ID   STAR_CHICK              Reviewed;         281 AA.
AC   Q9DG09;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Steroidogenic acute regulatory protein, mitochondrial;
DE            Short=StAR;
DE   AltName: Full=START domain-containing protein 1;
DE            Short=StARD1;
DE   Flags: Precursor;
GN   Name=STAR;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=11064158; DOI=10.1016/s0303-7207(00)00316-6;
RA   Bauer M.P., Bridgham J.T., Langenau D.M., Johnson A.L., Goetz F.W.;
RT   "Conservation of steroidogenic acute regulatory (StAR) protein structure
RT   and expression in vertebrates.";
RL   Mol. Cell. Endocrinol. 168:119-125(2000).
CC   -!- FUNCTION: Plays a key role in steroid hormone synthesis by enhancing
CC       the metabolism of cholesterol into pregnenolone. Mediates the transfer
CC       of cholesterol from the outer mitochondrial membrane to the inner
CC       mitochondrial membrane where it is cleaved to pregnenolone (By
CC       similarity). {ECO:0000250|UniProtKB:P49675}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC         ChEBI:CHEBI:16113; Evidence={ECO:0000250|UniProtKB:P49675};
CC   -!- PATHWAY: Steroid metabolism; cholesterol metabolism.
CC       {ECO:0000250|UniProtKB:P49675}.
CC   -!- SUBUNIT: May interact with TSPO. {ECO:0000250|UniProtKB:P79245}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P51557}.
CC   -!- TISSUE SPECIFICITY: Expressed principally in steroidogenic tissues as
CC       ovary (granulosa from the largest preovulatory follicle and stromal
CC       tissues) and adrenals.
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DR   EMBL; AF220436; AAG28594.1; -; mRNA.
DR   RefSeq; NP_990017.1; NM_204686.2.
DR   AlphaFoldDB; Q9DG09; -.
DR   SMR; Q9DG09; -.
DR   STRING; 9031.ENSGALP00000005119; -.
DR   PaxDb; Q9DG09; -.
DR   Ensembl; ENSGALT00000005128; ENSGALP00000005119; ENSGALG00000003242.
DR   GeneID; 395421; -.
DR   KEGG; gga:395421; -.
DR   CTD; 6770; -.
DR   VEuPathDB; HostDB:geneid_395421; -.
DR   eggNOG; KOG3845; Eukaryota.
DR   GeneTree; ENSGT00940000155477; -.
DR   HOGENOM; CLU_093200_1_0_1; -.
DR   InParanoid; Q9DG09; -.
DR   OMA; KMPEQKG; -.
DR   OrthoDB; 1437203at2759; -.
DR   PhylomeDB; Q9DG09; -.
DR   TreeFam; TF313869; -.
DR   Reactome; R-GGA-196108; Pregnenolone biosynthesis.
DR   UniPathway; UPA00296; -.
DR   PRO; PR:Q9DG09; -.
DR   Proteomes; UP000000539; Chromosome 22.
DR   Bgee; ENSGALG00000003242; Expressed in testis and 7 other tissues.
DR   ExpressionAtlas; Q9DG09; baseline and differential.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR   GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR   GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032367; P:intracellular cholesterol transport; IBA:GO_Central.
DR   GO; GO:0050810; P:regulation of steroid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006694; P:steroid biosynthetic process; IBA:GO_Central.
DR   CDD; cd08905; START_STARD1-like; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR029866; StAR.
DR   InterPro; IPR000799; StAR-like.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR46489; PTHR46489; 1.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   SMART; SM00234; START; 1.
DR   PROSITE; PS50848; START; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Lipid-binding; Mitochondrion; Reference proteome;
KW   Steroidogenesis; Transit peptide; Transport.
FT   TRANSIT         1..63
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           64..281
FT                   /note="Steroidogenic acute regulatory protein,
FT                   mitochondrial"
FT                   /id="PRO_0000033322"
FT   DOMAIN          67..280
FT                   /note="START"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
SQ   SEQUENCE   281 AA;  31036 MW;  96B0B43616BD8A37 CRC64;
     MLPATFKLCA AISYQHLRNV TGLRRQAAVA ISQELSKLSC RSTGPSTWIS QVRRRSSLLS
     SRLEEKPFSE MEMSYIKQGE EALQKSLSIL GDQEGWKTET VADNGDKVLS KVLPDVGKVF
     RLEVVVDQPL DAVYSELVDN MEQMGDWNPS VKEVKILQRV GKDTLITHET AAAPPGNIVG
     PRDFVSVRCS RRRGSTCVLA GMSTTHGAMP EQQGFIRAEN GPTCMVLRPL AGSPSQTKLT
     WLLSIDLKGW LPKTIINQVL SQTQVDFAKH LRQRMARAAG C