ST18_MOUSE
ID ST18_MOUSE Reviewed; 1045 AA.
AC Q80TY4; Q3UH00; Q3URH9; Q3UVB9; Q3UZN9; Q811B4; Q8K098;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Suppression of tumorigenicity 18 protein;
GN Name=St18; Synonyms=Kiaa0535;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Jandrig B., Seitz S., Hinzmann B., Arnold W.;
RT "ST18 is a breast cancer candidate tumor suppressor gene.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Brain, Cerebellum, Embryo, and Embryonic spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 289-1045.
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Repressor that binds to DNA sequences containing a bipartite
CC element consisting of a direct repeat of the sequence 5'-AAAGTTT-3'
CC separated by 2-9 nucleotides. Represses basal transcription activity
CC from target promoters (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MYT1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32273.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC65585.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ536155; CAD60089.1; -; mRNA.
DR EMBL; AK122303; BAC65585.1; ALT_INIT; mRNA.
DR EMBL; AK133743; BAE21817.1; -; mRNA.
DR EMBL; AK137440; BAE23351.1; -; mRNA.
DR EMBL; AK141513; BAE24709.1; -; mRNA.
DR EMBL; AK147320; BAE27844.1; -; mRNA.
DR EMBL; AK147664; BAE28057.1; -; mRNA.
DR EMBL; BC032273; AAH32273.1; ALT_INIT; mRNA.
DR CCDS; CCDS14810.1; -.
DR RefSeq; NP_001231621.1; NM_001244692.1.
DR RefSeq; NP_001231622.1; NM_001244693.1.
DR RefSeq; NP_776293.1; NM_173868.2.
DR RefSeq; XP_006495564.1; XM_006495501.3.
DR RefSeq; XP_006495565.1; XM_006495502.3.
DR RefSeq; XP_006495566.1; XM_006495503.3.
DR RefSeq; XP_006495567.1; XM_006495504.3.
DR RefSeq; XP_011236672.1; XM_011238370.1.
DR RefSeq; XP_011236673.1; XM_011238371.2.
DR RefSeq; XP_011236674.1; XM_011238372.2.
DR RefSeq; XP_011236675.1; XM_011238373.2.
DR AlphaFoldDB; Q80TY4; -.
DR SMR; Q80TY4; -.
DR BioGRID; 232229; 6.
DR STRING; 10090.ENSMUSP00000120298; -.
DR iPTMnet; Q80TY4; -.
DR PhosphoSitePlus; Q80TY4; -.
DR MaxQB; Q80TY4; -.
DR PaxDb; Q80TY4; -.
DR PRIDE; Q80TY4; -.
DR ProteomicsDB; 258630; -.
DR Antibodypedia; 24412; 234 antibodies from 26 providers.
DR DNASU; 240690; -.
DR Ensembl; ENSMUST00000043578; ENSMUSP00000042056; ENSMUSG00000033740.
DR Ensembl; ENSMUST00000131494; ENSMUSP00000117789; ENSMUSG00000033740.
DR Ensembl; ENSMUST00000140079; ENSMUSP00000118322; ENSMUSG00000033740.
DR Ensembl; ENSMUST00000150761; ENSMUSP00000120298; ENSMUSG00000033740.
DR Ensembl; ENSMUST00000151281; ENSMUSP00000122055; ENSMUSG00000033740.
DR Ensembl; ENSMUST00000163727; ENSMUSP00000131417; ENSMUSG00000033740.
DR GeneID; 240690; -.
DR KEGG; mmu:240690; -.
DR UCSC; uc007afw.1; mouse.
DR CTD; 9705; -.
DR MGI; MGI:2446700; St18.
DR VEuPathDB; HostDB:ENSMUSG00000033740; -.
DR eggNOG; KOG3803; Eukaryota.
DR GeneTree; ENSGT00940000159905; -.
DR HOGENOM; CLU_007226_0_0_1; -.
DR InParanoid; Q80TY4; -.
DR OMA; DECYLIS; -.
DR OrthoDB; 116799at2759; -.
DR PhylomeDB; Q80TY4; -.
DR TreeFam; TF317299; -.
DR BioGRID-ORCS; 240690; 0 hits in 71 CRISPR screens.
DR ChiTaRS; St18; mouse.
DR PRO; PR:Q80TY4; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q80TY4; protein.
DR Bgee; ENSMUSG00000033740; Expressed in cerebellum lobe and 120 other tissues.
DR ExpressionAtlas; Q80TY4; baseline and differential.
