ID   STAR6_HUMAN             Reviewed;         220 AA.
AC   P59095;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   15-NOV-2002, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=StAR-related lipid transfer protein 6;
DE   AltName: Full=START domain-containing protein 6;
DE            Short=StARD6;
GN   Name=STARD6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12011452; DOI=10.1073/pnas.052143799;
RA   Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K.,
RA   Breslow J.L.;
RT   "The cholesterol-regulated StarD4 gene encodes a StAR-related lipid
RT   transfer protein with two closely related homologues, StarD5 and StarD6.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002).
CC   -!- FUNCTION: May be involved in the intracellular transport of sterols or
CC       other lipids. May bind cholesterol or other sterols (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; AF480305; AAL89655.1; -; mRNA.
DR   CCDS; CCDS11955.1; -.
DR   RefSeq; NP_631910.1; NM_139171.1.
DR   RefSeq; XP_011524123.1; XM_011525821.1.
DR   PDB; 2MOU; NMR; -; A=1-220.
DR   PDBsum; 2MOU; -.
DR   AlphaFoldDB; P59095; -.
DR   BMRB; P59095; -.
DR   SMR; P59095; -.
DR   BioGRID; 127052; 6.
DR   STRING; 9606.ENSP00000462349; -.
DR   SwissLipids; SLP:000000717; -.
DR   iPTMnet; P59095; -.
DR   PhosphoSitePlus; P59095; -.
DR   BioMuta; STARD6; -.
DR   DMDM; 25091297; -.
DR   MassIVE; P59095; -.
DR   PaxDb; P59095; -.
DR   PeptideAtlas; P59095; -.
DR   PRIDE; P59095; -.
DR   Antibodypedia; 58888; 68 antibodies from 16 providers.
DR   DNASU; 147323; -.
DR   Ensembl; ENST00000307844.4; ENSP00000310814.3; ENSG00000174448.9.
DR   Ensembl; ENST00000581310.5; ENSP00000462349.1; ENSG00000174448.9.
DR   GeneID; 147323; -.
DR   KEGG; hsa:147323; -.
DR   MANE-Select; ENST00000307844.4; ENSP00000310814.3; NM_139171.2; NP_631910.1.
DR   UCSC; uc010xdt.2; human.
DR   CTD; 147323; -.
DR   DisGeNET; 147323; -.
DR   GeneCards; STARD6; -.
DR   HGNC; HGNC:18066; STARD6.
DR   HPA; ENSG00000174448; Tissue enriched (testis).
DR   MIM; 607051; gene.
DR   neXtProt; NX_P59095; -.
DR   OpenTargets; ENSG00000174448; -.
DR   PharmGKB; PA38287; -.
DR   VEuPathDB; HostDB:ENSG00000174448; -.
DR   eggNOG; KOG3845; Eukaryota.
DR   GeneTree; ENSGT00940000161788; -.
DR   HOGENOM; CLU_093200_1_0_1; -.
DR   InParanoid; P59095; -.
DR   OMA; YNMVHKI; -.
DR   OrthoDB; 1469639at2759; -.
DR   PhylomeDB; P59095; -.
DR   PathwayCommons; P59095; -.
DR   Reactome; R-HSA-196108; Pregnenolone biosynthesis.
DR   SignaLink; P59095; -.
DR   BioGRID-ORCS; 147323; 13 hits in 1064 CRISPR screens.
DR   GenomeRNAi; 147323; -.
DR   Pharos; P59095; Tbio.
DR   PRO; PR:P59095; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; P59095; protein.
DR   Bgee; ENSG00000174448; Expressed in left testis and 68 other tissues.
DR   ExpressionAtlas; P59095; baseline and differential.
DR   Genevisible; P59095; HS.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR043556; StARD5/6.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR46374; PTHR46374; 1.
DR   Pfam; PF01852; START; 1.
DR   SMART; SM00234; START; 1.
DR   PROSITE; PS50848; START; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Lipid transport; Lipid-binding; Reference proteome;
KW   Transport.
FT   CHAIN           1..220
FT                   /note="StAR-related lipid transfer protein 6"
FT                   /id="PRO_0000220672"
FT   DOMAIN          1..208
FT                   /note="START"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT   VARIANT         159
FT                   /note="E -> K (in dbSNP:rs2917782)"
FT                   /id="VAR_024651"
FT   HELIX           3..18
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          26..29
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          31..37
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          41..45
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          48..56
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   HELIX           58..64
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          65..70
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   TURN            71..73
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          76..83
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          88..98
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          109..120
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   TURN            121..123
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          124..131
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          141..145
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          148..158
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   STRAND          161..173
FT                   /evidence="ECO:0007829|PDB:2MOU"
FT   HELIX           181..207
FT                   /evidence="ECO:0007829|PDB:2MOU"
SQ   SEQUENCE   220 AA;  25022 MW;  5AC49FFF5C953234 CRC64;
     MDFKAIAQQT AQEVLGYNRD TSGWKVVKTS KKITVSSKAS RKFHGNLYRV EGIIPESPAK
     LSDFLYQTGD RITWDKSLQV YNMVHRIDSD TFICHTITQS FAVGSISPRD FIDLVYIKRY
     EGNMNIISSK SVDFPEYPPS SNYIRGYNHP CGFVCSPMEE NPAYSKLVMF VQTEMRGKLS
     PSIIEKTMPS NLVNFILNAK DGIKAHRTPS RRGFHHNSHS