STA10_MOUSE
ID STA10_MOUSE Reviewed; 291 AA.
AC Q9JMD3;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=START domain-containing protein 10;
DE Short=StARD10;
DE AltName: Full=PCTP-like protein;
DE Short=PCTP-L;
DE AltName: Full=Serologically defined colon cancer antigen 28 homolog;
DE AltName: Full=StAR-related lipid transfer protein 10;
GN Name=Stard10; Synonyms=Pctpl, Sdccag28, Sdccagg28;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC TISSUE=Testis;
RX PubMed=10819773; DOI=10.1095/biolreprod62.6.1694;
RA Yamanaka M., Koga M., Tanaka H., Nakamura Y., Ohta H., Yomogida K.,
RA Tsuchida J., Iguchi N., Nojima H., Nozaki M., Matsumiya K., Okuyama A.,
RA Toshimori K., Nishimune Y.;
RT "Molecular cloning and characterization of phosphatidylcholine transfer
RT protein-like protein gene expressed in murine haploid germ cells.";
RL Biol. Reprod. 62:1694-1701(2000).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284 AND SER-289, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-94; LYS-197 AND LYS-202, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: Phospholipid transfer protein that preferentially selects
CC lipid species containing a palmitoyl or stearoyl chain on the sn-1 and
CC an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position.
CC Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline
CC (PE) between membranes (By similarity). May play metabolic roles in
CC sperm maturation or fertilization. {ECO:0000250,
CC ECO:0000269|PubMed:10819773}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:10819773}. Cytoplasm {ECO:0000250}. Membrane
CC {ECO:0000250}. Note=Mainly cytosolic (By similarity). In testis was
CC predominantly detected at the flagella of elongated spermatids, with a
CC strong signal also found at the tail of epididymal sperm.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis, kidney, liver, and intestine with the
CC highest level in the testis.
CC -!- DEVELOPMENTAL STAGE: During male germ cell development, it was detected
CC first in the 23-day-old mouse testis, and the signal increased with
CC age.
CC -!- PTM: Phosphorylation at Ser-284 by CK2 negatively regulates lipid
CC transfer activity, possibly by decreasing membrane association.
CC {ECO:0000250}.
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DR EMBL; AB031550; BAA92233.1; -; mRNA.
DR CCDS; CCDS21509.1; -.
DR RefSeq; NP_064374.1; NM_019990.4.
DR AlphaFoldDB; Q9JMD3; -.
DR SMR; Q9JMD3; -.
DR BioGRID; 207773; 1.
DR STRING; 10090.ENSMUSP00000032927; -.
DR iPTMnet; Q9JMD3; -.
DR PhosphoSitePlus; Q9JMD3; -.
DR jPOST; Q9JMD3; -.
DR MaxQB; Q9JMD3; -.
DR PaxDb; Q9JMD3; -.
DR PRIDE; Q9JMD3; -.
DR ProteomicsDB; 257442; -.
DR Antibodypedia; 7866; 150 antibodies from 26 providers.
DR DNASU; 56018; -.
DR Ensembl; ENSMUST00000032927; ENSMUSP00000032927; ENSMUSG00000030688.
DR Ensembl; ENSMUST00000164479; ENSMUSP00000133002; ENSMUSG00000030688.
DR Ensembl; ENSMUST00000210192; ENSMUSP00000148114; ENSMUSG00000030688.
DR GeneID; 56018; -.
DR KEGG; mmu:56018; -.
DR UCSC; uc009ioi.1; mouse.
DR CTD; 10809; -.
DR MGI; MGI:1860093; Stard10.
DR VEuPathDB; HostDB:ENSMUSG00000030688; -.
DR eggNOG; KOG2761; Eukaryota.
DR GeneTree; ENSGT00510000047611; -.
DR InParanoid; Q9JMD3; -.
DR OMA; ITVWTQV; -.
DR PhylomeDB; Q9JMD3; -.
DR TreeFam; TF354285; -.
DR Reactome; R-MMU-1483191; Synthesis of PC.
DR BioGRID-ORCS; 56018; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Stard10; mouse.
DR PRO; PR:Q9JMD3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9JMD3; protein.
DR Bgee; ENSMUSG00000030688; Expressed in left lobe of liver and 258 other tissues.
DR ExpressionAtlas; Q9JMD3; baseline and differential.
DR Genevisible; Q9JMD3; MM.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0046581; C:intercellular canaliculus; IDA:MGI.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005902; C:microvillus; IDA:MGI.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0032782; P:bile acid secretion; IMP:MGI.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0035360; P:positive regulation of peroxisome proliferator activated receptor signaling pathway; IMP:MGI.
DR CDD; cd08871; START_STARD10-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR041951; STARD10_START.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR Pfam; PF01852; START; 1.
DR SMART; SM00234; START; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell projection; Cilium; Cytoplasm; Flagellum;
KW Lipid transport; Lipid-binding; Membrane; Phosphoprotein;
KW Reference proteome; Transport.
FT CHAIN 1..291
FT /note="START domain-containing protein 10"
FT /id="PRO_0000220662"
FT DOMAIN 14..224
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y365"
FT MOD_RES 94
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 197
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 202
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 253
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y365"
FT MOD_RES 259
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y365"
FT MOD_RES 284
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 289
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 291 AA; 32951 MW; 598467C430D97080 CRC64;
MEKPAASTEP QGSRPALGRE SVQVPDDQDF RSFRSECEAE VGWNLTYSKA GVSVWVQAVE
MDRTLHKIKC RMECCDVPAE TLYDVLHDIE YRKKWDSNVI ETFDIARLTV NADVGYYSWR
CPKPLKNRDV ITLRSWLPMG ADYIIMNYSV KHPKYPPRKD LVRAVSIQTG YLIQSTGPKS
CVITYLAQVD PKGSLPKWVV NKSSQFLAPK AMKKMYKACI KYPEWKQKHQ PHFKPWLHPE
QSPLPSLALS ELSVQHADSL ENIDESAVTE SREERAGGAG GEGSDDDTSL T
