ST7_HUMAN
ID ST7_HUMAN Reviewed; 585 AA.
AC Q9NRC1; A4D0V2; Q5CZ72; Q7LE31; Q7LE32; Q8NA32; Q8NEJ8; Q8TDI9; Q9BWX3;
AC Q9BWX4; Q9NRC2; Q9NXZ7;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Suppressor of tumorigenicity 7 protein;
DE AltName: Full=Protein FAM4A1;
DE AltName: Full=Protein HELG;
GN Name=ST7; Synonyms=FAM4A1, HELG, RAY1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RX PubMed=10889047; DOI=10.1086/303005;
RA Vincent J.B., Herbrick J.-A., Gurling H.M.D., Bolton P.F., Roberts W.,
RA Scherer S.W.;
RT "Identification of a novel gene on chromosome 7q31 that is interrupted by a
RT translocation breakpoint in an autistic individual.";
RL Am. J. Hum. Genet. 67:510-514(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5), AND TISSUE SPECIFICITY.
RX PubMed=11279520; DOI=10.1038/86891;
RA Zenklusen J.C., Conti C.J., Green E.D.;
RT "Mutational and functional analyses reveal that ST7 is a highly conserved
RT tumor-suppressor gene on human chromosome 7q31.";
RL Nat. Genet. 27:392-398(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Duodenum, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 52-585 (ISOFORM 2).
RC TISSUE=Fibroblast;
RA Tobias E.S., Hurlstone A.F.L., McFarlane R., Black D.M.;
RT "Cloning and characterisation of the HELG gene from human chromosome
RT 7q31.1.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 121-585 (ISOFORM 7), ALTERNATIVE SPLICING,
RP AND VARIANT VAL-361.
RX PubMed=12213198; DOI=10.1006/geno.2002.6835;
RA Vincent J.B., Petek E., Thevarkunnel S., Kolozsvari D., Cheung J.,
RA Patel M., Scherer S.W.;
RT "The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a
RT complex multi-transcript system.";
RL Genomics 80:283-294(2002).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 193-585 (ISOFORM 2).
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [11]
RP FUNCTION.
RX PubMed=16474848; DOI=10.1038/sj.onc.1209418;
RA Hooi C.S.-F., Blancher C., Qiu W., Revet I.M., Williams L.H.,
RA Ciavarella M.L., Anderson R.L., Thompson E.W., Connor A., Phillips W.A.,
RA Campbell I.G.;
RT "ST7-mediated suppression of tumorigenicity of prostate cancer cells is
RT characterized by remodeling of the extracellular matrix.";
RL Oncogene 25:3924-3933(2006).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [13]
RP VARIANT THR-186.
RX PubMed=11726923; DOI=10.1038/ng784;
RA Thomas N.A., Choong D.Y., Jokubaitis V.J., Neville P.J., Campbell I.G.;
RT "Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast,
RT ovarian and colorectal cancers.";
RL Nat. Genet. 29:379-380(2001).
CC -!- FUNCTION: May act as a tumor suppressor. {ECO:0000269|PubMed:16474848}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q9NRC1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NRC1-2; Sequence=VSP_034113, VSP_034117;
CC Name=3;
CC IsoId=Q9NRC1-3; Sequence=VSP_034112, VSP_034113, VSP_034117;
CC Name=4;
CC IsoId=Q9NRC1-4; Sequence=VSP_034109, VSP_034110, VSP_034117;
CC Name=5;
CC IsoId=Q9NRC1-5; Sequence=VSP_034109, VSP_034110, VSP_034113,
CC VSP_034117;
CC Name=6;
CC IsoId=Q9NRC1-6; Sequence=VSP_034108, VSP_034111, VSP_034113,
CC VSP_034116, VSP_034117;
CC Name=7;
CC IsoId=Q9NRC1-7; Sequence=VSP_034113, VSP_034114, VSP_034115;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in
CC heart, liver and pancreas. {ECO:0000269|PubMed:10889047,
CC ECO:0000269|PubMed:11279520}.
CC -!- SIMILARITY: Belongs to the ST7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB86869.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=EAW83520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF234882; AAF85945.1; -; mRNA.
DR EMBL; AF234883; AAF85946.1; -; mRNA.
DR EMBL; AY009152; AAG37720.1; -; mRNA.
