ST65G_MOUSE
ID ST65G_MOUSE Reviewed; 412 AA.
AC Q9CZV5;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=STAGA complex 65 subunit gamma;
DE AltName: Full=SPTF-associated factor 65 gamma;
DE Short=STAF65gamma;
DE AltName: Full=Suppressor of Ty 7-like;
GN Name=Supt7l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-332, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the STAGA transcription coactivator-HAT complex,
CC at least composed of SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L,
CC TAD1L, TAF10, TAF12 and TAF9. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- PTM: Sumoylated. {ECO:0000250}.
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DR EMBL; AK012134; BAB28053.1; -; mRNA.
DR EMBL; BC031447; AAH31447.1; -; mRNA.
DR CCDS; CCDS19186.1; -.
DR RefSeq; NP_082426.1; NM_028150.2.
DR AlphaFoldDB; Q9CZV5; -.
DR SMR; Q9CZV5; -.
DR ComplexPortal; CPX-6803; SAGA complex, KAT2B variant.
DR ComplexPortal; CPX-920; SAGA complex, KAT2A variant.
DR STRING; 10090.ENSMUSP00000067337; -.
DR iPTMnet; Q9CZV5; -.
DR PhosphoSitePlus; Q9CZV5; -.
DR EPD; Q9CZV5; -.
DR jPOST; Q9CZV5; -.
DR MaxQB; Q9CZV5; -.
DR PaxDb; Q9CZV5; -.
DR PeptideAtlas; Q9CZV5; -.
DR PRIDE; Q9CZV5; -.
DR ProteomicsDB; 254576; -.
DR Antibodypedia; 50579; 99 antibodies from 18 providers.
DR DNASU; 72195; -.
DR Ensembl; ENSMUST00000065388; ENSMUSP00000067337; ENSMUSG00000053134.
DR Ensembl; ENSMUST00000201769; ENSMUSP00000144065; ENSMUSG00000053134.
DR GeneID; 72195; -.
DR KEGG; mmu:72195; -.
DR UCSC; uc008wyj.2; mouse.
DR CTD; 9913; -.
DR MGI; MGI:1919445; Supt7l.
DR VEuPathDB; HostDB:ENSMUSG00000053134; -.
DR eggNOG; ENOG502QQTJ; Eukaryota.
DR GeneTree; ENSGT00390000005572; -.
DR InParanoid; Q9CZV5; -.
DR OMA; YEKIVNP; -.
DR OrthoDB; 1243197at2759; -.
DR PhylomeDB; Q9CZV5; -.
DR TreeFam; TF328615; -.
DR BioGRID-ORCS; 72195; 5 hits in 75 CRISPR screens.
DR ChiTaRS; Supt7l; mouse.
DR PRO; PR:Q9CZV5; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CZV5; protein.
DR Bgee; ENSMUSG00000053134; Expressed in rostral migratory stream and 190 other tissues.
DR ExpressionAtlas; Q9CZV5; baseline and differential.
DR Genevisible; Q9CZV5; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0000124; C:SAGA complex; ISO:MGI.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0003713; F:transcription coactivator activity; ISO:MGI.
DR GO; GO:0043966; P:histone H3 acetylation; ISO:MGI.
DR GO; GO:0051457; P:maintenance of protein location in nucleus; ISO:MGI.
DR GO; GO:0035521; P:monoubiquitinated histone deubiquitination; ISO:MGI.
DR GO; GO:0035522; P:monoubiquitinated histone H2A deubiquitination; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IC:ComplexPortal.
DR GO; GO:0006282; P:regulation of DNA repair; IC:ComplexPortal.
DR GO; GO:0043484; P:regulation of RNA splicing; IC:ComplexPortal.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR006565; BTP.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR039460; SUPT7L.
DR PANTHER; PTHR28598; PTHR28598; 1.
DR Pfam; PF07524; Bromo_TP; 1.
DR SMART; SM00576; BTP; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..412
FT /note="STAGA complex 65 subunit gamma"
FT /id="PRO_0000072234"
FT REGION 81..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 106
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94864"
FT MOD_RES 321
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 332
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CROSSLNK 269
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O94864"
SQ SEQUENCE 412 AA; 45971 MW; B7BF1525BB44F6D5 CRC64;
MLRYWGEIPI PSGQTNRSSF DLLPREFRLV EVHDPPLHQP SANKPKPPTM LDIPSEPCSL
TIHTIQLIQH NRRLRSLIAT AQTQSQQQTE GVKAEESEPL PSCPGSPPLP DDLQPLDCKN
PNAPFQIRHS DPESDFYRGK GEPVTELSWH SCRQLLYQAV ATILAHTGFE CANESVLETL
TDVAHEYCLK FTKLLRFAVD REALLGQTPF PDVMEQVFHE VGIGSVLSLQ KFWQHRIKDY
HTYMLQISKQ LSEEYERIVN PEKATEDTKP VKIKEEPVSD ITFPVSEELE ADLASGDQSL
PIGVLGAQSE RFPSNLEVEA SPQAPSAEVN ASPLWNLAHV KMEPQESEEG NVSAHGVLGS
DVFEEPMSGM SEAGLPQSPD DSDSSYGSHS TDSLMGSSPV FNQRCRKRMR KI
