ID   SSRD_RAT                Reviewed;         173 AA.
AC   Q07984;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Translocon-associated protein subunit delta;
DE            Short=TRAP-delta;
DE   AltName: Full=Signal sequence receptor subunit delta;
DE            Short=SSR-delta;
DE   Flags: Precursor;
GN   Name=Ssr4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=7916687; DOI=10.1111/j.1432-1033.1993.tb17933.x;
RA   Hartmann E., Goerlich D., Kostka S., Otto A., Kraft R., Knespel S.,
RA   Buerger E., Rapoport T.A., Prehn S.;
RT   "A tetrameric complex of membrane proteins in the endoplasmic reticulum.";
RL   Eur. J. Biochem. 214:375-381(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: TRAP proteins are part of a complex whose function is to bind
CC       calcium to the ER membrane and thereby regulate the retention of ER
CC       resident proteins.
CC   -!- SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-
CC       gamma.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type
CC       I membrane protein.
CC   -!- SIMILARITY: Belongs to the TRAP-delta family. {ECO:0000305}.
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DR   EMBL; Z19087; CAA79513.1; -; mRNA.
DR   EMBL; BC058482; AAH58482.1; -; mRNA.
DR   PIR; S33295; S33295.
DR   RefSeq; NP_058895.1; NM_017199.1.
DR   AlphaFoldDB; Q07984; -.
DR   BioGRID; 248082; 1.
DR   IntAct; Q07984; 2.
DR   STRING; 10116.ENSRNOP00000063309; -.
DR   jPOST; Q07984; -.
DR   PaxDb; Q07984; -.
DR   PRIDE; Q07984; -.
DR   GeneID; 29435; -.
DR   KEGG; rno:29435; -.
DR   CTD; 6748; -.
DR   RGD; 62034; Ssr4.
DR   VEuPathDB; HostDB:ENSRNOG00000053172; -.
DR   eggNOG; KOG4088; Eukaryota.
DR   HOGENOM; CLU_100264_0_1_1; -.
DR   InParanoid; Q07984; -.
DR   OMA; GPWVNSE; -.
DR   OrthoDB; 1518302at2759; -.
DR   PRO; PR:Q07984; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000053172; Expressed in pancreas and 20 other tissues.
DR   Genevisible; Q07984; RN.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; TAS:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005784; C:Sec61 translocon complex; IDA:RGD.
DR   InterPro; IPR008855; TRAP-delta.
DR   PANTHER; PTHR12731; PTHR12731; 1.
DR   Pfam; PF05404; TRAP-delta; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endoplasmic reticulum; Isopeptide bond; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Ubl conjugation.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..173
FT                   /note="Translocon-associated protein subunit delta"
FT                   /id="PRO_0000033295"
FT   TOPO_DOM        24..144
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..173
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        26..57
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        73
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250|UniProtKB:P51571"
SQ   SEQUENCE   173 AA;  18980 MW;  CE673433DCD47EBB CRC64;
     MAAMASFGAL ALLLLSGLSC CSAEACLEPQ ITPSYYTTSD AVISTETVFI VEISLTCKNR
     VQNMALYADV SGKQFPVTRG QDVGRYQVSW SLEHKSAHAG TYEVRFFDEE SYSLLRKAQR
     NNEDVSIIPP LFTVSVDHRG TWNGPWVSTE VLAAAIGIVI YYLAFSAKSH IQA