STAR5_HUMAN
ID STAR5_HUMAN Reviewed; 213 AA.
AC Q9NSY2; P59094;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 15-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=StAR-related lipid transfer protein 5;
DE AltName: Full=START domain-containing protein 5;
DE Short=StARD5;
GN Name=STARD5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=12011452; DOI=10.1073/pnas.052143799;
RA Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K.,
RA Breslow J.L.;
RT "The cholesterol-regulated StarD4 gene encodes a StAR-related lipid
RT transfer protein with two closely related homologues, StarD5 and StarD6.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-213 (ISOFORM 1).
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 6-213.
RX PubMed=21738568; DOI=10.1371/journal.pone.0019521;
RA Thorsell A.G., Lee W.H., Persson C., Siponen M.I., Nilsson M., Busam R.D.,
RA Kotenyova T., Schuler H., Lehtio L.;
RT "Comparative structural analysis of lipid binding START domains.";
RL PLoS ONE 6:E19521-E19521(2011).
CC -!- FUNCTION: May be involved in the intracellular transport of sterols or
CC other lipids. May bind cholesterol or other sterols (By similarity).
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NSY2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NSY2-3; Sequence=VSP_014871, VSP_014872;
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DR EMBL; AF480304; AAL89654.1; -; mRNA.
DR EMBL; AL137657; CAB70862.2; -; mRNA.
DR EMBL; AK026352; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC004365; AAH04365.2; -; mRNA.
DR CCDS; CCDS10318.1; -. [Q9NSY2-1]
DR PIR; T46357; T46357.
DR RefSeq; NP_871629.1; NM_181900.2. [Q9NSY2-1]
DR PDB; 2R55; X-ray; 2.50 A; A/B=6-213.
DR PDBsum; 2R55; -.
DR AlphaFoldDB; Q9NSY2; -.
DR BMRB; Q9NSY2; -.
DR SMR; Q9NSY2; -.
DR BioGRID; 123299; 4.
DR STRING; 9606.ENSP00000304032; -.
DR SwissLipids; SLP:000000715; -.
DR iPTMnet; Q9NSY2; -.
DR PhosphoSitePlus; Q9NSY2; -.
DR BioMuta; STARD5; -.
DR DMDM; 25091329; -.
DR EPD; Q9NSY2; -.
DR jPOST; Q9NSY2; -.
DR MassIVE; Q9NSY2; -.
DR PaxDb; Q9NSY2; -.
DR PeptideAtlas; Q9NSY2; -.
DR PRIDE; Q9NSY2; -.
DR ProteomicsDB; 82597; -. [Q9NSY2-1]
DR ProteomicsDB; 82598; -. [Q9NSY2-3]
DR Antibodypedia; 27966; 164 antibodies from 24 providers.
DR DNASU; 80765; -.
DR Ensembl; ENST00000302824.7; ENSP00000304032.6; ENSG00000172345.14. [Q9NSY2-1]
DR Ensembl; ENST00000325346.6; ENSP00000317519.6; ENSG00000172345.14. [Q9NSY2-3]
DR GeneID; 80765; -.
DR KEGG; hsa:80765; -.
DR MANE-Select; ENST00000302824.7; ENSP00000304032.6; NM_181900.3; NP_871629.1.
DR UCSC; uc002bgm.4; human. [Q9NSY2-1]
DR CTD; 80765; -.
DR DisGeNET; 80765; -.
DR GeneCards; STARD5; -.
DR HGNC; HGNC:18065; STARD5.
DR HPA; ENSG00000172345; Low tissue specificity.
DR MIM; 607050; gene.
DR neXtProt; NX_Q9NSY2; -.
DR OpenTargets; ENSG00000172345; -.
DR PharmGKB; PA38286; -.
DR VEuPathDB; HostDB:ENSG00000172345; -.
DR eggNOG; KOG3845; Eukaryota.
DR GeneTree; ENSGT00940000159159; -.
DR HOGENOM; CLU_093200_1_0_1; -.
DR InParanoid; Q9NSY2; -.
DR OMA; GCPPQSG; -.
DR OrthoDB; 1469639at2759; -.
DR PhylomeDB; Q9NSY2; -.
DR PathwayCommons; Q9NSY2; -.
DR Reactome; R-HSA-159418; Recycling of bile acids and salts.
DR BioGRID-ORCS; 80765; 14 hits in 1086 CRISPR screens.
DR EvolutionaryTrace; Q9NSY2; -.
DR GeneWiki; STARD5; -.
DR GenomeRNAi; 80765; -.
DR Pharos; Q9NSY2; Tbio.
DR PRO; PR:Q9NSY2; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9NSY2; protein.
DR Bgee; ENSG00000172345; Expressed in right lobe of liver and 113 other tissues.
DR ExpressionAtlas; Q9NSY2; baseline and differential.
DR Genevisible; Q9NSY2; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0032052; F:bile acid binding; IEA:InterPro.
DR GO; GO:0015485; F:cholesterol binding; IDA:BHF-UCL.
DR GO; GO:0120020; F:cholesterol transfer activity; IDA:BHF-UCL.
DR GO; GO:0070508; P:cholesterol import; IDA:BHF-UCL.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR029868; StARD5.
DR InterPro; IPR043556; StARD5/6.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR46374; PTHR46374; 1.
DR PANTHER; PTHR46374:SF3; PTHR46374:SF3; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00234; START; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Lipid transport; Lipid-binding;
KW Reference proteome; Transport.
FT CHAIN 1..213
FT /note="StAR-related lipid transfer protein 5"
FT /id="PRO_0000220669"
FT DOMAIN 1..213
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT VAR_SEQ 34..63
FT /note="NGVSVSWRPSVEFPGNLYRGEGIVYGTLEE -> VPRRRHCIWDTRGGVGLC
FT EASCWRPTSEVG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_014871"
FT VAR_SEQ 64..213
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_014872"
FT VARIANT 74
FT /note="G -> S (in dbSNP:rs4384572)"
FT /id="VAR_052071"
FT HELIX 6..22
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 28..31
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 34..42
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 44..59
FT /evidence="ECO:0007829|PDB:2R55"
FT HELIX 61..68
FT /evidence="ECO:0007829|PDB:2R55"
FT HELIX 76..79
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 84..91
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 93..102
FT /evidence="ECO:0007829|PDB:2R55"
FT TURN 107..110
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 114..124
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 130..136
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 149..153
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 155..162
FT /evidence="ECO:0007829|PDB:2R55"
FT STRAND 170..176
FT /evidence="ECO:0007829|PDB:2R55"
FT HELIX 186..209
FT /evidence="ECO:0007829|PDB:2R55"
FT HELIX 210..212
FT /evidence="ECO:0007829|PDB:2R55"
SQ SEQUENCE 213 AA; 23794 MW; EE5547A7846AB3C4 CRC64;
MDPALAAQMS EAVAEKMLQY RRDTAGWKIC REGNGVSVSW RPSVEFPGNL YRGEGIVYGT
LEEVWDCVKP AVGGLRVKWD ENVTGFEIIQ SITDTLCVSR TSTPSAAMKL ISPRDFVDLV
LVKRYEDGTI SSNATHVEHP LCPPKPGFVR GFNHPCGCFC EPLPGEPTKT NLVTFFHTDL
SGYLPQNVVD SFFPRSMTRF YANLQKAVKQ FHE
