ST7L_MOUSE
ID ST7L_MOUSE Reviewed; 559 AA.
AC Q8K4P7; Q3T9Y2; Q3UNR1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Suppressor of tumorigenicity 7 protein-like;
DE AltName: Full=ST7-related protein;
GN Name=St7l; Synonyms=St7r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=12060862;
RA Saitoh T., Katoh M.;
RT "Molecular cloning and characterization of mouse St7r (St7-like, St7l).";
RL Int. J. Mol. Med. 10:119-123(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8K4P7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K4P7-2; Sequence=VSP_034138;
CC Name=3;
CC IsoId=Q8K4P7-3; Sequence=VSP_034137;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:12060862}.
CC -!- SIMILARITY: Belongs to the ST7 family. {ECO:0000305}.
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DR EMBL; AB084518; BAB91408.1; -; mRNA.
DR EMBL; AK144075; BAE25686.1; -; mRNA.
DR EMBL; AK172102; BAE42827.1; -; mRNA.
DR EMBL; AK172218; BAE42888.1; -; mRNA.
DR EMBL; BC058781; AAH58781.1; -; mRNA.
DR EMBL; BC107394; AAI07395.1; -; mRNA.
DR EMBL; BC145950; AAI45951.1; -; mRNA.
DR CCDS; CCDS17705.1; -. [Q8K4P7-1]
DR CCDS; CCDS57250.1; -. [Q8K4P7-2]
DR CCDS; CCDS79994.1; -. [Q8K4P7-3]
DR RefSeq; NP_001240631.1; NM_001253702.1. [Q8K4P7-2]
DR RefSeq; NP_001240632.1; NM_001253703.1. [Q8K4P7-3]
DR RefSeq; NP_694731.1; NM_153091.3. [Q8K4P7-1]
DR AlphaFoldDB; Q8K4P7; -.
DR SMR; Q8K4P7; -.
DR STRING; 10090.ENSMUSP00000058455; -.
DR iPTMnet; Q8K4P7; -.
DR PhosphoSitePlus; Q8K4P7; -.
DR MaxQB; Q8K4P7; -.
DR PaxDb; Q8K4P7; -.
DR PeptideAtlas; Q8K4P7; -.
DR PRIDE; Q8K4P7; -.
DR ProteomicsDB; 257085; -. [Q8K4P7-1]
DR ProteomicsDB; 257086; -. [Q8K4P7-2]
DR ProteomicsDB; 257087; -. [Q8K4P7-3]
DR Antibodypedia; 46941; 39 antibodies from 17 providers.
DR DNASU; 229681; -.
DR Ensembl; ENSMUST00000059271; ENSMUSP00000058455; ENSMUSG00000045576. [Q8K4P7-1]
DR Ensembl; ENSMUST00000106769; ENSMUSP00000102380; ENSMUSG00000045576. [Q8K4P7-2]
DR Ensembl; ENSMUST00000200132; ENSMUSP00000143759; ENSMUSG00000045576. [Q8K4P7-3]
DR GeneID; 229681; -.
DR KEGG; mmu:229681; -.
DR UCSC; uc008qur.2; mouse. [Q8K4P7-1]
DR UCSC; uc008qus.2; mouse. [Q8K4P7-2]
DR UCSC; uc012cvm.2; mouse. [Q8K4P7-3]
DR CTD; 54879; -.
DR MGI; MGI:2386964; St7l.
DR VEuPathDB; HostDB:ENSMUSG00000045576; -.
DR eggNOG; KOG3807; Eukaryota.
DR GeneTree; ENSGT00390000000873; -.
DR InParanoid; Q8K4P7; -.
DR OMA; FAGKDIN; -.
DR PhylomeDB; Q8K4P7; -.
DR TreeFam; TF314162; -.
DR BioGRID-ORCS; 229681; 2 hits in 73 CRISPR screens.
DR ChiTaRS; St7l; mouse.
DR PRO; PR:Q8K4P7; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8K4P7; protein.
DR Bgee; ENSMUSG00000045576; Expressed in right kidney and 245 other tissues.
DR ExpressionAtlas; Q8K4P7; baseline and differential.
DR Genevisible; Q8K4P7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030308; P:negative regulation of cell growth; IDA:BHF-UCL.
DR CDD; cd11557; ST7; 1.
DR InterPro; IPR007311; ST7.
DR PANTHER; PTHR12745; PTHR12745; 1.
DR Pfam; PF04184; ST7; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..559
FT /note="Suppressor of tumorigenicity 7 protein-like"
FT /id="PRO_0000339228"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 212..290
FT /note="VMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQ
FT ALRAGEIIYRRSQQCQHQSPQHEAQLR -> G (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034137"
FT VAR_SEQ 420..451
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034138"
SQ SEQUENCE 559 AA; 63368 MW; 27065D795A9C304B CRC64;
MADGDYFAEA ARAVGCPHAP VPGLGLGPPL GWKERLKAGL ANSGSTLWFL AGLGLLYALR
VPLRLCDNVT AVTGFLSSLT PKFYVALTGT SSLISGLIFI FEWWYFHKHG TSFIEQVSIS
HLRPLMGGTE SSISEPGSPA NSRESETLRH HHLSECKVWR NPLNLFRGAE YRRYTWVTGK
EPLTYYDMNL SAQDHQTFFT CETDFLRPSD TVMQKAWRER NPPARIKAAY QALELNNDCA
TAYVLLAEEE ATTIVDAERL FKQALRAGEI IYRRSQQCQH QSPQHEAQLR RDTNVLVYIK
RRLAMCARKL GRIREAVKIM RDLMKEFPPL TMLNIHENLL ESLLELQAYA DVQAVLAKYD
DISLPKSAAI CYTAALLKTR TVSDKFSPET AFRKGLSTAE INAVEAIHRA VEFNPHVPKY
LLEMKSLILP PEHILKRGDS EAIAYAFFHL QHWKRIEGAL NLLQCTWEGT FRMIPYPLEK
GHLFYPYPSC TETADRELLP TFHHVSVYPK KELPFFIHFT AGLCSSTAML AFLTHQFPEV
MGVFAKAVSM ISRTCVEYL
