ST4A1_HUMAN
ID ST4A1_HUMAN Reviewed; 284 AA.
AC Q9BR01; B2R7N3; O43728;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Sulfotransferase 4A1;
DE Short=ST4A1;
DE EC=2.8.2.-;
DE AltName: Full=Brain sulfotransferase-like protein;
DE Short=hBR-STL;
DE Short=hBR-STL-1;
DE AltName: Full=Nervous system sulfotransferase;
DE Short=NST;
GN Name=SULT4A1; Synonyms=SULTX3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC TISSUE=Brain;
RX PubMed=10698717; DOI=10.1042/bj3460857;
RA Falany C.N., Xie X., Wang J., Ferrer J., Falany J.L.;
RT "Molecular cloning and expression of novel sulphotransferase-like cDNAs
RT from human and rat brain.";
RL Biochem. J. 346:857-864(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC TISSUE=Brain;
RX PubMed=12039030; DOI=10.1016/s0378-1119(02)00431-6;
RA Sakakibara Y., Suiko M., Pai T.G., Nakayama T., Takami Y., Katafuchi J.,
RA Liu M.-C.;
RT "Highly conserved mouse and human brain sulfotransferases: molecular
RT cloning, expression, and functional characterization.";
RL Gene 285:39-47(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RC TISSUE=Brain;
RA Martin S.C., Farb D.H.;
RT "Molecular identification of a human nervous system cytoplasmic
RT sulfotransferase, NST.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RC TISSUE=Brain;
RA Walther S.E., Raftogianis R.B.;
RT "Molecular and physical characterization of human SULT4A1, representing a
RT novel cytosolic sulfotransferase 1 family.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=12529303; DOI=10.1101/gr.695703;
RA Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S.,
RA Bye J.M., Beare D.M., Dunham I.;
RT "Reevaluating human gene annotation: a second-generation analysis of
RT chromosome 22.";
RL Genome Res. 13:27-36(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Fetal brain, Hippocampus, and Hypothalamus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS), FUNCTION, AND CHARACTERIZATION.
RX PubMed=17425406; DOI=10.1371/journal.pbio.0050097;
RA Allali-Hassani A., Pan P.W., Dombrovski L., Najmanovich R., Tempel W.,
RA Dong A., Loppnau P., Martin F., Thornton J., Edwards A.M., Bochkarev A.,
RA Plotnikov A.N., Vedadi M., Arrowsmith C.H.;
RT "Structural and chemical profiling of the human cytosolic
RT sulfotransferases.";
RL PLoS Biol. 5:E97-E97(2007).
CC -!- FUNCTION: Atypical sulfotransferase family member with very low
CC affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low
CC catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-
CC nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in
CC the metabolism of drugs and neurotransmitters in the CNS.
CC {ECO:0000269|PubMed:17425406}.
CC -!- INTERACTION:
CC Q9BR01; Q9UPT6: MAPK8IP3; NbExp=3; IntAct=EBI-6690555, EBI-717887;
CC Q9BR01; Q13526: PIN1; NbExp=4; IntAct=EBI-6690555, EBI-714158;
CC Q9BR01; Q9NUX5: POT1; NbExp=2; IntAct=EBI-6690555, EBI-752420;
CC Q9BR01; Q9BR01: SULT4A1; NbExp=6; IntAct=EBI-6690555, EBI-6690555;
CC Q9BR01; P22735: TGM1; NbExp=3; IntAct=EBI-6690555, EBI-2562368;
CC Q9BR01-2; Q92870-2: APBB2; NbExp=3; IntAct=EBI-25831443, EBI-21535880;
CC Q9BR01-2; Q9UBB4: ATXN10; NbExp=3; IntAct=EBI-25831443, EBI-702390;
CC Q9BR01-2; P14136: GFAP; NbExp=3; IntAct=EBI-25831443, EBI-744302;
CC Q9BR01-2; P42858: HTT; NbExp=15; IntAct=EBI-25831443, EBI-466029;
CC Q9BR01-2; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-25831443, EBI-1055254;
CC Q9BR01-2; P19404: NDUFV2; NbExp=3; IntAct=EBI-25831443, EBI-713665;
CC Q9BR01-2; P29474: NOS3; NbExp=3; IntAct=EBI-25831443, EBI-1391623;
CC Q9BR01-2; D3DTS7: PMP22; NbExp=3; IntAct=EBI-25831443, EBI-25882629;
CC Q9BR01-2; P37840: SNCA; NbExp=3; IntAct=EBI-25831443, EBI-985879;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BR01-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BR01-2; Sequence=VSP_006304;
CC -!- TISSUE SPECIFICITY: Highly expressed in the cerebral cortex and frontal
CC lobe, slightly less in the cerebellum, occipital and temporal lobes,
CC relatively low in the medulla and putamen, and lowest in the spinal
CC cord. No expression detected in the pancreas (PubMed:10698717). Highly
CC expressed in fetal brain and occipital lobe, slightly less in the whole
CC brain, frontal lobe, hippocampus, and lung, very low expression in
CC cerebellum, medulla oblongata, temporal lobe, testis, kidney and
CC appendix (PubMed:12039030). {ECO:0000269|PubMed:10698717,
CC ECO:0000269|PubMed:12039030}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. {ECO:0000305}.