DR EMBL; AY009153; AAG37721.1; -; mRNA.
DR EMBL; AK093212; BAC04097.1; -; mRNA.
DR EMBL; CH236947; EAL24356.1; -; Genomic_DNA.
DR EMBL; CH236947; EAL24357.1; -; Genomic_DNA.
DR EMBL; AC002542; AAS07414.1; -; Genomic_DNA.
DR EMBL; AC002542; AAS07415.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83520.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC030954; AAH30954.1; -; mRNA.
DR EMBL; BC075855; AAH75855.1; -; mRNA.
DR EMBL; AF415174; AAL85662.1; -; mRNA.
DR EMBL; CR936656; CAI56794.1; -; mRNA.
DR EMBL; AJ277291; CAB86869.1; ALT_INIT; mRNA.
DR CCDS; CCDS5769.1; -. [Q9NRC1-2]
DR CCDS; CCDS5770.1; -. [Q9NRC1-1]
DR PIR; T50625; T50625.
DR RefSeq; NP_060882.2; NM_018412.3. [Q9NRC1-2]
DR RefSeq; NP_068708.1; NM_021908.2. [Q9NRC1-1]
DR AlphaFoldDB; Q9NRC1; -.
DR BioGRID; 113695; 371.
DR IntAct; Q9NRC1; 24.
DR MINT; Q9NRC1; -.
DR STRING; 9606.ENSP00000265437; -.
DR GlyGen; Q9NRC1; 1 site.
DR iPTMnet; Q9NRC1; -.
DR PhosphoSitePlus; Q9NRC1; -.
DR BioMuta; ST7; -.
DR DMDM; 74734319; -.
DR EPD; Q9NRC1; -.
DR jPOST; Q9NRC1; -.
DR MassIVE; Q9NRC1; -.
DR MaxQB; Q9NRC1; -.
DR PaxDb; Q9NRC1; -.
DR PeptideAtlas; Q9NRC1; -.
DR PRIDE; Q9NRC1; -.
DR ProteomicsDB; 82326; -. [Q9NRC1-1]
DR ProteomicsDB; 82327; -. [Q9NRC1-2]
DR ProteomicsDB; 82328; -. [Q9NRC1-3]
DR ProteomicsDB; 82329; -. [Q9NRC1-4]
DR ProteomicsDB; 82330; -. [Q9NRC1-5]
DR ProteomicsDB; 82331; -. [Q9NRC1-6]
DR ProteomicsDB; 82332; -. [Q9NRC1-7]
DR TopDownProteomics; Q9NRC1-1; -. [Q9NRC1-1]
DR Antibodypedia; 31620; 131 antibodies from 26 providers.
DR DNASU; 7982; -.
DR Ensembl; ENST00000265437.9; ENSP00000265437.5; ENSG00000004866.22. [Q9NRC1-1]
DR Ensembl; ENST00000393443.5; ENSP00000377089.1; ENSG00000004866.22. [Q9NRC1-6]
DR Ensembl; ENST00000393451.7; ENSP00000377097.3; ENSG00000004866.22. [Q9NRC1-2]
DR GeneID; 7982; -.
DR KEGG; hsa:7982; -.
DR UCSC; uc003vio.4; human. [Q9NRC1-1]
DR CTD; 7982; -.
DR DisGeNET; 7982; -.
DR GeneCards; ST7; -.
DR HGNC; HGNC:11351; ST7.
DR HPA; ENSG00000004866; Low tissue specificity.
DR MIM; 600833; gene.
DR neXtProt; NX_Q9NRC1; -.
DR OpenTargets; ENSG00000004866; -.
DR PharmGKB; PA36173; -.
DR VEuPathDB; HostDB:ENSG00000004866; -.
DR eggNOG; KOG3807; Eukaryota.
DR GeneTree; ENSGT00390000000873; -.
DR InParanoid; Q9NRC1; -.
DR OMA; LLPSWHE; -.
DR PhylomeDB; Q9NRC1; -.
DR TreeFam; TF314162; -.
DR PathwayCommons; Q9NRC1; -.
DR SignaLink; Q9NRC1; -.
DR BioGRID-ORCS; 7982; 12 hits in 1073 CRISPR screens.
DR ChiTaRS; ST7; human.
DR GeneWiki; ST7; -.
