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ST134_HUMAN
ID   ST134_HUMAN             Reviewed;         240 AA.
AC   Q8IZP2;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Putative protein FAM10A4;
DE   AltName: Full=Suppression of tumorigenicity 13 pseudogene 4;
GN   Name=ST13P4; Synonyms=FAM10A4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT LEU-71.
RX   PubMed=12079276; DOI=10.1006/geno.2002.6792;
RA   Sossey-Alaoui K., Kitamura E., Head K., Cowell J.K.;
RT   "Characterization of FAM10A4, a member of the ST13 tumor suppressor gene
RT   family that maps to the 13q14.3 region associated with B-Cell leukemia,
RT   multiple myeloma, and prostate cancer.";
RL   Genomics 80:5-7(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in bone marrow and weakly in
CC       placenta, pancreas, heart and HeLa cell line.
CC       {ECO:0000269|PubMed:12079276}.
CC   -!- SIMILARITY: Belongs to the FAM10 family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AF539468; AAN16377.1; -; mRNA.
DR   EMBL; AL157367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q8IZP2; -.
DR   SMR; Q8IZP2; -.
DR   IntAct; Q8IZP2; 7.
DR   iPTMnet; Q8IZP2; -.
DR   PhosphoSitePlus; Q8IZP2; -.
DR   SwissPalm; Q8IZP2; -.
DR   BioMuta; HGNC:18487; -.
DR   DMDM; 74762505; -.
DR   EPD; Q8IZP2; -.
DR   jPOST; Q8IZP2; -.
DR   MassIVE; Q8IZP2; -.
DR   MaxQB; Q8IZP2; -.
DR   PeptideAtlas; Q8IZP2; -.
DR   PRIDE; Q8IZP2; -.
DR   ProteomicsDB; 71392; -.
DR   GeneCards; ST13P4; -.
DR   HGNC; HGNC:18487; ST13P4.
DR   neXtProt; NX_Q8IZP2; -.
DR   InParanoid; Q8IZP2; -.
DR   PathwayCommons; Q8IZP2; -.
DR   SignaLink; Q8IZP2; -.
DR   Pharos; Q8IZP2; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8IZP2; protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd14438; Hip_N; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR034649; Hip_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF18253; HipN; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   5: Uncertain;
KW   Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..240
FT                   /note="Putative protein FAM10A4"
FT                   /id="PRO_0000190816"
FT   REPEAT          110..143
FT                   /note="TPR 1"
FT   REPEAT          145..177
FT                   /note="TPR 2"
FT   REPEAT          179..211
FT                   /note="TPR 3"
FT   REGION          38..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         71
FT                   /note="S -> L"
FT                   /evidence="ECO:0000269|PubMed:12079276"
FT                   /id="VAR_023644"
SQ   SEQUENCE   240 AA;  27407 MW;  6D2A849E530944E3 CRC64;
     MDPRKVNELR AFVKMCKKDP SILHTQEMRF LREWVESMGG TATQKAKSEE NTKEEKPDSK
     VEEDLKADEP SSEESDLEID KEGVIEPDTD APQEMGDENA EITEEVMDQA NDKKVAAIEA
     LNDGELQKAI DLFTDAIKLN PRLAILYAKR ASVFVKLQKP NAAIRDCDRA IEINPDSAQP
     YKRRGKAHRL LGHWEEAAHD LALACKFDYD EDASAMLKEV QPRAQKIAEH QRKYERKREE
 
 
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