STAR7_HUMAN
ID STAR7_HUMAN Reviewed; 370 AA.
AC Q9NQZ5; D3DXG9; Q53T44; Q6GU43; Q969M6;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=StAR-related lipid transfer protein 7, mitochondrial;
DE AltName: Full=Gestational trophoblastic tumor protein 1;
DE AltName: Full=START domain-containing protein 7;
DE Short=StARD7;
DE Flags: Precursor;
GN Name=STARD7; Synonyms=GTT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cervix carcinoma;
RX PubMed=15013637; DOI=10.1016/s0143-4004(03)00214-5;
RA Durand S., Angeletti S., Genti-Raimondi S.;
RT "GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly
RT expressed in gestational trophoblastic tumour: cloning and
RT characterization.";
RL Placenta 25:37-44(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-140.
RC TISSUE=Brain, Lymph, Placenta, Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=25980009; DOI=10.4049/jimmunol.1500231;
RA Yang L., Lewkowich I., Apsley K., Fritz J.M., Wills-Karp M., Weaver T.E.;
RT "Haploinsufficiency for Stard7 is associated with enhanced allergic
RT responses in lung and skin.";
RL J. Immunol. 194:5635-5643(2015).
CC -!- FUNCTION: May play a protective role in mucosal tissues by preventing
CC exaggerated allergic responses. {ECO:0000250|UniProtKB:Q8R1R3}.
CC -!- INTERACTION:
CC Q9NQZ5; Q86XE5: HOGA1; NbExp=2; IntAct=EBI-4402938, EBI-9658477;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in nasal epithelial cells. Down-regulated
CC in nasal epithelial cells in patients experiencing an asthma
CC exacerbation as compared to stable asthmatics and healthy controls.
CC {ECO:0000269|PubMed:25980009}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF81750.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAH07894.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH08894.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH09998.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH12774.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH12793.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH13279.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH14076.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH14274.3; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH32106.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF270647; AAF81750.1; ALT_FRAME; mRNA.
DR EMBL; AC012307; AAY24223.1; -; Genomic_DNA.
DR EMBL; CH471207; EAW71382.1; -; Genomic_DNA.
DR EMBL; CH471207; EAW71383.1; -; Genomic_DNA.
DR EMBL; BC007894; AAH07894.1; ALT_INIT; mRNA.
DR EMBL; BC008894; AAH08894.1; ALT_INIT; mRNA.
DR EMBL; BC009998; AAH09998.1; ALT_INIT; mRNA.
DR EMBL; BC012774; AAH12774.1; ALT_INIT; mRNA.
DR EMBL; BC012793; AAH12793.1; ALT_INIT; mRNA.
DR EMBL; BC013279; AAH13279.1; ALT_INIT; mRNA.
DR EMBL; BC014076; AAH14076.1; ALT_INIT; mRNA.
DR EMBL; BC014274; AAH14274.3; ALT_INIT; mRNA.
DR EMBL; BC032106; AAH32106.1; ALT_INIT; mRNA.
DR CCDS; CCDS2017.2; -.
DR RefSeq; NP_064536.2; NM_020151.3.
DR AlphaFoldDB; Q9NQZ5; -.
DR SMR; Q9NQZ5; -.
DR BioGRID; 121238; 31.
DR IntAct; Q9NQZ5; 28.
DR STRING; 9606.ENSP00000338030; -.
DR ChEMBL; CHEMBL3399912; -.
DR TCDB; 8.A.120.1.1; the mitochondrial star-related lipid transfer protein (star) family.
DR iPTMnet; Q9NQZ5; -.
DR PhosphoSitePlus; Q9NQZ5; -.
DR BioMuta; STARD7; -.
DR DMDM; 215273945; -.
DR EPD; Q9NQZ5; -.
DR jPOST; Q9NQZ5; -.
DR MassIVE; Q9NQZ5; -.
DR MaxQB; Q9NQZ5; -.
DR PaxDb; Q9NQZ5; -.
