STAR7_MOUSE
ID STAR7_MOUSE Reviewed; 373 AA.
AC Q8R1R3; A2ARG0;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=StAR-related lipid transfer protein 7, mitochondrial;
DE AltName: Full=START domain-containing protein 7;
DE Short=StARD7;
DE Flags: Precursor;
GN Name=Stard7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=25980009; DOI=10.4049/jimmunol.1500231;
RA Yang L., Lewkowich I., Apsley K., Fritz J.M., Wills-Karp M., Weaver T.E.;
RT "Haploinsufficiency for Stard7 is associated with enhanced allergic
RT responses in lung and skin.";
RL J. Immunol. 194:5635-5643(2015).
CC -!- FUNCTION: May play a protective role in mucosal tissues by preventing
CC exaggerated allergic responses. {ECO:0000269|PubMed:25980009}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in epithelial cells of airways,
CC peripheral bronchioles and alveoli, as well as in the basal cell layer
CC of the epidermis (at protein level). {ECO:0000269|PubMed:25980009}.
CC -!- DISRUPTION PHENOTYPE: The viability of homozygous knockout embryos is
CC dramatically decreased after 10.0 dpc. Surviving animals have a normal
CC life expectancy, but males are infertile. Ovalbumin sensitization and
CC challenge of heterozygous mice results in a significant increase in
CC pulmonary inflammation, mucous cell metaplasia, airway
CC hyperresponsiveness and ovalbumin-specific IgE compared with wild-type
CC animals. This exacerbation is associated with an increase in CD4(+)
CC IL13(+) T helper cells, as well as an increase IL4, IL5 and IL13
CC cytokine production in lungs. Sensitized and/or challenged mutant
CC animals show an increased lung epithelial permeability and activation
CC of pro-inflammatory dendritic cells. At 6-7 months of age, about 30% of
CC heterozygous mice develop skin lesions, with significant thickening of
CC the epidermis, including the cornified layer, predominately on the ears
CC and back. Lesions are accompanied by vigorous scratching. In the
CC lesions, IL4, IL5 and IL13 cytokine production is increased and serum
CC IgE levels are up-regulated at the time of appearance of skin lesions.
CC {ECO:0000269|PubMed:25980009}.
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DR EMBL; AL845368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017524; AAH17524.2; -; mRNA.
DR CCDS; CCDS16698.2; -.
DR RefSeq; NP_647469.2; NM_139308.2.
DR AlphaFoldDB; Q8R1R3; -.
DR SMR; Q8R1R3; -.
DR BioGRID; 221192; 1.
DR STRING; 10090.ENSMUSP00000106004; -.
DR iPTMnet; Q8R1R3; -.
DR PhosphoSitePlus; Q8R1R3; -.
DR MaxQB; Q8R1R3; -.
DR PaxDb; Q8R1R3; -.
DR PRIDE; Q8R1R3; -.
DR ProteomicsDB; 258750; -.
DR Antibodypedia; 32404; 154 antibodies from 22 providers.
DR DNASU; 99138; -.
DR Ensembl; ENSMUST00000110375; ENSMUSP00000106004; ENSMUSG00000027367.
DR GeneID; 99138; -.
DR KEGG; mmu:99138; -.
DR UCSC; uc008mfe.2; mouse.
DR CTD; 56910; -.
DR MGI; MGI:2139090; Stard7.
DR VEuPathDB; HostDB:ENSMUSG00000027367; -.
DR eggNOG; KOG2761; Eukaryota.
DR GeneTree; ENSGT00940000157856; -.
DR InParanoid; Q8R1R3; -.
DR OMA; MFPRRPP; -.
DR OrthoDB; 973910at2759; -.
DR TreeFam; TF320705; -.
DR Reactome; R-MMU-1483191; Synthesis of PC.
DR BioGRID-ORCS; 99138; 13 hits in 74 CRISPR screens.
DR ChiTaRS; Stard7; mouse.
DR PRO; PR:Q8R1R3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8R1R3; protein.
DR Bgee; ENSMUSG00000027367; Expressed in retinal neural layer and 255 other tissues.
DR ExpressionAtlas; Q8R1R3; baseline and differential.
DR Genevisible; Q8R1R3; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0061436; P:establishment of skin barrier; IMP:MGI.
DR GO; GO:0006954; P:inflammatory response; IMP:MGI.
DR GO; GO:0120197; P:mucociliary clearance; IMP:MGI.
DR GO; GO:0001773; P:myeloid dendritic cell activation; IMP:MGI.
DR GO; GO:0042092; P:type 2 immune response; IMP:MGI.
DR CDD; cd08911; START_STARD7-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR InterPro; IPR041949; START_STARD7.
DR Pfam; PF01852; START; 1.
DR SMART; SM00234; START; 1.
DR PROSITE; PS50848; START; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..61
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 62..373
FT /note="StAR-related lipid transfer protein 7,
FT mitochondrial"
FT /id="PRO_0000220675"
FT DOMAIN 115..330
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT REGION 118..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 89..114
FT /evidence="ECO:0000255"
SQ SEQUENCE 373 AA; 43144 MW; 6DB7E4EAA63A2838 CRC64;
MFPRRPPATL AAWLAGARGG GLLSALANQC RFVTGLRVRR AQQIAQLYGR LYSESSRCAL
LGRFWRRLRG RPGHASVLMA ALSGVFVWDE ERIQEEELQR SINEMKRLEE MSNIFQSSGV
ENYPPEPKSP AGGNEKSKDK EEPWEMVMDK KHFKLWRRPI TGTHLYQYRV FGTYTDVTPR
QFFNVQLDTE YRKKWDALVI KLEVIERDAV SGSEVLHWVT HFPYPMYSRD YVYVRRYSVD
QENNVMVLVS RAVEHPSVPE SPEFVRVRSY ESQMVIRPHK SFDENGFDYL LTYSDNPQTV
FPRYCVSWMV SSGMPDFLEK LHMATLKAKN MEIKVKDYIS AKPLEMSSEA KATAPSPERK
NEGSCGPARI EYA
