ID   ST15B_HUMAN             Reviewed;         474 AA.
AC   X6R8R1;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   11-JUN-2014, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Synaptotagmin-15B {ECO:0000305};
GN   Name=SYT15B {ECO:0000312|HGNC:HGNC:51487};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
CC   -!- SIMILARITY: Belongs to the synaptotagmin family. {ECO:0000305}.
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DR   EMBL; FO681492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006718156.1; XM_006718093.3.
DR   SMR; X6R8R1; -.
DR   PeptideAtlas; X6R8R1; -.
DR   PRIDE; X6R8R1; -.
DR   Antibodypedia; 66340; 19 antibodies from 10 providers.
DR   UCSC; uc001jeb.4; human.
DR   HGNC; HGNC:51487; SYT15B.
DR   OpenTargets; ENSG00000204176; -.
DR   OpenTargets; ENSG00000277758; -.
DR   VEuPathDB; HostDB:ENSG00000204176; -.
DR   VEuPathDB; HostDB:ENSG00000277758; -.
DR   GeneTree; ENSGT00940000160819; -.
DR   OrthoDB; 925064at2759; -.
DR   PhylomeDB; X6R8R1; -.
DR   BioGRID-ORCS; 102724488; 0 hits in 3 CRISPR screens.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000204176; Expressed in right lung and 98 other tissues.
DR   ExpressionAtlas; X6R8R1; baseline and differential.
DR   Gene3D; 2.60.40.150; -; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR030539; SYT15.
DR   PANTHER; PTHR10024:SF234; PTHR10024:SF234; 1.
DR   Pfam; PF00168; C2; 2.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; SSF49562; 2.
DR   PROSITE; PS50004; C2; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat.
FT   CHAIN           1..474
FT                   /note="Synaptotagmin-15B"
FT                   /id="PRO_0000455537"
FT   DOMAIN          200..317
FT                   /note="C2 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          331..452
FT                   /note="C2 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          75..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   474 AA;  52213 MW;  4E53007807C357F8 CRC64;
     MGVVLSPHPA PSRREPLAPL APGTRPGWSP AVSGSSRSAL RPSTAGPGPG PGTGWGGTAA
     SGRWVPAPAV HCAAPRAAAG HQQHHGPPLC SPDGAPRRFK RRPGSPAPAA QTGETSLREQ
     PHGGPPAVPF VVPPTLQGRD WVPLHSGEWA DAPWDPCPAS ELLPHTSSGG LGDACMVGAI
     NPELYKFPED KSETDFPDGC LGRLWFSVEY EQEAERLLVG LIKAQHLQAP SETCSPLVKL
     YLLPDERRFL QSKTKRKTSN PQFDEHFIFQ VSSKTITQRV LKFSVYHVDR QRKHQLLGQV
     LFPLKNETLV GDCRRVIWRD LEAESLEPPS EFGDLQFCLS YNDYLSRLTV VVLRAKGLRL
     QEDRGIVSVF VKVSLMNHNK FVKCKKTSAV LGSINPVYNE TFSFKADATE LDTASLSLTV
     VQNMEGDKSQ QLGRVVVGPY MYTRGRELEH WDEMLSKPKE LVKRWHALCR TTEP