DR PeptideAtlas; Q9NQZ5; -.
DR PRIDE; Q9NQZ5; -.
DR ProteomicsDB; 82233; -.
DR Antibodypedia; 32404; 154 antibodies from 22 providers.
DR DNASU; 56910; -.
DR Ensembl; ENST00000337288.10; ENSP00000338030.5; ENSG00000084090.14.
DR GeneID; 56910; -.
DR KEGG; hsa:56910; -.
DR MANE-Select; ENST00000337288.10; ENSP00000338030.5; NM_020151.4; NP_064536.2.
DR UCSC; uc002svm.6; human.
DR CTD; 56910; -.
DR DisGeNET; 56910; -.
DR GeneCards; STARD7; -.
DR HGNC; HGNC:18063; STARD7.
DR HPA; ENSG00000084090; Low tissue specificity.
DR MalaCards; STARD7; -.
DR MIM; 616712; gene.
DR neXtProt; NX_Q9NQZ5; -.
DR OpenTargets; ENSG00000084090; -.
DR PharmGKB; PA38285; -.
DR VEuPathDB; HostDB:ENSG00000084090; -.
DR eggNOG; KOG2761; Eukaryota.
DR GeneTree; ENSGT00940000157856; -.
DR HOGENOM; CLU_042209_0_0_1; -.
DR InParanoid; Q9NQZ5; -.
DR OMA; MFPRRPP; -.
DR OrthoDB; 973910at2759; -.
DR PhylomeDB; Q9NQZ5; -.
DR TreeFam; TF320705; -.
DR PathwayCommons; Q9NQZ5; -.
DR Reactome; R-HSA-1483191; Synthesis of PC.
DR SignaLink; Q9NQZ5; -.
DR BioGRID-ORCS; 56910; 259 hits in 1080 CRISPR screens.
DR ChiTaRS; STARD7; human.
DR GeneWiki; STARD7; -.
DR GenomeRNAi; 56910; -.
DR Pharos; Q9NQZ5; Tbio.
DR PRO; PR:Q9NQZ5; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9NQZ5; protein.
DR Bgee; ENSG00000084090; Expressed in secondary oocyte and 207 other tissues.
DR ExpressionAtlas; Q9NQZ5; baseline and differential.
DR Genevisible; Q9NQZ5; HS.
DR GO; GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR CDD; cd08911; START_STARD7-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR InterPro; IPR041949; START_STARD7.
DR Pfam; PF01852; START; 1.
DR SMART; SM00234; START; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..58
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 59..370
FT /note="StAR-related lipid transfer protein 7,
FT mitochondrial"
FT /id="PRO_0000220674"
FT DOMAIN 112..327
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT REGION 111..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..111
FT /evidence="ECO:0000255"
FT COMPBIAS 344..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 140
FT /note="R -> P (in dbSNP:rs2276650)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_020345"
FT CONFLICT 72..73
FT /note="Missing (in Ref. 1; AAF81750)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 370 AA; 43113 MW; 2E7CDD6CC504D86C CRC64;
MLPRRLLAAW LAGTRGGGLL ALLANQCRFV TGLRVRRAQQ IAQLYGRLYS ESSRRVLLGR
LWRRLHGRPG HASALMAALA GVFVWDEERI QEEELQRSIN EMKRLEEMSN MFQSSGVQHH
PPEPKAQTEG NEDSEGKEQR WEMVMDKKHF KLWRRPITGT HLYQYRVFGT YTDVTPRQFF
NVQLDTEYRK KWDALVIKLE VIERDVVSGS EVLHWVTHFP YPMYSRDYVY VRRYSVDQEN
NMMVLVSRAV EHPSVPESPE FVRVRSYESQ MVIRPHKSFD ENGFDYLLTY SDNPQTVFPR
YCVSWMVSSG MPDFLEKLHM ATLKAKNMEI KVKDYISAKP LEMSSEAKAT SQSSERKNEG
SCGPARIEYA
