SSU72_DANRE
ID SSU72_DANRE Reviewed; 194 AA.
AC Q6PC19;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=RNA polymerase II subunit A C-terminal domain phosphatase SSU72;
DE Short=CTD phosphatase SSU72;
DE EC=3.1.3.16;
GN Name=ssu72; ORFNames=zgc:73143;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Wild-type; TISSUE=Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in the C-terminal domain of RNA polymerase II
CC dephosphorylation, RNA processing and termination. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Predominantly in the cytosol. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SSU72 phosphatase family. {ECO:0000305}.
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DR EMBL; BC059504; AAH59504.1; -; mRNA.
DR RefSeq; NP_957022.1; NM_200728.1.
DR AlphaFoldDB; Q6PC19; -.
DR SMR; Q6PC19; -.
DR STRING; 7955.ENSDARP00000041894; -.
DR PaxDb; Q6PC19; -.
DR Ensembl; ENSDART00000041895; ENSDARP00000041894; ENSDARG00000031216.
DR GeneID; 393701; -.
DR KEGG; dre:393701; -.
DR CTD; 29101; -.
DR ZFIN; ZDB-GENE-040426-1689; ssu72.
DR eggNOG; KOG2424; Eukaryota.
DR GeneTree; ENSGT00390000010165; -.
DR HOGENOM; CLU_062463_2_1_1; -.
DR InParanoid; Q6PC19; -.
DR OMA; PNCYEFG; -.
DR OrthoDB; 1304061at2759; -.
DR PhylomeDB; Q6PC19; -.
DR TreeFam; TF300194; -.
DR Reactome; R-DRE-6807505; RNA polymerase II transcribes snRNA genes.
DR PRO; PR:Q6PC19; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 22.
DR Bgee; ENSDARG00000031216; Expressed in granulocyte and 30 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008420; F:RNA polymerase II CTD heptapeptide repeat phosphatase activity; IBA:GO_Central.
DR GO; GO:0070940; P:dephosphorylation of RNA polymerase II C-terminal domain; IBA:GO_Central.
DR GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR InterPro; IPR006811; RNA_pol_II_suA.
DR PANTHER; PTHR20383; PTHR20383; 1.
DR Pfam; PF04722; Ssu72; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Hydrolase; mRNA processing; Nucleus;
KW Protein phosphatase; Reference proteome.
FT CHAIN 1..194
FT /note="RNA polymerase II subunit A C-terminal domain
FT phosphatase SSU72"
FT /id="PRO_0000330016"
FT COILED 160..185
FT /evidence="ECO:0000255"
SQ SEQUENCE 194 AA; 22793 MW; 288F8BE70DBD7880 CRC64;
MPPHPLRVAV VCSSNQNRSM EAHNILSKRG FDVRSFGTGT HVKLPGPAPD KPNIYDFKTT
YEQMYNDLVR KDKELYTQNG ILHMLDRNKR IKSRPERFQS CRDQFDLVIT CEERVYDQVL
EDLNSREQES FQPVHVINVD IQDNHEEATL GAFLICELCQ CIQHTDDMEN EMDELLQEFE
EKSHRPFLHS VCFY