DR GenomeRNAi; 7982; -.
DR Pharos; Q9NRC1; Tbio.
DR PRO; PR:Q9NRC1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9NRC1; protein.
DR Bgee; ENSG00000004866; Expressed in cortical plate and 193 other tissues.
DR ExpressionAtlas; Q9NRC1; baseline and differential.
DR Genevisible; Q9NRC1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; NAS:BHF-UCL.
DR GO; GO:0045595; P:regulation of cell differentiation; NAS:BHF-UCL.
DR CDD; cd11557; ST7; 1.
DR InterPro; IPR007311; ST7.
DR PANTHER; PTHR12745; PTHR12745; 1.
DR Pfam; PF04184; ST7; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..585
FT /note="Suppressor of tumorigenicity 7 protein"
FT /id="PRO_0000339202"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 386
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..50
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034108"
FT VAR_SEQ 1..26
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:11279520"
FT /id="VSP_034109"
FT VAR_SEQ 27..50
FT /note="WFFIVLFLVYILRVPLKINDNLST -> MFGTESS (in isoform 4
FT and isoform 5)"
FT /evidence="ECO:0000303|PubMed:11279520"
FT /id="VSP_034110"
FT VAR_SEQ 51
FT /note="V -> M (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034111"
FT VAR_SEQ 116..122
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034112"
FT VAR_SEQ 215..237
FT /note="Missing (in isoform 2, isoform 3, isoform 5, isoform
FT 6 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:10889047,
FT ECO:0000303|PubMed:11279520, ECO:0000303|PubMed:12213198,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005, ECO:0000303|Ref.8"
FT /id="VSP_034113"
FT VAR_SEQ 419..422
FT /note="YLLE -> ARWK (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:12213198"
FT /id="VSP_034114"
FT VAR_SEQ 423..585
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:12213198"
FT /id="VSP_034115"
FT VAR_SEQ 464..469
FT /note="CTWEGT -> S (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034116"
FT VAR_SEQ 547..585
FT /note="MIDIFCSAEFRDWNCKSIFMRVEDELEIPPAPQSQHFQN -> FLSTLFAPL
FT NFVMEKVESILPSSLWHQLTRI (in isoform 2, isoform 3, isoform 4,
FT isoform 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:10889047,
FT ECO:0000303|PubMed:11279520, ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:17974005,
FT ECO:0000303|Ref.8"
FT /id="VSP_034117"
FT VARIANT 186
FT /note="A -> T (in dbSNP:rs201219065)"
FT /evidence="ECO:0000269|PubMed:11726923"
FT /id="VAR_043932"
FT VARIANT 361
FT /note="I -> V (in dbSNP:rs1362000016)"
FT /evidence="ECO:0000269|PubMed:12213198"
FT /id="VAR_043933"
SQ SEQUENCE 585 AA; 67166 MW; 7BA8974E564B307F CRC64;
MAEAATGFLE QLKSCIVWSW TYLWTVWFFI VLFLVYILRV PLKINDNLST VSMFLNTLTP
KFYVALTGTS SLISGLILIF EWWYFRKYGT SFIEQVSVSH LRPLLGGVDN NSSNNSNSSN
GDSDSNRQSV SECKVWRNPL NLFRGAEYNR YTWVTGREPL TYYDMNLSAQ DHQTFFTCDS
DHLRPADAIM QKAWRERNPQ ARISAAHEAL EINEIRSRVE VPLIASSTIW EIKLLPKCAT
AYILLAEEEA TTIAEAEKLF KQALKAGDGC YRRSQQLQHH GSQYEAQHRR DTNVLVYIKR
RLAMCARRLG RTREAVKMMR DLMKEFPLLS MFNIHENLLE ALLELQAYAD VQAVLAKYDD
ISLPKSATIC YTAALLKARA VSDKFSPEAA SRRGLSTAEM NAVEAIHRAV EFNPHVPKYL
LEMKSLILPP EHILKRGDSE AIAYAFFHLA HWKRVEGALN LLHCTWEGTF RMIPYPLEKG
HLFYPYPICT ETADRELLPS FHEVSVYPKK ELPFFILFTA GLCSFTAMLA LLTHQFPELM
GVFAKAMIDI FCSAEFRDWN CKSIFMRVED ELEIPPAPQS QHFQN
