ID   ST6B1_GORGO             Reviewed;         303 AA.
AC   Q6WG17;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Sulfotransferase 6B1;
DE            Short=ST6B1;
DE   AltName: Full=Thyroxine sulfotransferase;
DE            EC=2.8.2.n2;
GN   Name=SULT6B1;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14676822; DOI=10.1038/sj.tpj.6500223;
RA   Freimuth R.R., Wiepert M., Chute C.G., Wieben E.D., Weinshilboum R.M.;
RT   "Human cytosolic sulfotransferase database mining: identification of seven
RT   novel genes and pseudogenes.";
RL   Pharmacogenomics J. 4:54-65(2004).
CC   -!- FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate
CC       (PAPS) as sulfonate donor to catalyze the sulfate conjugation of
CC       thyroxine. Involved in the metabolism of thyroxine (By similarity).
CC       {ECO:0000250|UniProtKB:P0CC03}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-
CC         bisphosphate + H(+) + thyroxine sulfate; Xref=Rhea:RHEA:26422,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343,
CC         ChEBI:CHEBI:58910, ChEBI:CHEBI:305790; EC=2.8.2.n2;
CC         Evidence={ECO:0000250|UniProtKB:P0CC03};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P0CC03}.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAQ23222.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY289789; AAQ23222.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AY289783; AAQ23222.1; JOINED; Genomic_DNA.
DR   EMBL; AY289784; AAQ23222.1; JOINED; Genomic_DNA.
DR   EMBL; AY289785; AAQ23222.1; JOINED; Genomic_DNA.
DR   EMBL; AY289786; AAQ23222.1; JOINED; Genomic_DNA.
DR   EMBL; AY289787; AAQ23222.1; JOINED; Genomic_DNA.
DR   EMBL; AY289788; AAQ23222.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q6WG17; -.
DR   SMR; Q6WG17; -.
DR   STRING; 9593.ENSGGOP00000008043; -.
DR   eggNOG; KOG1584; Eukaryota.
DR   InParanoid; Q6WG17; -.
DR   Proteomes; UP000001519; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0008146; F:sulfotransferase activity; IBA:GO_Central.
DR   GO; GO:0051923; P:sulfation; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Transferase.
FT   CHAIN           1..303
FT                   /note="Sulfotransferase 6B1"
FT                   /id="PRO_0000085170"
FT   ACT_SITE        118
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P49891"
FT   BINDING         65..70
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250|UniProtKB:P49891"
FT   BINDING         140
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250|UniProtKB:P49891"
FT   BINDING         148
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250|UniProtKB:P49891"
FT   BINDING         203
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250|UniProtKB:P49891"
FT   BINDING         237..242
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250|UniProtKB:P49891"
FT   BINDING         259..261
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000250|UniProtKB:P49891"
SQ   SEQUENCE   303 AA;  34809 MW;  338D51A73727A0EE CRC64;
     MADKSKFTEY IDKALEKSKE TALSHLFFTY QGIAYPITMC TSETFQALDT FEARHDDIVL
     ASYPKCGSNW ILHIVSELIY AVSKKKYKYP EFPVLECGDS EKYQRMKGFP SPRILATHLH
     YDKLPGSIFK NKAKILVIFR NPTDTAVSFF HFHNDVPDIP SYGSWDELFR QFMKGQVSWG
     SYFDFAINWN KHLDGDNVKF ILYEDLKENL AAGIKQIPEF LGFFLTGEQI QTISVQSTFQ
     AMRAKSQDTH GAVGPFLFRK GEVGDWKNLF SEIQNQEMDE KFKECLAGTS LGAKLKYESY
     CQG