STAR6_MOUSE
ID STAR6_MOUSE Reviewed; 233 AA.
AC P59096;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 15-NOV-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=StAR-related lipid transfer protein 6;
DE AltName: Full=START domain-containing protein 6;
DE Short=StARD6;
GN Name=Stard6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=12011452; DOI=10.1073/pnas.052143799;
RA Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K.,
RA Breslow J.L.;
RT "The cholesterol-regulated StarD4 gene encodes a StAR-related lipid
RT transfer protein with two closely related homologues, StarD5 and StarD6.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in the intracellular transport of sterols or
CC other lipids. May bind cholesterol or other sterols (By similarity).
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF480303; AAL89653.1; -; mRNA.
DR EMBL; AK014759; BAB29535.2; -; mRNA.
DR CCDS; CCDS37854.1; -.
DR RefSeq; NP_001276577.1; NM_001289648.1.
DR RefSeq; NP_001276578.1; NM_001289649.1.
DR RefSeq; NP_001276579.1; NM_001289650.1.
DR RefSeq; NP_083295.1; NM_029019.4.
DR AlphaFoldDB; P59096; -.
DR SMR; P59096; -.
DR STRING; 10090.ENSMUSP00000110609; -.
DR PhosphoSitePlus; P59096; -.
DR PaxDb; P59096; -.
DR PRIDE; P59096; -.
DR ProteomicsDB; 254579; -.
DR Antibodypedia; 58888; 68 antibodies from 16 providers.
DR DNASU; 170461; -.
DR Ensembl; ENSMUST00000114959; ENSMUSP00000110609; ENSMUSG00000079608.
DR Ensembl; ENSMUST00000164223; ENSMUSP00000126055; ENSMUSG00000079608.
DR Ensembl; ENSMUST00000168249; ENSMUSP00000130991; ENSMUSG00000079608.
DR Ensembl; ENSMUST00000174118; ENSMUSP00000134511; ENSMUSG00000079608.
DR GeneID; 170461; -.
DR KEGG; mmu:170461; -.
DR UCSC; uc008fog.2; mouse.
DR CTD; 147323; -.
DR MGI; MGI:2156774; Stard6.
DR VEuPathDB; HostDB:ENSMUSG00000079608; -.
DR eggNOG; KOG3845; Eukaryota.
DR GeneTree; ENSGT00940000161788; -.
DR HOGENOM; CLU_093200_1_0_1; -.
DR InParanoid; P59096; -.
DR OMA; YNMVHKI; -.
DR OrthoDB; 1469639at2759; -.
DR PhylomeDB; P59096; -.
DR Reactome; R-MMU-196108; Pregnenolone biosynthesis.
DR BioGRID-ORCS; 170461; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Stard6; mouse.
DR PRO; PR:P59096; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; P59096; protein.
DR Bgee; ENSMUSG00000079608; Expressed in spermatid and 58 other tissues.
DR ExpressionAtlas; P59096; baseline and differential.
DR Genevisible; P59096; MM.
DR GO; GO:0015485; F:cholesterol binding; ISA:MGI.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR000799; StAR-like.
DR InterPro; IPR043556; StARD5/6.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR46374; PTHR46374; 1.
DR Pfam; PF01852; START; 1.
DR PRINTS; PR00978; STARPROTEIN.
DR SMART; SM00234; START; 1.
DR PROSITE; PS50848; START; 1.
PE 2: Evidence at transcript level;
KW Lipid transport; Lipid-binding; Reference proteome; Transport.
FT CHAIN 1..233
FT /note="StAR-related lipid transfer protein 6"
FT /id="PRO_0000220673"
FT DOMAIN 1..208
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT REGION 213..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 233 AA; 26223 MW; 2FCE6B898E99C2B5 CRC64;
MDYKAIAQQT AEQVLAYNQD LSGWKLIKSS KKVTVSSKTS RIFHGNLYRV EGIIPESAAH
LSDFLFKHDH RVSWDKSLKG FNVIHKIDSD TLICHTITQS FAMGSISPRD FIDLVHIKHY
ERNVDIISTK SVDFPGYAPT STYIRGFNHP SGYVCSPLKE NPAYSKLVIF VQTEMKGKLP
ASVIEKSMPS NLVSFLLNVK DGVKTYRIPP IRARHSSHSS VHKKKEGHSA IKP
