ID   ST20_HUMAN              Reviewed;          79 AA.
AC   Q9HBF5;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Suppressor of tumorigenicity 20 protein;
DE   AltName: Full=Human cervical cancer suppressor gene 1 protein;
DE            Short=HCCS-1;
GN   Name=ST20; Synonyms=HCCS1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-57, FUNCTION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=11857354; DOI=10.1002/ijc.10124;
RA   Kim T.E., Kim Y.W., Hwang S.Y., Shin S.M., Shin J.W., Lee Y.H., Shin S.Y.,
RA   Han K.T., Lee J.M., Namkoong S.E., Kim J.W.;
RT   "Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and
RT   induces apoptosis in cervical cancer.";
RL   Int. J. Cancer 97:780-786(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
CC   -!- FUNCTION: May act as a tumor suppressor. Promotes apoptosis of cancer
CC       cells. {ECO:0000269|PubMed:11857354}.
CC   -!- TISSUE SPECIFICITY: Expressed in leukocytes, lung, spleen, liver,
CC       heart, kidney, muscle and uterine cervix. Down-regulated in cervical
CC       cancer. {ECO:0000269|PubMed:11857354}.
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DR   EMBL; AF249277; AAG17280.1; -; mRNA.
DR   EMBL; AC015871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001094349.1; NM_001100879.1.
DR   RefSeq; NP_001094350.1; NM_001100880.2.
DR   RefSeq; NP_001186686.1; NM_001199757.1.
DR   AlphaFoldDB; Q9HBF5; -.
DR   BioGRID; 134590; 2.
DR   STRING; 9606.ENSP00000453502; -.
DR   iPTMnet; Q9HBF5; -.
DR   PhosphoSitePlus; Q9HBF5; -.
DR   BioMuta; ST20; -.
DR   MassIVE; Q9HBF5; -.
DR   PaxDb; Q9HBF5; -.
DR   PeptideAtlas; Q9HBF5; -.
DR   PRIDE; Q9HBF5; -.
DR   Ensembl; ENST00000478497.5; ENSP00000453502.1; ENSG00000180953.11.
DR   Ensembl; ENST00000485386.1; ENSP00000453693.1; ENSG00000180953.11.
DR   Ensembl; ENST00000562759.1; ENSP00000457965.1; ENSG00000180953.11.
DR   UCSC; uc002bez.5; human.
DR   GeneCards; ST20; -.
DR   HGNC; HGNC:33520; ST20.
DR   HPA; ENSG00000180953; Low tissue specificity.
DR   neXtProt; NX_Q9HBF5; -.
DR   OpenTargets; ENSG00000180953; -.
DR   PharmGKB; PA162404859; -.
DR   VEuPathDB; HostDB:ENSG00000180953; -.
DR   eggNOG; KOG4728; Eukaryota.
DR   GeneTree; ENSGT00940000165862; -.
DR   HOGENOM; CLU_2605354_0_0_1; -.
DR   InParanoid; Q9HBF5; -.
DR   OMA; EITGKIC; -.
DR   OrthoDB; 1561140at2759; -.
DR   PhylomeDB; Q9HBF5; -.
DR   TreeFam; TF341118; -.
DR   PathwayCommons; Q9HBF5; -.
DR   SignaLink; Q9HBF5; -.
DR   BioGRID-ORCS; 400410; 154 hits in 993 CRISPR screens.
DR   GenomeRNAi; 400410; -.
DR   Pharos; Q9HBF5; Tbio.
DR   PRO; PR:Q9HBF5; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q9HBF5; protein.
DR   Bgee; ENSG00000180953; Expressed in blood and 144 other tissues.
DR   Genevisible; Q9HBF5; HS.
DR   GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IDA:UniProtKB.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
DR   GO; GO:0097190; P:apoptotic signaling pathway; IDA:UniProtKB.
DR   GO; GO:0071494; P:cellular response to UV-C; IMP:UniProtKB.
DR   GO; GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
DR   GO; GO:1902512; P:positive regulation of apoptotic DNA fragmentation; IDA:UniProtKB.
PE   2: Evidence at transcript level;
KW   Reference proteome; Tumor suppressor.
FT   CHAIN           1..79
FT                   /note="Suppressor of tumorigenicity 20 protein"
FT                   /id="PRO_0000341245"
FT   VARIANT         57
FT                   /note="P -> L (in dbSNP:rs7257)"
FT                   /evidence="ECO:0000269|PubMed:11857354"
FT                   /id="VAR_044034"
SQ   SEQUENCE   79 AA;  9024 MW;  2B623BB954228E00 CRC64;
     MARSRLTATS VSQVQENGFV KKLEPKSGWM TFLEVTGKIC EMLFCPEAIL LTRKDTPYCE
     TGLIFLTLTK TIANTYFYF