ID   ST7_BOVIN               Reviewed;         585 AA.
AC   A4D7R9; Q9BDI1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Suppressor of tumorigenicity 7 protein;
GN   Name=ST7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12917688; DOI=10.1038/nature01858;
RA   Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G.,
RA   Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C.,
RA   Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S.,
RA   Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R., Cutler D.J.,
RA   Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q.,
RA   Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N.,
RA   Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S.,
RA   Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E.,
RA   Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A.,
RA   Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E.,
RA   Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D.,
RA   Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B.,
RA   Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A.,
RA   Haussler D., Green P., Miller W., Green E.D.;
RT   "Comparative analyses of multi-species sequences from targeted genomic
RT   regions.";
RL   Nature 424:788-793(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 165-585 (ISOFORM 2).
RX   PubMed=11279520; DOI=10.1038/86891;
RA   Zenklusen J.C., Conti C.J., Green E.D.;
RT   "Mutational and functional analyses reveal that ST7 is a highly conserved
RT   tumor-suppressor gene on human chromosome 7q31.";
RL   Nat. Genet. 27:392-398(2001).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A4D7R9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A4D7R9-2; Sequence=VSP_034106, VSP_034107;
CC   -!- SIMILARITY: Belongs to the ST7 family. {ECO:0000305}.
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DR   EMBL; DP000008; AAR16260.1; -; Genomic_DNA.
DR   EMBL; AY007801; AAG24467.1; -; mRNA.
DR   RefSeq; XP_005205443.1; XM_005205386.3. [A4D7R9-1]
DR   AlphaFoldDB; A4D7R9; -.
DR   STRING; 9913.ENSBTAP00000049962; -.
DR   PaxDb; A4D7R9; -.
DR   Ensembl; ENSBTAT00000053015; ENSBTAP00000049962; ENSBTAG00000010756. [A4D7R9-1]
DR   GeneID; 280933; -.
DR   CTD; 7982; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010756; -.
DR   eggNOG; KOG3807; Eukaryota.
DR   GeneTree; ENSGT00390000000873; -.
DR   HOGENOM; CLU_035578_2_0_1; -.
DR   InParanoid; A4D7R9; -.
DR   OMA; LLPSWHE; -.
DR   OrthoDB; 540550at2759; -.
DR   TreeFam; TF314162; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000010756; Expressed in prostate gland and 103 other tissues.
DR   ExpressionAtlas; A4D7R9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd11557; ST7; 1.
DR   InterPro; IPR007311; ST7.
DR   PANTHER; PTHR12745; PTHR12745; 1.
DR   Pfam; PF04184; ST7; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..585
FT                   /note="Suppressor of tumorigenicity 7 protein"
FT                   /id="PRO_0000339192"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        512..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         386
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRC1"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         215..237
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11279520"
FT                   /id="VSP_034106"
FT   VAR_SEQ         547..585
FT                   /note="MIDIFCSAELRDWNCESIFMRVEDELEIPPAPQSQHFQN -> FLSTLFAPL
FT                   NFVMEKVESILPSSLWHQLTRI (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11279520"
FT                   /id="VSP_034107"
FT   CONFLICT        307
FT                   /note="R -> K (in Ref. 2; AAG24467)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        357..359
FT                   /note="KYD -> ERG (in Ref. 2; AAG24467)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   585 AA;  67119 MW;  7CFFA89057E40D47 CRC64;
     MAEAGTGFLE QLKSCIVWSW TYLWTVWFFI VLFLVYILRV PLKINDNLST VSMFLNTLTP
     KFYVALTGTS SLISGLILIF EWWYFRKYGT SFIEQVSVSH LRPLLGGVDN NSSNNSNSSN
     GDSDSNRQSV SECKVWRNPL NLFRGAEYNR YTWVTGREPL TYYDMNLSAQ DHQTFFTCDS
     DHLRPADAIM QKAWRERNPQ ARISAAHEAL EINEIRSRVE VPLIASSTIW EIKLLPKCAT
     AYILLAEEEA TTIAEAEKLF KQALKAGDGC YRRSQQLQHH GSQYEAQHRR DTNVLVYIKR
     RLAMCARRLG RTREAVKMMR DLMKEFPLLS MFNIHENLLE ALLELQAYAD VQAVLAKYDD
     ISLPKSATIC YTAALLKARA VSDKFSPEAA SRRGLSTAEM NAVEAIHRAV EFNPHVPKYL
     LEMKSLILPP EHILKRGDSE AIAYAFFHLA HWKRVEGALN LLHCTWEGTF RMIPYPLEKG
     HLFYPYPICT ETADRELLPS FHEVSVYPKK ELPFFILFTA GLCSFTAMLA LLTHQFPELM
     GVFAKAMIDI FCSAELRDWN CESIFMRVED ELEIPPAPQS QHFQN