SSX5_HUMAN
ID SSX5_HUMAN Reviewed; 188 AA.
AC O60225; Q5JQ59; Q5JQ60; Q96AW3;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 3.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Protein SSX5;
GN Name=SSX5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT GLN-19.
RX PubMed=9378559;
RX DOI=10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n;
RA Gure A.O., Tuereci O., Sahin U., Tsang S., Scanlan M.J., Jager E.,
RA Knuth A., Pfreundschuh M., Old L.J., Chen Y.-T.;
RT "SSX: a multigene family with several members transcribed in normal testis
RT and human cancer.";
RL Int. J. Cancer 72:965-971(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT GLN-19.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could act as a modulator of transcription.
CC -!- INTERACTION:
CC O60225; Q6RW13: AGTRAP; NbExp=5; IntAct=EBI-10186198, EBI-741181;
CC O60225-2; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-12033476, EBI-11522760;
CC O60225-2; Q6PJH3: AKAP9; NbExp=3; IntAct=EBI-12033476, EBI-11745576;
CC O60225-2; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-12033476, EBI-11522780;
CC O60225-2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-12033476, EBI-5916454;
CC O60225-2; P08247: SYP; NbExp=3; IntAct=EBI-12033476, EBI-9071725;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O60225-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O60225-2; Sequence=VSP_006274;
CC -!- SIMILARITY: Belongs to the SSX family. {ECO:0000305}.
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DR EMBL; U90842; AAC05821.1; -; mRNA.
DR EMBL; AL683817; CAI41133.1; -; Genomic_DNA.
DR EMBL; AL356464; CAI41133.1; JOINED; Genomic_DNA.
DR EMBL; AL683817; CAI41134.1; -; Genomic_DNA.
DR EMBL; AL356464; CAI41134.1; JOINED; Genomic_DNA.
DR EMBL; AL356464; CAI40523.1; -; Genomic_DNA.
DR EMBL; AL683817; CAI40523.1; JOINED; Genomic_DNA.
DR EMBL; AL356464; CAI40524.1; -; Genomic_DNA.
DR EMBL; AL683817; CAI40524.1; JOINED; Genomic_DNA.
DR EMBL; BC016640; AAH16640.1; -; mRNA.
DR CCDS; CCDS14288.1; -. [O60225-2]
DR CCDS; CCDS14289.1; -. [O60225-1]
DR RefSeq; NP_066295.3; NM_021015.3. [O60225-2]
DR RefSeq; NP_783729.1; NM_175723.1. [O60225-1]
DR RefSeq; XP_011542251.1; XM_011543949.2. [O60225-1]
DR RefSeq; XP_016885247.1; XM_017029758.1. [O60225-1]
DR AlphaFoldDB; O60225; -.
DR BioGRID; 112636; 10.
DR IntAct; O60225; 9.
DR iPTMnet; O60225; -.
DR PhosphoSitePlus; O60225; -.
DR BioMuta; SSX5; -.
DR MassIVE; O60225; -.
DR PeptideAtlas; O60225; -.
DR PRIDE; O60225; -.
DR ProteomicsDB; 49250; -. [O60225-1]
DR ProteomicsDB; 49251; -. [O60225-2]
DR Antibodypedia; 25586; 296 antibodies from 23 providers.
DR DNASU; 6758; -.
DR Ensembl; ENST00000311798.5; ENSP00000312415.1; ENSG00000165583.16. [O60225-2]
DR Ensembl; ENST00000347757.6; ENSP00000290558.1; ENSG00000165583.16. [O60225-1]
DR GeneID; 6758; -.
DR KEGG; hsa:6758; -.
DR MANE-Select; ENST00000347757.6; ENSP00000290558.1; NM_175723.2; NP_783729.1.
DR UCSC; uc004diz.1; human. [O60225-1]
DR CTD; 6758; -.
DR DisGeNET; 6758; -.
DR GeneCards; SSX5; -.
DR HGNC; HGNC:11339; SSX5.
DR HPA; ENSG00000165583; Tissue enhanced (brain).
DR MIM; 300327; gene.
DR neXtProt; NX_O60225; -.
DR OpenTargets; ENSG00000165583; -.
DR PharmGKB; PA36163; -.
DR VEuPathDB; HostDB:ENSG00000165583; -.
DR GeneTree; ENSGT00390000012484; -.
DR InParanoid; O60225; -.
DR OMA; DISKYIC; -.
DR OrthoDB; 1270676at2759; -.
DR PhylomeDB; O60225; -.
DR TreeFam; TF338517; -.
DR PathwayCommons; O60225; -.
DR SignaLink; O60225; -.
DR BioGRID-ORCS; 6758; 64 hits in 686 CRISPR screens.
DR ChiTaRS; SSX5; human.
DR GeneWiki; SSX5; -.
DR GenomeRNAi; 6758; -.
DR Pharos; O60225; Tdark.
DR PRO; PR:O60225; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O60225; protein.
DR Bgee; ENSG00000165583; Expressed in right uterine tube and 37 other tissues.
DR Genevisible; O60225; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR003655; aKRAB.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR028804; SSX.
DR InterPro; IPR019041; SSXRD_motif.
DR PANTHER; PTHR14112; PTHR14112; 1.
DR Pfam; PF09514; SSXRD; 1.
DR SMART; SM00349; KRAB; 1.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50806; KRAB_RELATED; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..188
FT /note="Protein SSX5"
FT /id="PRO_0000181832"
FT DOMAIN 20..83
FT /note="KRAB-related"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00120"
FT REGION 78..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 23
FT /note="K -> KHPWRQVCDRGIHLVNLSPFWKVGREPASSIKALLCGRGEAR (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_006274"
FT VARIANT 19
FT /note="E -> Q (in dbSNP:rs4824675)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9378559"
FT /id="VAR_027805"
FT CONFLICT 184
FT /note="Q -> P (in Ref. 1; AAC05821)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 188 AA; 21660 MW; DBFA61D8B1295A27 CRC64;
MNGDDAFVRR PRVGSQIPEK MQKAFDDIAK YFSEKEWEKM KASEKIIYVY MKRKYEAMTK
LGFKATLPPF MRNKRVADFQ GNDFDNDPNR GNQVEHPQMT FGRLQGIFPK ITPEKPAEEG
NDSKGVPEAS GPQNNGKQLR PSGKLNTSEK VNKTSGPKRG KHAWTHRVRE RKQLVIYEEI
SDPQEDDE
