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ST7_MOUSE
ID   ST7_MOUSE               Reviewed;         577 AA.
AC   Q99M96; Q3UA20; Q6Q9W2; Q6Q9W3; Q8R3T3; Q921F6; Q99M89; Q99M90; Q99M91;
AC   Q99M92; Q99M93; Q99M94; Q9JID7; Q9JID8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Suppressor of tumorigenicity 7 protein;
DE   AltName: Full=mRay;
GN   Name=St7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8 AND 9).
RX   PubMed=10889047; DOI=10.1086/303005;
RA   Vincent J.B., Herbrick J.-A., Gurling H.M.D., Bolton P.F., Roberts W.,
RA   Scherer S.W.;
RT   "Identification of a novel gene on chromosome 7q31 that is interrupted by a
RT   translocation breakpoint in an autistic individual.";
RL   Am. J. Hum. Genet. 67:510-514(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4; 5; 6; 7; 8 AND 9).
RC   STRAIN=BALB/cJ;
RX   PubMed=11279520; DOI=10.1038/86891;
RA   Zenklusen J.C., Conti C.J., Green E.D.;
RT   "Mutational and functional analyses reveal that ST7 is a highly conserved
RT   tumor-suppressor gene on human chromosome 7q31.";
RL   Nat. Genet. 27:392-398(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8 AND 9).
RC   STRAIN=SWR/J; TISSUE=Lung;
RX   PubMed=15592501; DOI=10.1038/sj.onc.1208324;
RA   Zaffaroni D., Spinola M., Galvan A., Falvella F.S., Pazzaglia S., Saran A.,
RA   Mancuso M.T., Galbiati F., Pignatiello C., Cabrera W., Ibanez O.,
RA   Manenti G., Dragani T.A.;
RT   "Met proto-oncogene juxtamembrane rare variations in mouse and humans:
RT   differential effects of Arg and Cys alleles on mouse lung tumorigenesis.";
RL   Oncogene 24:1084-1090(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9).
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, and Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9).
RA   Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J.,
RA   Wiemann S., Schick M., Korn B.;
RT   "Cloning of mouse full open reading frames in Gateway(R) system entry
RT   vector (pDONR201).";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 8), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 193-577 (ISOFORM 3).
RC   STRAIN=C57BL/6J, Czech II, and FVB/N; TISSUE=Eye, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=9;
CC       Name=1;
CC         IsoId=Q99M96-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q99M96-2; Sequence=VSP_034124;
CC       Name=3;
CC         IsoId=Q99M96-3; Sequence=VSP_034123;
CC       Name=4;
CC         IsoId=Q99M96-4; Sequence=VSP_034118, VSP_034123;
CC       Name=5;
CC         IsoId=Q99M96-5; Sequence=VSP_034118;
CC       Name=6;
CC         IsoId=Q99M96-6; Sequence=VSP_034120, VSP_034121;
CC       Name=7;
CC         IsoId=Q99M96-7; Sequence=VSP_034120, VSP_034121, VSP_034123;
CC       Name=8;
CC         IsoId=Q99M96-8; Sequence=VSP_034119, VSP_034122;
CC       Name=9;
CC         IsoId=Q99M96-9; Sequence=VSP_034119, VSP_034122, VSP_034123;
CC   -!- SIMILARITY: Belongs to the ST7 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH12719.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF234885; AAF85948.1; -; mRNA.
DR   EMBL; AF234884; AAF85947.1; -; mRNA.
DR   EMBL; AY007792; AAG24458.1; -; mRNA.
DR   EMBL; AY007794; AAG24460.1; -; mRNA.
DR   EMBL; AY007795; AAG24461.1; -; mRNA.
DR   EMBL; AY007796; AAG24462.1; -; mRNA.
DR   EMBL; AY007797; AAG24463.1; -; mRNA.
DR   EMBL; AY007798; AAG24464.1; -; mRNA.
DR   EMBL; AY007799; AAG24465.1; -; mRNA.
DR   EMBL; AY551821; AAS59839.1; -; mRNA.
DR   EMBL; AY551822; AAS59840.1; -; mRNA.
DR   EMBL; AK132103; BAE20983.1; -; mRNA.
DR   EMBL; AK151550; BAE30495.1; -; mRNA.
DR   EMBL; CT010245; CAJ18453.1; -; mRNA.
