STA32_XENLA
ID STA32_XENLA Reviewed; 766 AA.
AC Q7ZXK3;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Signal transducer and activator of transcription 3.2;
DE AltName: Full=Protein Stat3-A {ECO:0000312|EMBL:AAH44717.1};
GN Name=stat3.2; Synonyms=stat3-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000312|EMBL:AAH44717.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tail bud {ECO:0000312|EMBL:AAH44717.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that binds to target promoter sequences
CC and activates transcription upon il6st/gp130 stimulation. Mediates
CC ventralization of embryos, at least in part via inhibition of smad2
CC signaling. Required for hairy2 to induce dll1/delta1 and promote neural
CC crest cell proliferation and differentiation. Involved in TGFbeta-
CC mediated mesoderm induction in early embryos, acting downstream of
CC map3k7/tak1 and nlk.2 (By similarity). {ECO:0000250|UniProtKB:Q9PVX8}.
CC -!- SUBUNIT: Forms a homodimer or a heterodimer with a related family
CC member. Interacts with nlk.2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40763}. Nucleus
CC {ECO:0000250|UniProtKB:P40763}. Note=Shuttles between the nucleus and
CC the cytoplasm. Constitutive nuclear presence is independent of tyrosine
CC phosphorylation (By similarity). {ECO:0000250}.
CC -!- PTM: Phosphorylation of both tyrosine and serine residues, together
CC with dimerization, is required for mesoderm induction.
CC {ECO:0000250|UniProtKB:Q9PVX8}.
CC -!- MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
CC {ECO:0000250|UniProtKB:Q9PVX8}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000255}.
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DR EMBL; BC044717; AAH44717.1; -; mRNA.
DR RefSeq; NP_001079577.1; NM_001086108.1.
DR AlphaFoldDB; Q7ZXK3; -.
DR SMR; Q7ZXK3; -.
DR GeneID; 379264; -.
DR KEGG; xla:379264; -.
DR CTD; 379264; -.
DR Xenbase; XB-GENE-1020979; stat3.2.L.
DR OrthoDB; 327469at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 379264; Expressed in spleen and 20 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB.
DR GO; GO:0014033; P:neural crest cell differentiation; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10374; SH2_STAT3; 1.
DR Gene3D; 1.10.532.10; -; 1.
DR Gene3D; 2.60.40.630; -; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR035855; STAT3_SH2.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; PTHR11801; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF47655; SSF47655; 1.
DR SUPFAM; SSF48092; SSF48092; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; Developmental protein; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome; SH2 domain; Transcription;
KW Transcription regulation.
FT CHAIN 1..766
FT /note="Signal transducer and activator of transcription
FT 3.2"
FT /id="PRO_0000370238"
FT DOMAIN 580..670
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT MOTIF 150..162
FT /note="Essential for nuclear import"
FT /evidence="ECO:0000250"
FT MOD_RES 725
FT /note="Phosphoserine; by NLK"
FT /evidence="ECO:0000250"
SQ SEQUENCE 766 AA; 87599 MW; 31018A3321CCEB9C CRC64;
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAFAASKE SHATLVFHNL
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSTYLEKPME IARIVARCLW EEGRLLQTAV
AAAQQGGPAS HPNAAVITEK QQMLEQHLQD VRKKVQDLEQ KMKVVENLQD DFDFNYKTLK
SQSDLSELNG NNQSVTRQKM QQLEQMLTAL DQLRRTIISD LASLLSAMEY VQKNLTDEEL
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IRKLEELQQK VSYKGDPIVQ
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTNKVR LLVKFPELNY
QLKIKVCIDK DSGEGAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS
GCQITWAKFC KENMAGKGFS FWVWLDNLID LVKKYMLALW NEGYIIGFIS KERERALLSP
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF AEIIMGYKIM
DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHQEPTDP GTAPYLRTMF ICVTPTTCTL
DLPMSPGTFD SVMQFPGEGS ESGNGNQFET LTFDVDLPSE CAASPM