ID   SSSP_PLAFO              Reviewed;         157 AA.
AC   P17503; Q25997;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Sexual stage-specific protein;
DE   Flags: Precursor;
OS   Plasmodium falciparum (isolate NF54).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Alano P., Bhatti S., Smith D.K., Bruce M.C., Carter R., Elliott J.F.;
RL   Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2038355; DOI=10.1016/0166-6851(91)90086-l;
RA   Moelans I.M.D., Meis J.F.G.M., Kocken C., Konings R.N.H.,
RA   Schoenmakers J.G.G.;
RT   "A novel protein antigen of the malaria parasite Plasmodium falciparum,
RT   located on the surface of gametes and sporozoites.";
RL   Mol. Biochem. Parasitol. 45:193-204(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-157.
RX   PubMed=2129551; DOI=10.1093/nar/18.12.3637;
RA   Bruce M.C., Baker D.A., Alano P., Rogers N.C., Graves P.M., Targett G.A.T.,
RA   Carter R.;
RT   "Sequence coding for a sexual stage specific protein of Plasmodium
RT   falciparum.";
RL   Nucleic Acids Res. 18:3637-3637(1990).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Gametocyte.
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DR   EMBL; M64107; AAA29454.1; -; mRNA.
DR   EMBL; M64705; AAA29733.1; -; mRNA.
DR   EMBL; X53030; CAA37203.1; -; Genomic_DNA.
DR   PIR; S30129; S30129.
DR   AlphaFoldDB; P17503; -.
DR   SMR; P17503; -.
DR   PRIDE; P17503; -.
DR   VEuPathDB; PlasmoDB:PfNF54_040011900; -.
DR   OMA; MNAKNLM; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006389; ETRAMP.
DR   Pfam; PF09716; ETRAMP; 1.
PE   2: Evidence at transcript level;
KW   Malaria; Membrane; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..157
FT                   /note="Sexual stage-specific protein"
FT                   /id="PRO_0000024628"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          30..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..148
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        61
FT                   /note="Q -> L (in Ref. 2; AAA29733)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        116
FT                   /note="M -> MIK (in Ref. 2; AAA29733)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   157 AA;  16626 MW;  7B1AB2958B8B266D CRC64;
     MNIRKFIPSL ALMLIFFAFA NLVLSDANDK AKKPAGKGSP STLQTPGSSS GASLHAVGPN
     QGGLSQGLSG KDSADKMPLE TQLAIEEIKS LSNMLDKKTT VNRNLIISTA VTNMIMLIIL
     SGIVGFKVKK TKNADDDKGD KDKDKDNTDE GDEGDDS