DR   EMBL; BC012719; AAH12719.1; ALT_INIT; mRNA.
DR   EMBL; BC024652; AAH24652.1; -; mRNA.
DR   EMBL; BC108418; AAI08419.1; -; mRNA.
DR   CCDS; CCDS19927.1; -. [Q99M96-8]
DR   CCDS; CCDS39431.1; -. [Q99M96-9]
DR   CCDS; CCDS71728.1; -. [Q99M96-1]
DR   CCDS; CCDS71729.1; -. [Q99M96-3]
DR   CCDS; CCDS71730.1; -. [Q99M96-6]
DR   CCDS; CCDS71731.1; -. [Q99M96-7]
DR   CCDS; CCDS80490.1; -. [Q99M96-2]
DR   RefSeq; NP_001076784.1; NM_001083315.2. [Q99M96-9]
DR   RefSeq; NP_001276553.1; NM_001289624.1. [Q99M96-1]
DR   RefSeq; NP_001276554.1; NM_001289625.1. [Q99M96-2]
DR   RefSeq; NP_001276556.1; NM_001289627.1. [Q99M96-6]
DR   RefSeq; NP_001276558.1; NM_001289629.1. [Q99M96-7]
DR   RefSeq; NP_071727.2; NM_022332.3. [Q99M96-8]
DR   RefSeq; XP_011239376.1; XM_011241074.1.
DR   AlphaFoldDB; Q99M96; -.
DR   STRING; 10090.ENSMUSP00000057326; -.
DR   GlyGen; Q99M96; 1 site.
DR   iPTMnet; Q99M96; -.
DR   PhosphoSitePlus; Q99M96; -.
DR   MaxQB; Q99M96; -.
DR   PaxDb; Q99M96; -.
DR   PRIDE; Q99M96; -.
DR   ProteomicsDB; 257433; -. [Q99M96-1]
DR   ProteomicsDB; 257434; -. [Q99M96-2]
DR   ProteomicsDB; 257435; -. [Q99M96-3]
DR   ProteomicsDB; 257436; -. [Q99M96-4]
DR   ProteomicsDB; 257437; -. [Q99M96-5]
DR   ProteomicsDB; 257438; -. [Q99M96-6]
DR   ProteomicsDB; 257439; -. [Q99M96-7]
DR   ProteomicsDB; 257440; -. [Q99M96-8]
DR   ProteomicsDB; 257441; -. [Q99M96-9]
DR   Ensembl; ENSMUST00000000674; ENSMUSP00000000674; ENSMUSG00000029534. [Q99M96-7]
DR   Ensembl; ENSMUST00000052113; ENSMUSP00000062886; ENSMUSG00000029534. [Q99M96-3]
DR   Ensembl; ENSMUST00000053148; ENSMUSP00000057326; ENSMUSG00000029534. [Q99M96-8]
DR   Ensembl; ENSMUST00000077080; ENSMUSP00000076334; ENSMUSG00000029534. [Q99M96-6]
DR   Ensembl; ENSMUST00000081635; ENSMUSP00000080341; ENSMUSG00000029534. [Q99M96-1]
DR   Ensembl; ENSMUST00000115417; ENSMUSP00000111077; ENSMUSG00000029534. [Q99M96-9]
DR   Ensembl; ENSMUST00000115419; ENSMUSP00000111079; ENSMUSG00000029534. [Q99M96-2]
DR   GeneID; 64213; -.
DR   KEGG; mmu:64213; -.
DR   UCSC; uc009azu.2; mouse. [Q99M96-2]
DR   UCSC; uc009azv.2; mouse. [Q99M96-1]
DR   UCSC; uc009azx.2; mouse. [Q99M96-7]
DR   UCSC; uc009azy.2; mouse. [Q99M96-6]
DR   UCSC; uc009bac.2; mouse. [Q99M96-8]
DR   UCSC; uc009bae.2; mouse. [Q99M96-9]
DR   CTD; 7982; -.
DR   MGI; MGI:1927450; St7.
DR   VEuPathDB; HostDB:ENSMUSG00000029534; -.
DR   eggNOG; KOG3807; Eukaryota.
DR   GeneTree; ENSGT00390000000873; -.
DR   HOGENOM; CLU_035578_2_0_1; -.
DR   InParanoid; Q99M96; -.
DR   OMA; LLPSWHE; -.
DR   OrthoDB; 540550at2759; -.