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DR EMBL; AF188698; AAF61197.1; -; mRNA.
DR EMBL; AF115311; AAF21970.1; -; mRNA.
DR EMBL; AF176342; AAK64595.1; -; mRNA.
DR EMBL; AF251263; AAF98152.1; -; mRNA.
DR EMBL; AL590119; CAC34872.1; -; mRNA.
DR EMBL; CR456588; CAG30474.1; -; mRNA.
DR EMBL; AK313048; BAG35880.1; -; mRNA.
DR EMBL; Z97055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471138; EAW73320.1; -; Genomic_DNA.
DR EMBL; BC022459; AAH22459.1; -; mRNA.
DR EMBL; BC028171; AAH28171.1; -; mRNA.
DR EMBL; BC030665; AAH30665.1; -; mRNA.
DR CCDS; CCDS14051.1; -. [Q9BR01-1]
DR RefSeq; NP_055166.1; NM_014351.3. [Q9BR01-1]
DR PDB; 1ZD1; X-ray; 2.24 A; A/B=1-284.
DR PDBsum; 1ZD1; -.
DR AlphaFoldDB; Q9BR01; -.
DR SMR; Q9BR01; -.
DR BioGRID; 117358; 21.
DR IntAct; Q9BR01; 19.
DR MINT; Q9BR01; -.
DR STRING; 9606.ENSP00000332565; -.
DR ChEMBL; CHEMBL1743298; -.
DR DrugBank; DB12471; Ibrexafungerp.
DR DrugBank; DB00968; Methyldopa.
DR DrugBank; DB00960; Pindolol.
DR DrugBank; DB00871; Terbutaline.
DR iPTMnet; Q9BR01; -.
DR PhosphoSitePlus; Q9BR01; -.
DR BioMuta; SULT4A1; -.
DR DMDM; 22096149; -.
DR MassIVE; Q9BR01; -.
DR PaxDb; Q9BR01; -.
DR PeptideAtlas; Q9BR01; -.
DR PRIDE; Q9BR01; -.
DR ProteomicsDB; 78733; -. [Q9BR01-1]
DR ProteomicsDB; 78734; -. [Q9BR01-2]
DR Antibodypedia; 304; 172 antibodies from 26 providers.
DR DNASU; 25830; -.
DR Ensembl; ENST00000330884.9; ENSP00000332565.4; ENSG00000130540.14. [Q9BR01-1]
DR Ensembl; ENST00000422525.1; ENSP00000388285.1; ENSG00000130540.14. [Q9BR01-2]
DR GeneID; 25830; -.
DR KEGG; hsa:25830; -.
DR MANE-Select; ENST00000330884.9; ENSP00000332565.4; NM_014351.4; NP_055166.1.
DR UCSC; uc003bee.2; human. [Q9BR01-1]
DR CTD; 25830; -.
DR DisGeNET; 25830; -.
DR GeneCards; SULT4A1; -.
DR HGNC; HGNC:14903; SULT4A1.
DR HPA; ENSG00000130540; Tissue enriched (brain).
DR MIM; 608359; gene.
DR neXtProt; NX_Q9BR01; -.
DR OpenTargets; ENSG00000130540; -.
DR PharmGKB; PA412; -.
DR VEuPathDB; HostDB:ENSG00000130540; -.