DR Genevisible; Q80TY4; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0032993; C:protein-DNA complex; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; ISO:MGI.
DR GO; GO:0070102; P:interleukin-6-mediated signaling pathway; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:2001269; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; ISO:MGI.
DR InterPro; IPR013681; Myelin_TF.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR Pfam; PF08474; MYT1; 1.
DR Pfam; PF01530; zf-C2HC; 6.
DR SUPFAM; SSF103637; SSF103637; 6.
DR PROSITE; PS51802; ZF_CCHHC; 6.
PE 2: Evidence at transcript level;
KW Coiled coil; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Repressor; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..1045
FT /note="Suppression of tumorigenicity 18 protein"
FT /id="PRO_0000234031"
FT ZN_FING 357..400
FT /note="CCHHC-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT ZN_FING 401..444
FT /note="CCHHC-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT ZN_FING 713..756
FT /note="CCHHC-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT ZN_FING 757..800
FT /note="CCHHC-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT ZN_FING 805..848
FT /note="CCHHC-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT ZN_FING 858..901
FT /note="CCHHC-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT REGION 38..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 918..987
FT /evidence="ECO:0000255"
FT COMPBIAS 65..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 366
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 371
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 384
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 390
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 410
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 415
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 428
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 434
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 722
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 727
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 740
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 746
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 766
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 771
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 784
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 790
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 814
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 819
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 832
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 838
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 867
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 872
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 885
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT BINDING 891
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01143"
FT CONFLICT 198
FT /note="S -> R (in Ref. 3; BAE24709)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="D -> N (in Ref. 3; BAE27844/BAE28057)"
FT /evidence="ECO:0000305"
FT CONFLICT 493
FT /note="E -> D (in Ref. 3; BAE23351)"
FT /evidence="ECO:0000305"
FT CONFLICT 736
FT /note="N -> D (in Ref. 3; BAE23351)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1045 AA; 114750 MW; B18FE57081BB0CFA CRC64;
MDAEVEDKTL HTLSKGTEVP MDSLIPELRV PYDCSMAKKR RAEEQASGVP INKRKSLLMK
PRHYSPDMGC KESPDNRNED DGLLETNDHA TADEIMVKSM DETLHLPAQD SSLQKKDQYT
CYPELMVKSL VHLGKFEESE SVQTTCENLN GSSIQSLKAE SDEAHEGSMV HSDNGRDKVH
HSQPPFCSSG DSESDSDSAE NGWGNGSNSS EDTDTHKGPK HKLTYNRKDL LEVPEIKAED
DKFIPCENRC DSDTDGRDPQ NSHMEPLVVK AQPSFPEVEE GESLATVTEE PAEVEKAKGN
LSLLEQAIAL QAERGSVFHH TYKELDRFFL DHLARERRQP RVTDANGRQI FTNKHSPRPE
RREAKCPIPG CDGTGHVTGL YPHHRSLSGC PHKVRVPLEI LAMHENVLKC PTPGCTGRGH
VNSNRNTHRS LSGCPIAAAE KLAMTQDKSQ LDSSQTGQCP EQAHRVNLVK QIEFNFRSHA
ITSPRASASK EQEKFGKVPF DYASFDAQVF GKRPLLQTGQ GQKAPPFPES KHFSNPVKFP
NGLPSAGAHT QSTVRASSYG HGQYSEDTHI AAAAAILNLS TRCREATDIL SNKPQSLRAK
GAEIEVDENG TLDLSMKKNR IHDKSIPPTS SPTTITTPSS SPFNASSLLV NAAFYQALSD
QEGWNVPINY SKSHGKTEEE KEKDPVNFLE NLEEKKFAGE ASIPSPKPKL HTRDLKKELI
TCPTPGCDGS GHVTGNYASH RSVSGCPLAD KTLKSLMAAN SQELKCPTPG CDGSGHVTGN
YASHRSLSGC PRARKGGIKM TPTKEEKEDS ELRCPVIGCD GQGHISGKYT SHRTASGCPL
AAKRQKENPL NGAPLSWKLN KQELPHCPLP GCNGLGHVNN VFVTHRSLSG CPLNAQAIKK
VKVSEELMTI KLKATGGIDG DEEIRHLDEE IKELNESNLK IEADMMKLQT QITSMESNLK
TIEEENKLIE QSNESLLKEL AGLSQALISS LADIQLPQMG PINEQNFEAY VNTLTDMYSN
LEQDYSPECK ALLESIKQAV KGIHV
