ID   SSRD_MOUSE              Reviewed;         172 AA.
AC   Q62186;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Translocon-associated protein subunit delta;
DE            Short=TRAP-delta;
DE   AltName: Full=Signal sequence receptor subunit delta;
DE            Short=SSR-delta;
DE   Flags: Precursor;
GN   Name=Ssr4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=7492314; DOI=10.1042/bj3120205;
RA   Holthuis J.C.M., van Riel M.C.H.M., Martens G.J.M.;
RT   "Translocon-associated protein TRAP delta and a novel TRAP-like protein are
RT   coordinately expressed with pro-opiomelanocortin in Xenopus intermediate
RT   pituitary.";
RL   Biochem. J. 312:205-213(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Platzer M., Brenner V., Reichwald K., Wiehe T., Oksche A., Rosenthal A.;
RT   "Comparative sequence analysis of the mouse L1cam locus and the
RT   corresponding region of human Xq28.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: TRAP proteins are part of a complex whose function is to bind
CC       calcium to the ER membrane and thereby regulate the retention of ER
CC       resident proteins. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-
CC       gamma. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAP-delta family. {ECO:0000305}.
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DR   EMBL; X90582; CAA62210.1; -; mRNA.
DR   EMBL; AF133093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS30213.1; -.
DR   PIR; S59864; S59864.
DR   RefSeq; NP_033305.1; NM_009279.3.
DR   AlphaFoldDB; Q62186; -.
DR   BioGRID; 203511; 9.
DR   IntAct; Q62186; 2.
DR   MINT; Q62186; -.
DR   STRING; 10090.ENSMUSP00000002090; -.
DR   iPTMnet; Q62186; -.
DR   PhosphoSitePlus; Q62186; -.
DR   SwissPalm; Q62186; -.
DR   EPD; Q62186; -.
DR   jPOST; Q62186; -.
DR   MaxQB; Q62186; -.
DR   PaxDb; Q62186; -.
DR   PRIDE; Q62186; -.
DR   ProteomicsDB; 257422; -.
DR   Antibodypedia; 30981; 166 antibodies from 25 providers.
DR   DNASU; 20832; -.
DR   Ensembl; ENSMUST00000002090; ENSMUSP00000002090; ENSMUSG00000002014.
DR   GeneID; 20832; -.
DR   KEGG; mmu:20832; -.
DR   UCSC; uc009tmr.2; mouse.
DR   CTD; 6748; -.
DR   MGI; MGI:1099464; Ssr4.
DR   VEuPathDB; HostDB:ENSMUSG00000002014; -.
DR   eggNOG; KOG4088; Eukaryota.
DR   GeneTree; ENSGT00390000008992; -.
DR   HOGENOM; CLU_100264_0_1_1; -.
DR   InParanoid; Q62186; -.
DR   TreeFam; TF313158; -.
DR   BioGRID-ORCS; 20832; 2 hits in 70 CRISPR screens.
DR   ChiTaRS; Ssr4; mouse.
DR   PRO; PR:Q62186; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q62186; protein.
DR   Bgee; ENSMUSG00000002014; Expressed in seminal vesicle and 267 other tissues.
DR   ExpressionAtlas; Q62186; baseline and differential.
DR   Genevisible; Q62186; MM.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005784; C:Sec61 translocon complex; ISO:MGI.
DR   InterPro; IPR008855; TRAP-delta.
DR   PANTHER; PTHR12731; PTHR12731; 1.
DR   Pfam; PF05404; TRAP-delta; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Endoplasmic reticulum; Isopeptide bond; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Ubl conjugation.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..172
FT                   /note="Translocon-associated protein subunit delta"
FT                   /id="PRO_0000033293"
FT   TOPO_DOM        24..143
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..172
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        25..56
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        72
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250|UniProtKB:P51571"
SQ   SEQUENCE   172 AA;  18937 MW;  AA8A9B9147046649 CRC64;
     MAAMASFGAL ALLLLSGLSC CSEACLEPQI TPSYYTTSDA VISTETVFIV EISLTCKNRV
     QNMALYADVS GKQFPVTRGQ DVGRYQVSWS LEHKSAHAGT YEVRFFDEES YSLLRKAQRN
     NEDVSIIPPL FTVSVDHRGT WNGPWVSTEV LAAVIGIVIY YLAFSAKSHI QA