ST7_MOUSE
ID ST7_MOUSE Reviewed; 577 AA.
AC Q99M96; Q3UA20; Q6Q9W2; Q6Q9W3; Q8R3T3; Q921F6; Q99M89; Q99M90; Q99M91;
AC Q99M92; Q99M93; Q99M94; Q9JID7; Q9JID8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Suppressor of tumorigenicity 7 protein;
DE AltName: Full=mRay;
GN Name=St7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8 AND 9).
RX PubMed=10889047; DOI=10.1086/303005;
RA Vincent J.B., Herbrick J.-A., Gurling H.M.D., Bolton P.F., Roberts W.,
RA Scherer S.W.;
RT "Identification of a novel gene on chromosome 7q31 that is interrupted by a
RT translocation breakpoint in an autistic individual.";
RL Am. J. Hum. Genet. 67:510-514(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4; 5; 6; 7; 8 AND 9).
RC STRAIN=BALB/cJ;
RX PubMed=11279520; DOI=10.1038/86891;
RA Zenklusen J.C., Conti C.J., Green E.D.;
RT "Mutational and functional analyses reveal that ST7 is a highly conserved
RT tumor-suppressor gene on human chromosome 7q31.";
RL Nat. Genet. 27:392-398(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8 AND 9).
RC STRAIN=SWR/J; TISSUE=Lung;
RX PubMed=15592501; DOI=10.1038/sj.onc.1208324;
RA Zaffaroni D., Spinola M., Galvan A., Falvella F.S., Pazzaglia S., Saran A.,
RA Mancuso M.T., Galbiati F., Pignatiello C., Cabrera W., Ibanez O.,
RA Manenti G., Dragani T.A.;
RT "Met proto-oncogene juxtamembrane rare variations in mouse and humans:
RT differential effects of Arg and Cys alleles on mouse lung tumorigenesis.";
RL Oncogene 24:1084-1090(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9).
RA Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J.,
RA Wiemann S., Schick M., Korn B.;
RT "Cloning of mouse full open reading frames in Gateway(R) system entry
RT vector (pDONR201).";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 8), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 193-577 (ISOFORM 3).
RC STRAIN=C57BL/6J, Czech II, and FVB/N; TISSUE=Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=1;
CC IsoId=Q99M96-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99M96-2; Sequence=VSP_034124;
CC Name=3;
CC IsoId=Q99M96-3; Sequence=VSP_034123;
CC Name=4;
CC IsoId=Q99M96-4; Sequence=VSP_034118, VSP_034123;
CC Name=5;
CC IsoId=Q99M96-5; Sequence=VSP_034118;
CC Name=6;
CC IsoId=Q99M96-6; Sequence=VSP_034120, VSP_034121;
CC Name=7;
CC IsoId=Q99M96-7; Sequence=VSP_034120, VSP_034121, VSP_034123;
CC Name=8;
CC IsoId=Q99M96-8; Sequence=VSP_034119, VSP_034122;
CC Name=9;
CC IsoId=Q99M96-9; Sequence=VSP_034119, VSP_034122, VSP_034123;
CC -!- SIMILARITY: Belongs to the ST7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH12719.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF234885; AAF85948.1; -; mRNA.
DR EMBL; AF234884; AAF85947.1; -; mRNA.
DR EMBL; AY007792; AAG24458.1; -; mRNA.
DR EMBL; AY007794; AAG24460.1; -; mRNA.
DR EMBL; AY007795; AAG24461.1; -; mRNA.
DR EMBL; AY007796; AAG24462.1; -; mRNA.
DR EMBL; AY007797; AAG24463.1; -; mRNA.
DR EMBL; AY007798; AAG24464.1; -; mRNA.
DR EMBL; AY007799; AAG24465.1; -; mRNA.
DR EMBL; AY551821; AAS59839.1; -; mRNA.
DR EMBL; AY551822; AAS59840.1; -; mRNA.
DR EMBL; AK132103; BAE20983.1; -; mRNA.
DR EMBL; AK151550; BAE30495.1; -; mRNA.
DR EMBL; CT010245; CAJ18453.1; -; mRNA.
DR EMBL; BC012719; AAH12719.1; ALT_INIT; mRNA.
DR EMBL; BC024652; AAH24652.1; -; mRNA.
