB; 1011272at2759; -.
DR TreeFam; TF315737; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 20608; 0 hits in 72 CRISPR screens.
DR PRO; PR:P49660; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P49660; protein.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0004994; F:somatostatin receptor activity; ISO:MGI.
DR GO; GO:0016477; P:cell migration; ISO:MGI.
DR GO; GO:0071385; P:cellular response to glucocorticoid stimulus; IBA:GO_Central.
DR GO; GO:0106072; P:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0090238; P:positive regulation of arachidonic acid secretion; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000586; Somatstn_rcpt.
DR InterPro; IPR001512; Somatstn_rcpt_4.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00246; SOMATOSTATNR.
DR PRINTS; PR00590; SOMATOSTTN4R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..385
FT /note="Somatostatin receptor type 4"
FT /id="PRO_0000070128"
FT TOPO_DOM 1..42
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..70
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..106
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..281
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..312
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..385
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 324
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 116..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 8..9
FT /note="PP -> LR (in Ref. 1; AAA67561)"
FT /evidence="ECO:0000305"
FT CONFLICT 27..29
FT /note="DEE -> EQ (in Ref. 1; AAA67561)"
FT /evidence="ECO:0000305"
FT CONFLICT 100
FT /note="A -> V (in Ref. 1; AAA67561)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="A -> R (in Ref. 1; AAA67561)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="A -> R (in Ref. 1; AAA67561)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 385 AA; 41932 MW; 64B3A272947A81BC CRC64;
MNAPATLPPG VEDTTWTPGI NASWAPDEEE EDAMGSDGTG TAGMVTIQCI YALVCLVGLV
GNALVIFVIL RYAKMKTATN IYLLNLAVAD ELFMLSVPFA RSAAALRHWP FGAVLCRAVL
SVDGLNMFTS VFCLTVLSVD RYVAVVHPLA TATYRRPSVA KLINLGVWLA SLLVTLPIAV
FADTRPARGG EAVACNLHWP HPAWSAVFVI YTFLLGFLPP VLAIGLCYLL IVGKMRAVAL
AGGWQQRRRS EKKITRLVLM VVTVFVLCWM PFYVVQLLNL FVTSLDATVN HVSLILSYAN
SCANPILYGF LSDNFRRSFQ RVLCLRCCLL ETTGGAEEEP LDYYATALKS RGGAGCICPP
LPCQQEPVQA EPGCKQVPFT KTTTF
