STAR5_MOUSE
ID STAR5_MOUSE Reviewed; 213 AA.
AC Q9EPQ7; Q9CQY0; Q9EPQ6;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 15-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=StAR-related lipid transfer protein 5;
DE AltName: Full=START domain-containing protein 5;
DE Short=StARD5;
GN Name=Stard5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster / NIH;
RX PubMed=11247670; DOI=10.1006/geno.2000.6466;
RA Wines M.E., Lee L., Katari M.S., Zhang L., DeRossi C., Shi Y., Perkins S.,
RA Feldman M., McCombie W.R., Holdener B.C.;
RT "Identification of mesoderm development (mesd) candidate genes by
RT comparative mapping and genome sequence analysis.";
RL Genomics 72:88-98(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=12011452; DOI=10.1073/pnas.052143799;
RA Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K.,
RA Breslow J.L.;
RT "The cholesterol-regulated StarD4 gene encodes a StAR-related lipid
RT transfer protein with two closely related homologues, StarD5 and StarD6.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Aorta, Heart, Inner ear, Kidney, Tongue, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in the intracellular transport of sterols or
CC other lipids. May bind cholesterol or other sterols.
CC -!- TISSUE SPECIFICITY: Expressed in most tissues, with highest levels in
CC liver and in kidney.
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DR EMBL; AY007808; AAG41056.1; -; mRNA.
DR EMBL; AY007809; AAG41057.1; -; mRNA.
DR EMBL; AF480302; AAL89652.1; -; mRNA.
DR EMBL; AK009980; BAB26624.2; -; mRNA.
DR EMBL; AK080060; BAC37819.1; -; mRNA.
DR EMBL; AK085852; BAC39551.1; -; mRNA.
DR EMBL; AK142503; BAE25090.1; -; mRNA.
DR EMBL; AK158178; BAE34395.1; -; mRNA.
DR EMBL; BC058226; AAH58226.1; -; mRNA.
DR CCDS; CCDS21411.1; -.
DR RefSeq; NP_075866.2; NM_023377.4.
DR AlphaFoldDB; Q9EPQ7; -.
DR SMR; Q9EPQ7; -.
DR STRING; 10090.ENSMUSP00000074872; -.
DR iPTMnet; Q9EPQ7; -.
DR PhosphoSitePlus; Q9EPQ7; -.
DR SwissPalm; Q9EPQ7; -.
DR EPD; Q9EPQ7; -.
DR jPOST; Q9EPQ7; -.
DR MaxQB; Q9EPQ7; -.
DR PaxDb; Q9EPQ7; -.
DR PeptideAtlas; Q9EPQ7; -.
DR PRIDE; Q9EPQ7; -.
DR ProteomicsDB; 257450; -.
DR Antibodypedia; 27966; 164 antibodies from 24 providers.
DR DNASU; 170460; -.
DR Ensembl; ENSMUST00000075418; ENSMUSP00000074872; ENSMUSG00000046027.
DR GeneID; 170460; -.
DR KEGG; mmu:170460; -.
DR UCSC; uc009idq.1; mouse.
DR CTD; 80765; -.
DR MGI; MGI:2156765; Stard5.
DR VEuPathDB; HostDB:ENSMUSG00000046027; -.
DR eggNOG; KOG3845; Eukaryota.
DR GeneTree; ENSGT00940000159159; -.
DR HOGENOM; CLU_093200_1_0_1; -.
DR InParanoid; Q9EPQ7; -.
DR OMA; GCPPQSG; -.
DR OrthoDB; 1469639at2759; -.
DR PhylomeDB; Q9EPQ7; -.
DR Reactome; R-MMU-159418; Recycling of bile acids and salts.
DR BioGRID-ORCS; 170460; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Stard5; mouse.
DR PRO; PR:Q9EPQ7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9EPQ7; protein.
DR Bgee; ENSMUSG00000046027; Expressed in lip and 196 other tissues.
DR ExpressionAtlas; Q9EPQ7; baseline and differential.
DR Genevisible; Q9EPQ7; MM.
DR GO; GO:0032052; F:bile acid binding; IEA:InterPro.
DR GO; GO:0015485; F:cholesterol binding; ISA:MGI.
DR GO; GO:0120020; F:cholesterol transfer activity; ISO:MGI.
DR GO; GO:0070508; P:cholesterol import; ISO:MGI.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR000799; StAR-like.
DR InterPro; IPR029868; StARD5.
DR InterPro; IPR043556; StARD5/6.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR46374; PTHR46374; 1.
DR PANTHER; PTHR46374:SF3; PTHR46374:SF3; 1.
DR Pfam; PF01852; START; 1.
DR PRINTS; PR00978; STARPROTEIN.
DR SMART; SM00234; START; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Lipid transport; Lipid-binding; Reference proteome; Transport.
FT CHAIN 1..213
FT /note="StAR-related lipid transfer protein 5"
FT /id="PRO_0000220670"
FT DOMAIN 1..213
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
SQ SEQUENCE 213 AA; 23922 MW; B689F28F9D377209 CRC64;
MDPSWATQES EAVAEKVLRY RRDASGWKKC REGNGVSISW RPSEEFPGNL YRGEGILCGT
PEEVWDCIKP VASGLREKWD DNVSSFEIVQ SITDMLCVSR TSTPSAAMKL ISPRDFVDLV
LVKKYEDGTI SSNATHVEHP LCPPKPGFVR GFNHPCGCFC EPLPGDPNKT NLVTFFQTDL
SGYLPQSVVD SFFPRSMAEF YPNLQKAVRK FHH
