ST3L3_HUMAN
ID ST3L3_HUMAN Reviewed; 134 AA.
AC P0CL85; A6NMT8; A8K0A1; Q32NE4; Q6NXR2; Q7L5M5; Q7Z5K6;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=STAG3-like protein 3;
DE AltName: Full=Stromal antigen 3-like protein 3;
GN Name=STAG3L3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RA Xu Z.Y., Xu M., Yin L.L., Lu L., Li J.M., Zhou J.M., Sha J.H.;
RT "An ARM-repeat superfamily protein acts in spermatogenesis.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Mammary gland, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P0CL85-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0CL85-2; Sequence=VSP_041016;
CC -!- SIMILARITY: Belongs to the SCC3 family. {ECO:0000305}.
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DR EMBL; AY313779; AAP81010.1; -; mRNA.
DR EMBL; AC005488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066937; AAH66937.1; -; mRNA.
DR AlphaFoldDB; P0CL85; -.
DR SMR; P0CL85; -.
DR iPTMnet; P0CL85; -.
DR PhosphoSitePlus; P0CL85; -.
DR BioMuta; HGNC:33845; -.
DR DMDM; 332321727; -.
DR MassIVE; P0CL85; -.
DR PeptideAtlas; P0CL85; -.
DR PRIDE; P0CL85; -.
DR ProteomicsDB; 52511; -. [P0CL85-1]
DR ProteomicsDB; 52512; -. [P0CL85-2]
DR GeneCards; STAG3L3; -.
DR HGNC; HGNC:33845; STAG3L3.
DR neXtProt; NX_P0CL85; -.
DR InParanoid; P0CL85; -.
DR PathwayCommons; P0CL85; -.
DR Pharos; P0CL85; Tdark.
DR PRO; PR:P0CL85; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0CL85; protein.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0008278; C:cohesin complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0007062; P:sister chromatid cohesion; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039662; Cohesin_Scc3/SA.
DR InterPro; IPR020839; SCD.
DR PANTHER; PTHR11199; PTHR11199; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51425; SCD; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..134
FT /note="STAG3-like protein 3"
FT /id="PRO_0000408000"
FT DOMAIN 10..95
FT /note="SCD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00750"
FT VAR_SEQ 117..134
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_041016"
FT CONFLICT 87
FT /note="C -> R (in Ref. 1; AAP81010 and 3; AAH66937)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 134 AA; 15609 MW; 6A7148BD316B9B72 CRC64;
MIFSMLRKLP KVTCRDVLPE IRAICIEEIG CWMQSYSTSF LTDSYLKYIG WTLHDKHREV
RVKCVKALKG LYGNRDLTAR LELFTGCFKD WMVSMIMDRE YSVAVEAVRL LILILKNMEG
VLMDVDCESV YPIV
