ST7L_HUMAN
ID ST7L_HUMAN Reviewed; 575 AA.
AC Q8TDW4; A8K4S7; Q49AH6; Q5TEI4; Q5U5K6; Q6N067; Q7Z2Z0; Q7Z3C2; Q8N7P8;
AC Q8TDW1; Q8TDW2; Q8TDW3; Q9NXF3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Suppressor of tumorigenicity 7 protein-like;
DE AltName: Full=ST7-related protein;
GN Name=ST7L; Synonyms=ST7R;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 5).
RX PubMed=12012006;
RA Katoh M.;
RT "Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human
RT chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on
RT human chromosome 7q31.";
RL Int. J. Oncol. 20:1247-1253(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANT
RP GLN-451.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 225-575 (ISOFORM 2).
RC TISSUE=Rectum tumor, Testis, and Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 7 AND 8).
RC TISSUE=Brain, Duodenum, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=1;
CC IsoId=Q8TDW4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TDW4-2; Sequence=VSP_034131;
CC Name=3;
CC IsoId=Q8TDW4-3; Sequence=VSP_034129;
CC Name=4;
CC IsoId=Q8TDW4-4; Sequence=VSP_034127;
CC Name=5;
CC IsoId=Q8TDW4-5; Sequence=VSP_034134, VSP_034135;
CC Name=6;
CC IsoId=Q8TDW4-6; Sequence=VSP_034129, VSP_034134, VSP_034135;
CC Name=7;
CC IsoId=Q8TDW4-7; Sequence=VSP_034133, VSP_034136;
CC Name=8;
CC IsoId=Q8TDW4-8; Sequence=VSP_034128, VSP_034130, VSP_034132;
CC -!- SIMILARITY: Belongs to the ST7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91060.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAE45803.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB081317; BAB88871.1; -; mRNA.
DR EMBL; AB081318; BAB88872.1; -; mRNA.
DR EMBL; AB081319; BAB88873.1; -; mRNA.
DR EMBL; AB081320; BAB88874.1; -; mRNA.
DR EMBL; AK000291; BAA91060.1; ALT_INIT; mRNA.
DR EMBL; AK097837; BAC05180.1; -; mRNA.
DR EMBL; AK291042; BAF83731.1; -; mRNA.
DR EMBL; BX537988; CAD97948.1; -; mRNA.
DR EMBL; BX538338; CAD98103.1; -; mRNA.
DR EMBL; BX640667; CAE45803.1; ALT_INIT; mRNA.
DR EMBL; AL109932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471122; EAW56520.1; -; Genomic_DNA.
DR EMBL; CH471122; EAW56522.1; -; Genomic_DNA.
DR EMBL; CH471122; EAW56523.1; -; Genomic_DNA.
DR EMBL; CH471122; EAW56524.1; -; Genomic_DNA.
DR EMBL; BC037830; AAH37830.1; -; mRNA.
DR EMBL; BC047392; AAH47392.1; -; mRNA.
DR EMBL; BC065501; AAH65501.1; -; mRNA.
DR CCDS; CCDS76189.1; -. [Q8TDW4-4]
DR CCDS; CCDS848.1; -. [Q8TDW4-1]
DR CCDS; CCDS849.1; -. [Q8TDW4-3]
DR CCDS; CCDS850.1; -. [Q8TDW4-2]
DR CCDS; CCDS852.1; -. [Q8TDW4-5]
DR RefSeq; NP_001295193.1; NM_001308264.1. [Q8TDW4-4]
DR RefSeq; NP_060214.2; NM_017744.4. [Q8TDW4-1]
DR RefSeq; NP_620055.1; NM_138727.3. [Q8TDW4-3]
DR RefSeq; NP_620056.1; NM_138728.2. [Q8TDW4-2]
DR RefSeq; NP_620057.1; NM_138729.3. [Q8TDW4-5]
DR AlphaFoldDB; Q8TDW4; -.
