SSX7_HUMAN
ID SSX7_HUMAN Reviewed; 188 AA.
AC Q7RTT5;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein SSX7;
GN Name=SSX7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12216073; DOI=10.1002/ijc.10634;
RA Gure A.O., Wei I.J., Old L.J., Chen Y.-T.;
RT "The SSX gene family: characterization of 9 complete genes.";
RL Int. J. Cancer 101:448-453(2002).
CC -!- FUNCTION: Could act as a modulator of transcription.
CC -!- INTERACTION:
CC Q7RTT5; Q99828: CIB1; NbExp=5; IntAct=EBI-12879730, EBI-372594;
CC Q7RTT5; Q86X45: DNAAF11; NbExp=3; IntAct=EBI-12879730, EBI-9379658;
CC Q7RTT5; Q96CN5: LRRC45; NbExp=3; IntAct=EBI-12879730, EBI-2805176;
CC Q7RTT5; Q9UHV2: SERTAD1; NbExp=3; IntAct=EBI-12879730, EBI-748601;
CC -!- TISSUE SPECIFICITY: Testis-specific. Expressed in a melanoma cell line.
CC {ECO:0000269|PubMed:12216073}.
CC -!- SIMILARITY: Belongs to the SSX family. {ECO:0000305}.
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DR EMBL; AL450023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK000687; DAA00374.1; -; Genomic_DNA.
DR CCDS; CCDS14343.1; -.
DR RefSeq; NP_775494.1; NM_173358.2.
DR AlphaFoldDB; Q7RTT5; -.
DR BioGRID; 129378; 12.
DR IntAct; Q7RTT5; 6.
DR STRING; 9606.ENSP00000298181; -.
DR iPTMnet; Q7RTT5; -.
DR PhosphoSitePlus; Q7RTT5; -.
DR BioMuta; SSX7; -.
DR DMDM; 74749937; -.
DR MassIVE; Q7RTT5; -.
DR PaxDb; Q7RTT5; -.
DR PeptideAtlas; Q7RTT5; -.
DR PRIDE; Q7RTT5; -.
DR Antibodypedia; 12405; 64 antibodies from 12 providers.
DR DNASU; 280658; -.
DR Ensembl; ENST00000298181.6; ENSP00000298181.5; ENSG00000187754.9.
DR GeneID; 280658; -.
DR KEGG; hsa:280658; -.
DR MANE-Select; ENST00000298181.6; ENSP00000298181.5; NM_173358.2; NP_775494.1.
DR UCSC; uc004dqx.2; human.
DR CTD; 280658; -.
DR GeneCards; SSX7; -.
DR HGNC; HGNC:19653; SSX7.
DR HPA; ENSG00000187754; Tissue enhanced (brain).
DR MIM; 300542; gene.
DR neXtProt; NX_Q7RTT5; -.
DR OpenTargets; ENSG00000187754; -.
DR PharmGKB; PA134879420; -.
DR VEuPathDB; HostDB:ENSG00000187754; -.
DR eggNOG; ENOG502RU1A; Eukaryota.
DR GeneTree; ENSGT00390000012484; -.
DR HOGENOM; CLU_097196_1_0_1; -.
DR InParanoid; Q7RTT5; -.
DR OMA; EHIILRE; -.
DR OrthoDB; 1270676at2759; -.
DR PhylomeDB; Q7RTT5; -.
DR TreeFam; TF338517; -.
DR PathwayCommons; Q7RTT5; -.
DR SignaLink; Q7RTT5; -.
DR BioGRID-ORCS; 280658; 8 hits in 630 CRISPR screens.
DR GenomeRNAi; 280658; -.
DR Pharos; Q7RTT5; Tdark.
DR PRO; PR:Q7RTT5; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q7RTT5; protein.
DR Bgee; ENSG00000187754; Expressed in granulocyte and 18 other tissues.
DR ExpressionAtlas; Q7RTT5; baseline and differential.
DR Genevisible; Q7RTT5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR003655; aKRAB.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR028804; SSX.
DR InterPro; IPR019041; SSXRD_motif.
DR PANTHER; PTHR14112; PTHR14112; 1.
DR Pfam; PF09514; SSXRD; 1.
DR SMART; SM00349; KRAB; 1.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50806; KRAB_RELATED; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..188
FT /note="Protein SSX7"
FT /id="PRO_0000227811"
FT DOMAIN 20..83
FT /note="KRAB-related"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00120"
FT REGION 77..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q16384"
FT VARIANT 43
FT /note="L -> S (in dbSNP:rs3122210)"
FT /id="VAR_053694"
SQ SEQUENCE 188 AA; 21591 MW; 3871D4FAA13DC78E CRC64;
MNGDDAFARR PRAGAQIPEK IQKSFDDIAK YFSKKEWEKM KSLEKISYVY MKRKYEAMTK
LGFKATLPPF MHNTGATDLQ GNDFDNDRNQ GNQVERPQMT FCRLQRIFPK IMPKKPAEEG
NDSKGVPEAS GSQNDGKHLC PPGKPSTSEK INKTSGPKRG KHAWTHRLRE RKQLVIYEEI
SDPEEDDE