DR EMBL; BC108418; AAI08419.1; -; mRNA.
DR CCDS; CCDS19927.1; -. [Q99M96-8]
DR CCDS; CCDS39431.1; -. [Q99M96-9]
DR CCDS; CCDS71728.1; -. [Q99M96-1]
DR CCDS; CCDS71729.1; -. [Q99M96-3]
DR CCDS; CCDS71730.1; -. [Q99M96-6]
DR CCDS; CCDS71731.1; -. [Q99M96-7]
DR CCDS; CCDS80490.1; -. [Q99M96-2]
DR RefSeq; NP_001076784.1; NM_001083315.2. [Q99M96-9]
DR RefSeq; NP_001276553.1; NM_001289624.1. [Q99M96-1]
DR RefSeq; NP_001276554.1; NM_001289625.1. [Q99M96-2]
DR RefSeq; NP_001276556.1; NM_001289627.1. [Q99M96-6]
DR RefSeq; NP_001276558.1; NM_001289629.1. [Q99M96-7]
DR RefSeq; NP_071727.2; NM_022332.3. [Q99M96-8]
DR RefSeq; XP_011239376.1; XM_011241074.1.
DR AlphaFoldDB; Q99M96; -.
DR STRING; 10090.ENSMUSP00000057326; -.
DR GlyGen; Q99M96; 1 site.
DR iPTMnet; Q99M96; -.
DR PhosphoSitePlus; Q99M96; -.
DR MaxQB; Q99M96; -.
DR PaxDb; Q99M96; -.
DR PRIDE; Q99M96; -.
DR ProteomicsDB; 257433; -. [Q99M96-1]
DR ProteomicsDB; 257434; -. [Q99M96-2]
DR ProteomicsDB; 257435; -. [Q99M96-3]
DR ProteomicsDB; 257436; -. [Q99M96-4]
DR ProteomicsDB; 257437; -. [Q99M96-5]
DR ProteomicsDB; 257438; -. [Q99M96-6]
DR ProteomicsDB; 257439; -. [Q99M96-7]
DR ProteomicsDB; 257440; -. [Q99M96-8]
DR ProteomicsDB; 257441; -. [Q99M96-9]
DR Ensembl; ENSMUST00000000674; ENSMUSP00000000674; ENSMUSG00000029534. [Q99M96-7]
DR Ensembl; ENSMUST00000052113; ENSMUSP00000062886; ENSMUSG00000029534. [Q99M96-3]
DR Ensembl; ENSMUST00000053148; ENSMUSP00000057326; ENSMUSG00000029534. [Q99M96-8]
DR Ensembl; ENSMUST00000077080; ENSMUSP00000076334; ENSMUSG00000029534. [Q99M96-6]
DR Ensembl; ENSMUST00000081635; ENSMUSP00000080341; ENSMUSG00000029534. [Q99M96-1]
DR Ensembl; ENSMUST00000115417; ENSMUSP00000111077; ENSMUSG00000029534. [Q99M96-9]
DR Ensembl; ENSMUST00000115419; ENSMUSP00000111079; ENSMUSG00000029534. [Q99M96-2]
DR GeneID; 64213; -.
DR KEGG; mmu:64213; -.
DR UCSC; uc009azu.2; mouse. [Q99M96-2]
DR UCSC; uc009azv.2; mouse. [Q99M96-1]
DR UCSC; uc009azx.2; mouse. [Q99M96-7]
DR UCSC; uc009azy.2; mouse. [Q99M96-6]
DR UCSC; uc009bac.2; mouse. [Q99M96-8]
DR UCSC; uc009bae.2; mouse. [Q99M96-9]
DR CTD; 7982; -.
DR MGI; MGI:1927450; St7.
DR VEuPathDB; HostDB:ENSMUSG00000029534; -.
DR eggNOG; KOG3807; Eukaryota.
DR GeneTree; ENSGT00390000000873; -.
DR HOGENOM; CLU_035578_2_0_1; -.
DR InParanoid; Q99M96; -.
DR OMA; LLPSWHE; -.
DR OrthoDB; 540550at2759; -.
DR PhylomeDB; Q99M96; -.
DR TreeFam; TF314162; -.
DR BioGRID-ORCS; 64213; 1 hit in 72 CRISPR screens.
