ABHGB_HUMAN
ID ABHGB_HUMAN Reviewed; 469 AA.
AC Q9H3Z7;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein ABHD16B {ECO:0000305};
DE EC=3.-.-.-;
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 16B {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 16B {ECO:0000312|HGNC:HGNC:16128};
GN Name=ABHD16B {ECO:0000312|HGNC:HGNC:16128}; Synonyms=C20orf135;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD16 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL118506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13539.1; -.
DR RefSeq; NP_542189.1; NM_080622.3.
DR AlphaFoldDB; Q9H3Z7; -.
DR SMR; Q9H3Z7; -.
DR BioGRID; 126662; 17.
DR STRING; 9606.ENSP00000358932; -.
DR ESTHER; human-ABHD16B; ABHD16.
DR MEROPS; S09.B13; -.
DR iPTMnet; Q9H3Z7; -.
DR PhosphoSitePlus; Q9H3Z7; -.
DR BioMuta; ABHD16B; -.
DR DMDM; 23813959; -.
DR MassIVE; Q9H3Z7; -.
DR PaxDb; Q9H3Z7; -.
DR PeptideAtlas; Q9H3Z7; -.
DR PRIDE; Q9H3Z7; -.
DR ProteomicsDB; 80774; -.
DR TopDownProteomics; Q9H3Z7; -.
DR Antibodypedia; 70808; 8 antibodies from 6 providers.
DR DNASU; 140701; -.
DR Ensembl; ENST00000369916.5; ENSP00000358932.3; ENSG00000183260.7.
DR GeneID; 140701; -.
DR KEGG; hsa:140701; -.
DR MANE-Select; ENST00000369916.5; ENSP00000358932.3; NM_080622.4; NP_542189.1.
DR UCSC; uc002ygx.2; human.
DR CTD; 140701; -.
DR GeneCards; ABHD16B; -.
DR HGNC; HGNC:16128; ABHD16B.
DR HPA; ENSG00000183260; Tissue enhanced (testis).
DR neXtProt; NX_Q9H3Z7; -.
DR PharmGKB; PA25677; -.
DR VEuPathDB; HostDB:ENSG00000183260; -.
DR eggNOG; KOG1553; Eukaryota.
DR GeneTree; ENSGT00940000162803; -.
DR HOGENOM; CLU_040705_2_0_1; -.
DR InParanoid; Q9H3Z7; -.
DR OMA; FMDRRQH; -.
DR OrthoDB; 580247at2759; -.
DR PhylomeDB; Q9H3Z7; -.
DR TreeFam; TF314267; -.
DR PathwayCommons; Q9H3Z7; -.
DR SignaLink; Q9H3Z7; -.
DR BioGRID-ORCS; 140701; 12 hits in 1069 CRISPR screens.
DR ChiTaRS; ABHD16B; human.
DR GenomeRNAi; 140701; -.
DR Pharos; Q9H3Z7; Tdark.
DR PRO; PR:Q9H3Z7; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9H3Z7; protein.
DR Bgee; ENSG00000183260; Expressed in right testis and 95 other tissues.
DR Genevisible; Q9H3Z7; HS.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IBA:GO_Central.
DR GO; GO:0004620; F:phospholipase activity; IBA:GO_Central.
DR GO; GO:0052651; P:monoacylglycerol catabolic process; IBA:GO_Central.
DR GO; GO:0006660; P:phosphatidylserine catabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 3: Inferred from homology;
KW Hydrolase; Reference proteome.
FT CHAIN 1..469
FT /note="Protein ABHD16B"
FT /id="PRO_0000079463"
FT DOMAIN 174..298
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000255"
FT ACT_SITE 247
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 322
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 418
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT VARIANT 10
FT /note="L -> Q (in dbSNP:rs2281534)"
FT /id="VAR_050920"
SQ SEQUENCE 469 AA; 52555 MW; 85C72E84CCFFC9A1 CRC64;
MCVICFVKAL VRVFKIYLTA SYTYPFRGWP VAFRWDDVRA VGRSSSHRAL TCAAAAAGVW
LLRDETLGGD ALGRPPRGAR SQAQCLLQQL RELPGQLASY ALAHSLGRWL VYPGSVSLMT
RALLPLLQQG QERLVERYHG RRAKLVACDG NEIDTMFMDR RQHPGSHVHG PRLVICCEGN
AGFYEMGCLS APLEAGYSVL GWNHPGFGSS TGVPFPQHDA NAMDVVVEYA LHRLHFPPAH
LVVYGWSVGG FTATWATMTY PELGALVLDA TFDDLVPLAL KVMPHSWKGL VVRTVREHFN
LNVAEQLCCY PGPVLLLRRT QDDVVSTSGR LRPLSPGDVE GNRGNELLLR LLEHRYPVVM
AREGRAVVTR WLRAGSLAQE AAFYARYRVD EDWCLALLRS YRARCEEELE GEEALGPHGP
AFPWLVGQGL SSRRRRRLAL FLARKHLKNV EATHFSPLEP EEFQLPWRL