DR SMR; Q8TDW4; -.
DR BioGRID; 120227; 36.
DR IntAct; Q8TDW4; 19.
DR STRING; 9606.ENSP00000350734; -.
DR iPTMnet; Q8TDW4; -.
DR PhosphoSitePlus; Q8TDW4; -.
DR BioMuta; ST7L; -.
DR DMDM; 74751431; -.
DR jPOST; Q8TDW4; -.
DR MassIVE; Q8TDW4; -.
DR MaxQB; Q8TDW4; -.
DR PaxDb; Q8TDW4; -.
DR PeptideAtlas; Q8TDW4; -.
DR PRIDE; Q8TDW4; -.
DR ProteomicsDB; 74346; -. [Q8TDW4-1]
DR ProteomicsDB; 74347; -. [Q8TDW4-2]
DR ProteomicsDB; 74348; -. [Q8TDW4-3]
DR ProteomicsDB; 74349; -. [Q8TDW4-4]
DR ProteomicsDB; 74350; -. [Q8TDW4-5]
DR ProteomicsDB; 74351; -. [Q8TDW4-6]
DR ProteomicsDB; 74352; -. [Q8TDW4-7]
DR ProteomicsDB; 74353; -. [Q8TDW4-8]
DR Antibodypedia; 46941; 39 antibodies from 17 providers.
DR DNASU; 54879; -.
DR Ensembl; ENST00000343210.11; ENSP00000345312.7; ENSG00000007341.19. [Q8TDW4-5]
DR Ensembl; ENST00000358039.9; ENSP00000350734.4; ENSG00000007341.19. [Q8TDW4-1]
DR Ensembl; ENST00000360743.8; ENSP00000353972.4; ENSG00000007341.19. [Q8TDW4-2]
DR Ensembl; ENST00000361846.7; ENSP00000436499.1; ENSG00000007341.19. [Q8TDW4-7]
DR Ensembl; ENST00000369666.5; ENSP00000358680.1; ENSG00000007341.19. [Q8TDW4-6]
DR Ensembl; ENST00000369669.5; ENSP00000358683.1; ENSG00000007341.19. [Q8TDW4-4]
DR Ensembl; ENST00000490067.5; ENSP00000417140.1; ENSG00000007341.19. [Q8TDW4-3]
DR Ensembl; ENST00000490715.5; ENSP00000436544.1; ENSG00000007341.19. [Q8TDW4-7]
DR GeneID; 54879; -.
DR KEGG; hsa:54879; -.
DR MANE-Select; ENST00000358039.9; ENSP00000350734.4; NM_017744.5; NP_060214.2.
DR UCSC; uc001ecc.4; human. [Q8TDW4-1]
DR CTD; 54879; -.
DR DisGeNET; 54879; -.
DR GeneCards; ST7L; -.
DR HGNC; HGNC:18441; ST7L.
DR HPA; ENSG00000007341; Tissue enriched (testis).
DR MIM; 617640; gene.
DR neXtProt; NX_Q8TDW4; -.
DR OpenTargets; ENSG00000007341; -.
DR PharmGKB; PA38331; -.
DR VEuPathDB; HostDB:ENSG00000007341; -.
DR eggNOG; KOG3807; Eukaryota.
DR GeneTree; ENSGT00390000000873; -.
DR HOGENOM; CLU_035578_2_0_1; -.
DR InParanoid; Q8TDW4; -.
DR OMA; FAGKDIN; -.
DR OrthoDB; 540550at2759; -.
DR PhylomeDB; Q8TDW4; -.
DR TreeFam; TF314162; -.
DR PathwayCommons; Q8TDW4; -.
DR SignaLink; Q8TDW4; -.
DR BioGRID-ORCS; 54879; 6 hits in 1075 CRISPR screens.
DR ChiTaRS; ST7L; human.
DR GenomeRNAi; 54879; -.
DR Pharos; Q8TDW4; Tbio.