DR   PhylomeDB; Q99M96; -.
DR   TreeFam; TF314162; -.
DR   BioGRID-ORCS; 64213; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; St7; mouse.
DR   PRO; PR:Q99M96; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q99M96; protein.
DR   Bgee; ENSMUSG00000029534; Expressed in saccule of membranous labyrinth and 223 other tissues.
DR   ExpressionAtlas; Q99M96; baseline and differential.
DR   Genevisible; Q99M96; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd11557; ST7; 1.
DR   InterPro; IPR007311; ST7.
DR   PANTHER; PTHR12745; PTHR12745; 1.
DR   Pfam; PF04184; ST7; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..577
FT                   /note="Suppressor of tumorigenicity 7 protein"
FT                   /id="PRO_0000339207"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        512..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        539..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         386
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRC1"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..51
FT                   /note="MAEAGAGFLEQLKSCIVWSWTYLWTVWFFLVLFLVYILRVPLRINDNLSTV
FT                   -> MQEGKQITCSHVKLLPSRLPEHAFM (in isoform 4 and isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:11279520"
FT                   /id="VSP_034118"
FT   VAR_SEQ         1..26
FT                   /note="Missing (in isoform 8 and isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:10889047,
FT                   ECO:0000303|PubMed:11279520, ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:15592501, ECO:0000303|PubMed:16141072,
FT                   ECO:0000303|Ref.5"
FT                   /id="VSP_034119"
FT   VAR_SEQ         1..19
FT                   /note="Missing (in isoform 6 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:11279520"
FT                   /id="VSP_034120"
FT   VAR_SEQ         20..50
FT                   /note="WTYLWTVWFFLVLFLVYILRVPLRINDNLST -> MKYA (in isoform
FT                   6 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:11279520"
FT                   /id="VSP_034121"
FT   VAR_SEQ         27..51
FT                   /note="WFFLVLFLVYILRVPLRINDNLSTV -> MFGTESSL (in isoform 8
FT                   and isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:10889047,
FT                   ECO:0000303|PubMed:11279520, ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:15592501, ECO:0000303|PubMed:16141072,
FT                   ECO:0000303|Ref.5"
FT                   /id="VSP_034122"
FT   VAR_SEQ         215..237
FT                   /note="Missing (in isoform 3, isoform 4, isoform 7 and
FT                   isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:10889047,
FT                   ECO:0000303|PubMed:11279520, ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:15592501, ECO:0000303|PubMed:16141072,
FT                   ECO:0000303|Ref.5"
FT                   /id="VSP_034123"
FT   VAR_SEQ         464..469
FT                   /note="CTWEGT -> S (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_034124"
FT   CONFLICT        102
FT                   /note="R -> C (in Ref. 2; AAG24465/AAG24464)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        308
FT                   /note="R -> G (in Ref. 4; BAE30495)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   577 AA;  66095 MW;  23E90053FAEBB71F CRC64;
     MAEAGAGFLE QLKSCIVWSW TYLWTVWFFL VLFLVYILRV PLRINDNLST VSMFLNTLTP
     KFYVALTGTS SLISGLILIF EWWYFRKYGT SFIEQVSVSH LRPLLGGVDN NSSNNSNSSN
     GDSDSNRQSV SECKVWRNPL NLFRGAEYNR YTWVTGREPL TYYDMNLSAQ DHQTFFTCDS
     DHLRPADAIM QKAWRERNPQ ARISAAHEAL EINEIRSRVE VPLIASSTIW EIKLLPKCAT
     AYILLAEEEA TTIAEAEKLF KQALKAGDGC YRRSQQLQHH GSQYEAQHRR DTNVLVYIKR
     RLAMCARRLG RTREAVKMMR DLMKEFPLLS MFNIHENLLE ALLELQAYAD VQAVLAKYDD
     ISLPKSATIC YTAALLKARA VSDKFSPEAA SRRGLSTAEM NAVEAIHRAV EFNPHVPKYL
     LEMKSLILPP EHILKRGDSE AIAYAFFHLA HWKRVEGALN LLHCTWEGTF RMIPYPLEKG
     HLFYPYPICT ETADRELLPS FHEVSVYPKK ELPFFILFTA GLCSFTAMLA LLTHQFPELM
     GVFAKAFLST LFAPLNFVME KVESILPSSL WHQLTRI
 
 
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