DR eggNOG; KOG1584; Eukaryota.
DR GeneTree; ENSGT00940000158662; -.
DR HOGENOM; CLU_027239_1_1_1; -.
DR InParanoid; Q9BR01; -.
DR OMA; MVESCHQ; -.
DR OrthoDB; 780670at2759; -.
DR PhylomeDB; Q9BR01; -.
DR TreeFam; TF321745; -.
DR BRENDA; 2.8.2.1; 2681.
DR PathwayCommons; Q9BR01; -.
DR Reactome; R-HSA-156584; Cytosolic sulfonation of small molecules.
DR SignaLink; Q9BR01; -.
DR SIGNOR; Q9BR01; -.
DR BioGRID-ORCS; 25830; 8 hits in 1067 CRISPR screens.
DR EvolutionaryTrace; Q9BR01; -.
DR GeneWiki; SULT4A1; -.
DR GenomeRNAi; 25830; -.
DR Pharos; Q9BR01; Tbio.
DR PRO; PR:Q9BR01; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BR01; protein.
DR Bgee; ENSG00000130540; Expressed in right frontal lobe and 138 other tissues.
DR ExpressionAtlas; Q9BR01; baseline and differential.
DR Genevisible; Q9BR01; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR GO; GO:0008146; F:sulfotransferase activity; IBA:GO_Central.
DR GO; GO:0140059; P:dendrite arborization; IEA:Ensembl.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0051923; P:sulfation; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Lipid metabolism;
KW Phosphoprotein; Reference proteome; Steroid metabolism; Transferase.
FT CHAIN 1..284
FT /note="Sulfotransferase 4A1"
FT /id="PRO_0000085167"
FT MOD_RES 8
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P63047"
FT MOD_RES 11
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P63047"
FT MOD_RES 205
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT VAR_SEQ 248..284
FT /note="GRVGLWKDIFTVSMNEKFDLVYKQKMGKCDLTFDFYL -> AHCVFARKIFL
FT SW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12529303,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_006304"
FT CONFLICT 55..56
FT /note="KS -> P (in Ref. 10; AAH30665)"
FT /evidence="ECO:0000305"
FT CONFLICT 239
FT /note="N -> S (in Ref. 10; AAH22459)"
FT /evidence="ECO:0000305"
FT HELIX 15..17
FT /evidence="ECO:0007829|PDB:1ZD1"
FT STRAND 18..22
FT /evidence="ECO:0007829|PDB:1ZD1"
FT STRAND 25..27
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 29..31
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 35..39
FT /evidence="ECO:0007829|PDB:1ZD1"
FT STRAND 48..52
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 59..68
FT /evidence="ECO:0007829|PDB:1ZD1"
FT STRAND 91..94
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 96..101
FT /evidence="ECO:0007829|PDB:1ZD1"
FT STRAND 107..110
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 114..116
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 119..122
FT /evidence="ECO:0007829|PDB:1ZD1"
FT STRAND 126..132
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 135..144
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 158..166
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 175..183
FT /evidence="ECO:0007829|PDB:1ZD1"
FT TURN 184..187
FT /evidence="ECO:0007829|PDB:1ZD1"
FT STRAND 191..195
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 198..201
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 203..213
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 220..235
FT /evidence="ECO:0007829|PDB:1ZD1"
FT STRAND 242..246
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 252..255
FT /evidence="ECO:0007829|PDB:1ZD1"
FT HELIX 259..273
FT /evidence="ECO:0007829|PDB:1ZD1"
SQ SEQUENCE 284 AA; 33085 MW; A6EA6844B66C400B CRC64;
MAESEAETPS TPGEFESKYF EFHGVRLPPF CRGKMEEIAN FPVRPSDVWI VTYPKSGTSL
LQEVVYLVSQ GADPDEIGLM NIDEQLPVLE YPQPGLDIIK ELTSPRLIKS HLPYRFLPSD
LHNGDSKVIY MARNPKDLVV SYYQFHRSLR TMSYRGTFQE FCRRFMNDKL GYGSWFEHVQ
EFWEHRMDSN VLFLKYEDMH RDLVTMVEQL ARFLGVSCDK AQLEALTEHC HQLVDQCCNA
EALPVGRGRV GLWKDIFTVS MNEKFDLVYK QKMGKCDLTF DFYL