DR PRO; PR:Q8TDW4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TDW4; protein.
DR Bgee; ENSG00000007341; Expressed in sperm and 133 other tissues.
DR ExpressionAtlas; Q8TDW4; baseline and differential.
DR Genevisible; Q8TDW4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030308; P:negative regulation of cell growth; ISS:BHF-UCL.
DR CDD; cd11557; ST7; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR007311; ST7.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12745; PTHR12745; 1.
DR Pfam; PF04184; ST7; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..575
FT /note="Suppressor of tumorigenicity 7 protein-like"
FT /id="PRO_0000339227"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 125..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..183
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034127"
FT VAR_SEQ 1..122
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034128"
FT VAR_SEQ 69..85
FT /note="Missing (in isoform 3 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:12012006,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034129"
FT VAR_SEQ 416..503
FT /note="YLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTF
FT RMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSV -> VEIYPFSPQLNIKAVDNSA
FT ISKYPANIY (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034130"
FT VAR_SEQ 466..496
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12012006,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034131"
FT VAR_SEQ 504..575
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034132"
FT VAR_SEQ 545..568
FT /note="LGLWCPQPWASSGFEENTQDLKSE -> VGVKTQKENAD (in isoform
FT 7)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034133"
FT VAR_SEQ 545..566
FT /note="LGLWCPQPWASSGFEENTQDLK -> SMISRTCVDYL (in isoform 5
FT and isoform 6)"
FT /evidence="ECO:0000303|PubMed:12012006,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034134"
FT VAR_SEQ 567..575
FT /note="Missing (in isoform 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:12012006,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034135"
FT VAR_SEQ 569..575
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034136"
FT VARIANT 451
FT /note="R -> Q (in dbSNP:rs6658555)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_043934"
FT VARIANT 455
FT /note="A -> T (in dbSNP:rs3736764)"
FT /id="VAR_043935"
FT VARIANT 571
FT /note="G -> D (in dbSNP:rs12069022)"
FT /id="VAR_043936"
FT CONFLICT 204
FT /note="P -> H (in Ref. 6; AAH37830)"
FT /evidence="ECO:0000305"
FT CONFLICT 236
FT /note="A -> T (in Ref. 3; CAD98103)"
FT /evidence="ECO:0000305"
FT CONFLICT 274
FT /note="C -> Y (in Ref. 3; CAD97948)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="E -> V (in Ref. 3; CAD98103)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="R -> I (in Ref. 3; CAD97948)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 575 AA; 64779 MW; 26F30D175DD6E8A0 CRC64;
MADRGGVGEA AAVGASPASV PGLNPTLGWR ERLRAGLAGT GASLWFVAGL GLLYALRIPL
RLCENLAAVT VFLNSLTPKF YVALTGTSSL ISGLIFIFEW WYFHKHGTSF IEQVSVSHLQ
PLMGGTESSI SEPGSPSRNR ENETSRQNLS ECKVWRNPLN LFRGAEYRRY TWVTGKEPLT
YYDMNLSAQD HQTFFTCDTD FLRPSDTVMQ KAWRERNPPA RIKAAYQALE LNNDCATAYV
LLAEEEATTI VDAERLFKQA LKAGETIYRQ SQQCQHQSPQ HEAQLRRDTN VLVYIKRRLA
MCARKLGRIR EAVKIMRDLM KEFPPLTMLN IHENLLESLL ELQAYPDVQA VLAKYDDISL
PKSAAICYTA ALLKTRTVSE KFSPETASRR GLSTAEINAV EAIHRAVEFN PHVPKYLLEM
KSLILPPEHI LKRGDSEAIA YAFFHLQHWK RIEGALNLLQ CTWEGTFRMI PYPLEKGHLF
YPYPSCTETA DRELLPTFHH VSVYPKKELP LFIHFTAGFC SSTAMIAILT HQFPEIMGIF
AKAVLGLWCP QPWASSGFEE NTQDLKSEDL GLSSG
