ST7_RAT
ID ST7_RAT Reviewed; 577 AA.
AC Q2IBD0; Q499P1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Suppressor of tumorigenicity 7 protein;
GN Name=St7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=12917688; DOI=10.1038/nature01858;
RA Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G.,
RA Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C.,
RA Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S.,
RA Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R., Cutler D.J.,
RA Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q.,
RA Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N.,
RA Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S.,
RA Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E.,
RA Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A.,
RA Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E.,
RA Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D.,
RA Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B.,
RA Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A.,
RA Haussler D., Green P., Miller W., Green E.D.;
RT "Comparative analyses of multi-species sequences from targeted genomic
RT regions.";
RL Nature 424:788-793(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2IBD0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2IBD0-2; Sequence=VSP_034125, VSP_034126;
CC -!- SIMILARITY: Belongs to the ST7 family. {ECO:0000305}.
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DR EMBL; DP000027; AAR16311.1; -; Genomic_DNA.
DR EMBL; BC099820; AAH99820.1; -; mRNA.
DR RefSeq; XP_006236194.1; XM_006236132.3. [Q2IBD0-1]
DR AlphaFoldDB; Q2IBD0; -.
DR STRING; 10116.ENSRNOP00000010219; -.
DR GlyGen; Q2IBD0; 1 site.
DR PhosphoSitePlus; Q2IBD0; -.
DR PaxDb; Q2IBD0; -.
DR PRIDE; Q2IBD0; -.
DR Ensembl; ENSRNOT00000084736; ENSRNOP00000071529; ENSRNOG00000056243. [Q2IBD0-2]
DR GeneID; 296911; -.
DR UCSC; RGD:1303148; rat. [Q2IBD0-1]
DR CTD; 7982; -.
DR RGD; 1303148; ST7.
DR VEuPathDB; HostDB:ENSRNOG00000056243; -.
DR eggNOG; KOG3807; Eukaryota.
DR GeneTree; ENSGT00390000000873; -.
DR InParanoid; Q2IBD0; -.
DR OrthoDB; 540550at2759; -.
DR PhylomeDB; Q2IBD0; -.
DR TreeFam; TF314162; -.
DR PRO; PR:Q2IBD0; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000056243; Expressed in pancreas and 18 other tissues.
DR ExpressionAtlas; Q2IBD0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd11557; ST7; 1.
DR InterPro; IPR007311; ST7.
DR PANTHER; PTHR12745; PTHR12745; 1.
DR Pfam; PF04184; ST7; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..577
FT /note="Suppressor of tumorigenicity 7 protein"
FT /id="PRO_0000339215"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 539..559
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 386
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NRC1"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 215..237
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034125"
FT VAR_SEQ 470..500
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034126"
FT CONFLICT 6
FT /note="S -> A (in Ref. 2; AAH99820)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 577 AA; 66111 MW; E3256054BD796258 CRC64;
MAEAGSGFLE QLKSCIVWSW TYLWTVWFFL VLFLVYILRV PLRINDNLST VSMFLNTLTP
KFYVALTGTS SLISGLILIF EWWYFRKYGT SFIEQVSVSH LRPLLGGVDN NSSNNSNSSN
GDSDSNRQSV SECKVWRNPL NLFRGAEYNR YTWVTGREPL TYYDMNLSAQ DHQTFFTCDS
DHLRPADAIM QKAWRERNPQ ARISAAHEAL EINEIRSRVE VPLIASSTIW EIKLLPKCAT
AYILLAEEEA TTIAEAEKLF KQALKAGDGC YRRSQQLQHH GSQYEAQHRR DTNVLVYIKR
RLAMCARRLG RTREAVKMMR DLMKEFPLLS MFNIHENLLE ALLELQAYAD VQAVLAKYDD
ISLPKSATIC YTAALLKARA VSDKFSPEAA SRRGLSTAEM NAVEAIHRAV EFNPHVPKYL
LEMKSLILPP EHILKRGDSE AIAYAFFHLA HWKRVEGALN LLHCTWEGTF RMIPYPLEKG
HLFYPYPICT ETADRELLPS FHEVSVYPKK ELPFFILFTA GLCSFTAMLA LLTHQFPELM
GVFAKAFLST LFAPLNFVME KVESILPSSL WHQLTRI