DR ChiTaRS; St7; mouse.
DR PRO; PR:Q99M96; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q99M96; protein.
DR Bgee; ENSMUSG00000029534; Expressed in saccule of membranous labyrinth and 223 other tissues.
DR ExpressionAtlas; Q99M96; baseline and differential.
DR Genevisible; Q99M96; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd11557; ST7; 1.
DR InterPro; IPR007311; ST7.
DR PANTHER; PTHR12745; PTHR12745; 1.
DR Pfam; PF04184; ST7; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..577
FT /note="Suppressor of tumorigenicity 7 protein"
FT /id="PRO_0000339207"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 539..559
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 386
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NRC1"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..51
FT /note="MAEAGAGFLEQLKSCIVWSWTYLWTVWFFLVLFLVYILRVPLRINDNLSTV
FT -> MQEGKQITCSHVKLLPSRLPEHAFM (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:11279520"
FT /id="VSP_034118"
FT VAR_SEQ 1..26
FT /note="Missing (in isoform 8 and isoform 9)"
FT /evidence="ECO:0000303|PubMed:10889047,
FT ECO:0000303|PubMed:11279520, ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15592501, ECO:0000303|PubMed:16141072,
FT ECO:0000303|Ref.5"
FT /id="VSP_034119"
FT VAR_SEQ 1..19
FT /note="Missing (in isoform 6 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:11279520"
FT /id="VSP_034120"
FT VAR_SEQ 20..50
FT /note="WTYLWTVWFFLVLFLVYILRVPLRINDNLST -> MKYA (in isoform
FT 6 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:11279520"
FT /id="VSP_034121"
FT VAR_SEQ 27..51
FT /note="WFFLVLFLVYILRVPLRINDNLSTV -> MFGTESSL (in isoform 8
FT and isoform 9)"
FT /evidence="ECO:0000303|PubMed:10889047,
FT ECO:0000303|PubMed:11279520, ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15592501, ECO:0000303|PubMed:16141072,
FT ECO:0000303|Ref.5"
FT /id="VSP_034122"
FT VAR_SEQ 215..237
FT /note="Missing (in isoform 3, isoform 4, isoform 7 and
FT isoform 9)"
FT /evidence="ECO:0000303|PubMed:10889047,
FT ECO:0000303|PubMed:11279520, ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15592501, ECO:0000303|PubMed:16141072,
FT ECO:0000303|Ref.5"
FT /id="VSP_034123"
FT VAR_SEQ 464..469
FT /note="CTWEGT -> S (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034124"
FT CONFLICT 102
FT /note="R -> C (in Ref. 2; AAG24465/AAG24464)"
FT /evidence="ECO:0000305"
FT CONFLICT 308
FT /note="R -> G (in Ref. 4; BAE30495)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 577 AA; 66095 MW; 23E90053FAEBB71F CRC64;
MAEAGAGFLE QLKSCIVWSW TYLWTVWFFL VLFLVYILRV PLRINDNLST VSMFLNTLTP
KFYVALTGTS SLISGLILIF EWWYFRKYGT SFIEQVSVSH LRPLLGGVDN NSSNNSNSSN
GDSDSNRQSV SECKVWRNPL NLFRGAEYNR YTWVTGREPL TYYDMNLSAQ DHQTFFTCDS
DHLRPADAIM QKAWRERNPQ ARISAAHEAL EINEIRSRVE VPLIASSTIW EIKLLPKCAT
AYILLAEEEA TTIAEAEKLF KQALKAGDGC YRRSQQLQHH GSQYEAQHRR DTNVLVYIKR
RLAMCARRLG RTREAVKMMR DLMKEFPLLS MFNIHENLLE ALLELQAYAD VQAVLAKYDD
ISLPKSATIC YTAALLKARA VSDKFSPEAA SRRGLSTAEM NAVEAIHRAV EFNPHVPKYL
LEMKSLILPP EHILKRGDSE AIAYAFFHLA HWKRVEGALN LLHCTWEGTF RMIPYPLEKG
HLFYPYPICT ETADRELLPS FHEVSVYPKK ELPFFILFTA GLCSFTAMLA LLTHQFPELM
GVFAKAFLST LFAPLNFVME KVESILPSSL WHQLTRI