ST7_DROME
ID ST7_DROME Reviewed; 537 AA.
AC Q9VPB1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein ST7 homolog;
GN ORFNames=CG3634;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ST7 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF51644.1; -; Genomic_DNA.
DR EMBL; AY071424; AAL49046.1; -; mRNA.
DR RefSeq; NP_001262124.1; NM_001275195.1.
DR RefSeq; NP_001262125.1; NM_001275196.1.
DR RefSeq; NP_649260.1; NM_141003.3.
DR AlphaFoldDB; Q9VPB1; -.
DR SMR; Q9VPB1; -.
DR IntAct; Q9VPB1; 1.
DR STRING; 7227.FBpp0077930; -.
DR PaxDb; Q9VPB1; -.
DR DNASU; 40301; -.
DR EnsemblMetazoa; FBtr0078272; FBpp0077930; FBgn0037026.
DR EnsemblMetazoa; FBtr0331528; FBpp0303918; FBgn0037026.
DR EnsemblMetazoa; FBtr0331529; FBpp0303919; FBgn0037026.
DR GeneID; 40301; -.
DR KEGG; dme:Dmel_CG3634; -.
DR UCSC; CG3634-RA; d. melanogaster.
DR FlyBase; FBgn0037026; CG3634.
DR VEuPathDB; VectorBase:FBgn0037026; -.
DR eggNOG; KOG3807; Eukaryota.
DR GeneTree; ENSGT00390000000873; -.
DR HOGENOM; CLU_035578_2_0_1; -.
DR InParanoid; Q9VPB1; -.
DR OMA; SSGTPEC; -.
DR OrthoDB; 540550at2759; -.
DR PhylomeDB; Q9VPB1; -.
DR BioGRID-ORCS; 40301; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG3634; fly.
DR GenomeRNAi; 40301; -.
DR PRO; PR:Q9VPB1; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0037026; Expressed in eye disc (Drosophila) and 21 other tissues.
DR ExpressionAtlas; Q9VPB1; baseline and differential.
DR Genevisible; Q9VPB1; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd11557; ST7; 1.
DR InterPro; IPR007311; ST7.
DR PANTHER; PTHR12745; PTHR12745; 1.
DR Pfam; PF04184; ST7; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..537
FT /note="Protein ST7 homolog"
FT /id="PRO_0000339223"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 61..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 60194 MW; AB85C13990AD458D CRC64;
MWDSSMFLST LTPKFYVALT GTSSLISGLI LIFEWWYFRK YGTSFIEQVS INHISPWING
SDGQSESSNG SGSSSSSGSS SSSNGGAGGG GSGGAGASGS GSATTSTGTQ MPECKVWRNP
LNLFRGAEYQ RFFWATSKEP LTYYDMNLSA QDHQTFFTCE GDARKEEYEI MQTAWRERNP
MQRIKSAHSA LEINAECAPA YILLAEEEAM TIMEAEKILK TALKVAEINY RKSQATQHQG
AIADGMHRRD TNVLIYIKRR LAMCARKLGK LKEAAKMFRD LTKEIPSIMS VLNIHENLIE
TLLEMQAYAD CHAILAKYDD ISLPKSATIC YTAALLKARA VADKFSPDIA SKRGLSQAEM
SAVEAIHRAV EFNPHVPKYL LETKRLILPP EHILKRGDSE ALAYAFFHLK HWKQVEGALN
LLHCTWEGTF RMLPYPLERG HLFYPYPTCT ECADRELLPA FHEVSVYPKK ELPFFILFTA
GLCSITALLA LATHQYPEPM GHLAQTVLTW ISYPFQLLKE RIEAFWPCNL LQQLSRV
