SSX6_HUMAN
ID SSX6_HUMAN Reviewed; 188 AA.
AC Q7RTT6;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Putative protein SSX6;
GN Name=SSX6P {ECO:0000312|HGNC:HGNC:19652}; Synonyms=SSX6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12216073; DOI=10.1002/ijc.10634;
RA Gure A.O., Wei I.J., Old L.J., Chen Y.-T.;
RT "The SSX gene family: characterization of 9 complete genes.";
RL Int. J. Cancer 101:448-453(2002).
CC -!- FUNCTION: Could act as a modulator of transcription.
CC -!- TISSUE SPECIFICITY: Not detected in any normal tissues. Expressed in a
CC melanoma cell line. {ECO:0000269|PubMed:12216073}.
CC -!- SIMILARITY: Belongs to the SSX family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL356464; CAI40525.1; -; Genomic_DNA.
DR EMBL; Z98304; CAI40525.1; JOINED; Genomic_DNA.
DR EMBL; BK000686; DAA00373.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7RTT6; -.
DR IntAct; Q7RTT6; 2.
DR iPTMnet; Q7RTT6; -.
DR PhosphoSitePlus; Q7RTT6; -.
DR BioMuta; HGNC:19652; -.
DR DMDM; 74759050; -.
DR MassIVE; Q7RTT6; -.
DR PaxDb; Q7RTT6; -.
DR PeptideAtlas; Q7RTT6; -.
DR PRIDE; Q7RTT6; -.
DR GeneCards; SSX6P; -.
DR HGNC; HGNC:19652; SSX6P.
DR MIM; 300541; gene.
DR neXtProt; NX_Q7RTT6; -.
DR InParanoid; Q7RTT6; -.
DR PhylomeDB; Q7RTT6; -.
DR TreeFam; TF338517; -.
DR PathwayCommons; Q7RTT6; -.
DR SignaLink; Q7RTT6; -.
DR Pharos; Q7RTT6; Tdark.
DR PRO; PR:Q7RTT6; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q7RTT6; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR003655; aKRAB.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR028804; SSX.
DR InterPro; IPR019041; SSXRD_motif.
DR PANTHER; PTHR14112; PTHR14112; 1.
DR Pfam; PF09514; SSXRD; 1.
DR SMART; SM00349; KRAB; 1.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50806; KRAB_RELATED; 1.
PE 5: Uncertain;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..188
FT /note="Putative protein SSX6"
FT /id="PRO_0000227810"
FT DOMAIN 20..83
FT /note="KRAB-related"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00120"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q16384"
FT VARIANT 90
FT /note="R -> C (in dbSNP:rs5952474)"
FT /id="VAR_053692"
FT VARIANT 138
FT /note="K -> Q (in dbSNP:rs17327911)"
FT /id="VAR_053693"
SQ SEQUENCE 188 AA; 21688 MW; BBAB5A4F7BA879C8 CRC64;
MNGDDAFAKR PRDDAKASEK RSKAFDDIAK YFSKEEWEKM KFSEKISCVH MKRKYEAMTK
LGFNVTLSLF MRNKRATDSQ RNDSDNDRNR GNEVERPQMT FGRLQRIIPK IMPEKPAEEG
SDSKGVPEAS GPQNDGKKLC PPGKASSSEK IHERSGPKRG KHAWTHRLRE RKQLVIYEEI
SDPEEDDK
