SSRG_PONAB
ID SSRG_PONAB Reviewed; 185 AA.
AC Q5RCD7;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Translocon-associated protein subunit gamma;
DE Short=TRAP-gamma;
DE AltName: Full=Signal sequence receptor subunit gamma;
DE Short=SSR-gamma;
GN Name=SSR3;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: TRAP proteins are part of a complex whose function is to bind
CC calcium to the ER membrane and thereby regulate the retention of ER
CC resident proteins. {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-
CC gamma. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAP-gamma family. {ECO:0000305}.
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DR EMBL; CR858334; CAH90570.1; -; mRNA.
DR RefSeq; NP_001127303.1; NM_001133831.1.
DR AlphaFoldDB; Q5RCD7; -.
DR STRING; 9601.ENSPPYP00000015913; -.
DR Ensembl; ENSPPYT00000016546; ENSPPYP00000015913; ENSPPYG00000014233.
DR GeneID; 100174364; -.
DR KEGG; pon:100174364; -.
DR CTD; 6747; -.
DR eggNOG; KOG4490; Eukaryota.
DR GeneTree; ENSGT00390000000970; -.
DR HOGENOM; CLU_092935_0_0_1; -.
DR InParanoid; Q5RCD7; -.
DR OMA; TKFTLKH; -.
DR TreeFam; TF314998; -.
DR Proteomes; UP000001595; Chromosome 3.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR InterPro; IPR009779; SSR3.
DR PANTHER; PTHR13399; PTHR13399; 1.
DR Pfam; PF07074; TRAP-gamma; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Endoplasmic reticulum; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..185
FT /note="Translocon-associated protein subunit gamma"
FT /id="PRO_0000191692"
FT TOPO_DOM 1..27
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..135
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..163
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9UNL2"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UNL2"
FT MOD_RES 105
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9DCF9"
SQ SEQUENCE 185 AA; 21097 MW; CEF0BD264F9E50ED CRC64;
MAPKGSCKQQ SEEDLLLQDF SRNLSAKSSA LFFGNAFIVS AIPIWLYWRI WHMDLIQSAV
LYSVMTLVST YLVAFAYKNV KFVLKHKVAQ KREDAVSKEV TRKLSEADNR KMSRKEKDER
ILWKKNEVAD YEATTFSIFY NNTLFLVVVI VASFFILKNF NPTVNYILSI SASSGLIALL
STGSK
