ID   SSUR_BURCJ              Reviewed;         308 AA.
AC   B4E8S9;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=HTH-type transcriptional regulator SsuR {ECO:0000305};
GN   Name=ssuR {ECO:0000303|PubMed:16997956};
GN   ORFNames=BCAL1656 {ECO:0000312|EMBL:CAR51955.1};
OS   Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 /
OS   NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=216591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610;
RX   PubMed=18931103; DOI=10.1128/jb.01230-08;
RA   Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M., Bentley S.D.,
RA   Cerdeno-Tarraga A.M., Thomson N.R., Bason N., Quail M.A., Sharp S.,
RA   Cherevach I., Churcher C., Goodhead I., Hauser H., Holroyd N., Mungall K.,
RA   Scott P., Walker D., White B., Rose H., Iversen P., Mil-Homens D.,
RA   Rocha E.P., Fialho A.M., Baldwin A., Dowson C., Barrell B.G., Govan J.R.,
RA   Vandamme P., Hart C.A., Mahenthiralingam E., Parkhill J.;
RT   "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of
RT   cystic fibrosis patients.";
RL   J. Bacteriol. 191:261-277(2009).
RN   [2]
RP   FUNCTION, DNA-BINDING, AND DISRUPTION PHENOTYPE.
RC   STRAIN=715j;
RX   PubMed=16997956; DOI=10.1128/jb.00592-06;
RA   Iwanicka-Nowicka R., Zielak A., Cook A.M., Thomas M.S., Hryniewicz M.M.;
RT   "Regulation of sulfur assimilation pathways in Burkholderia cenocepacia:
RT   identification of transcription factors CysB and SsuR and their role in
RT   control of target genes.";
RL   J. Bacteriol. 189:1675-1688(2007).
RN   [3]
RP   FUNCTION, AND DNA-BINDING.
RC   STRAIN=715j;
RX   PubMed=21317335; DOI=10.1128/jb.00483-10;
RA   Lochowska A., Iwanicka-Nowicka R., Zielak A., Modelewska A., Thomas M.S.,
RA   Hryniewicz M.M.;
RT   "Regulation of sulfur assimilation pathways in Burkholderia cenocepacia
RT   through control of genes by the SsuR transcription factor.";
RL   J. Bacteriol. 193:1843-1853(2011).
CC   -!- FUNCTION: Transcriptional regulator that is essential for the
CC       utilization of a number of organic sulfur sources of either
CC       environmental or human origin (PubMed:21317335). Required for aliphatic
CC       sulfonate utilization (PubMed:16997956). Binds to DNA at target
CC       promoter regions (PubMed:16997956, PubMed:21317335). Targets include
CC       the ssuDBC operon, the tauABC operon, three tauD-type genes and atsA
CC       (PubMed:16997956, PubMed:21317335). {ECO:0000269|PubMed:16997956,
CC       ECO:0000269|PubMed:21317335}.
CC   -!- DISRUPTION PHENOTYPE: Mutant grows well with sulfate, but is unable to
CC       utilize ethanesulfonate as a sulfur source.
CC       {ECO:0000269|PubMed:16997956}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AM747720; CAR51955.1; -; Genomic_DNA.
DR   RefSeq; WP_006484201.1; NC_011000.1.
DR   AlphaFoldDB; B4E8S9; -.
DR   SMR; B4E8S9; -.
DR   STRING; 216591.BCAL1656; -.
DR   EnsemblBacteria; CAR51955; CAR51955; BCAL1656.
DR   GeneID; 61086025; -.
DR   KEGG; bcj:BCAL1656; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_2_4; -.
DR   OMA; FERYGKR; -.
DR   OrthoDB; 990666at2; -.
DR   BioCyc; BCEN216591:G1G1V-1836-MON; -.
DR   Proteomes; UP000001035; Chromosome 1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08413; PBP2_CysB_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037423; CysB_PBP2.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..308
FT                   /note="HTH-type transcriptional regulator SsuR"
FT                   /id="PRO_0000445023"
FT   DOMAIN          1..59
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   308 AA;  34422 MW;  090E7D363B350AA8 CRC64;
     MNFQQLRFVR EAVRQNMNLT EVANVLYTSQ SGVSKQIKDL EDELGVDIFI RRGKRLTGLT
     EPGKAVHQLI ERMLLDAENL RRVARQFADQ DSGHLVVATT HTQARYALPK VIRQFTDVFP
     KVHLALRQGS PQQIAQMILN GEADLGISTE ALDRYPDIVT FPCYSWHHTV VVPKGHPLVG
     RENLTLEEIA EYPIITYDQD FTGRSHIDQA FTQAGAVPDV VLTAIDADVI KTYVELGMGI
     GVVAAMAYDP QRDTGLVALD TQHLFEASTT RVGLRKGAFL RAYAYRLIEM FAPHLNEAEI
     AGLLREAV