ID   STAR_DANRE              Reviewed;         285 AA.
AC   Q9DG10;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Steroidogenic acute regulatory protein, mitochondrial;
DE            Short=StAR;
DE   AltName: Full=START domain-containing protein 1;
DE            Short=StARD1;
DE   Flags: Precursor;
GN   Name=star;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11064158; DOI=10.1016/s0303-7207(00)00316-6;
RA   Bauer M.P., Bridgham J.T., Langenau D.M., Johnson A.L., Goetz F.W.;
RT   "Conservation of steroidogenic acute regulatory (StAR) protein structure
RT   and expression in vertebrates.";
RL   Mol. Cell. Endocrinol. 168:119-125(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a key role in steroid hormone synthesis by enhancing
CC       the metabolism of cholesterol into pregnenolone. Mediates the transfer
CC       of cholesterol from the outer mitochondrial membrane to the inner
CC       mitochondrial membrane where it is cleaved to pregnenolone (By
CC       similarity). {ECO:0000250|UniProtKB:P49675}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC         ChEBI:CHEBI:16113; Evidence={ECO:0000250|UniProtKB:P49675};
CC   -!- PATHWAY: Steroid metabolism; cholesterol metabolism.
CC       {ECO:0000250|UniProtKB:P49675}.
CC   -!- SUBUNIT: May interact with TSPO. {ECO:0000250|UniProtKB:P79245}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P51557}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the testis and at lower levels
CC       in the ovary, kidney and head.
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DR   EMBL; AF220435; AAG28593.1; -; mRNA.
DR   EMBL; BC075967; AAH75967.1; -; mRNA.
DR   RefSeq; NP_571738.1; NM_131663.1.
DR   AlphaFoldDB; Q9DG10; -.
DR   SMR; Q9DG10; -.
DR   STRING; 7955.ENSDARP00000023907; -.
DR   PaxDb; Q9DG10; -.
DR   Ensembl; ENSDART00000016225; ENSDARP00000023907; ENSDARG00000006137.
DR   GeneID; 63999; -.
DR   KEGG; dre:63999; -.
DR   CTD; 6770; -.
DR   ZFIN; ZDB-GENE-001120-3; star.
DR   eggNOG; KOG3845; Eukaryota.
DR   GeneTree; ENSGT00940000155477; -.
DR   HOGENOM; CLU_093200_1_0_1; -.
DR   InParanoid; Q9DG10; -.
DR   OMA; KMPEQKG; -.
DR   OrthoDB; 1437203at2759; -.
DR   PhylomeDB; Q9DG10; -.
DR   TreeFam; TF313869; -.
DR   Reactome; R-DRE-196108; Pregnenolone biosynthesis.
DR   UniPathway; UPA00296; -.
DR   PRO; PR:Q9DG10; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000006137; Expressed in testis and 18 other tissues.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR   GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR   GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032367; P:intracellular cholesterol transport; IBA:GO_Central.
DR   GO; GO:0001556; P:oocyte maturation; IMP:ZFIN.
DR   GO; GO:0050810; P:regulation of steroid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd08905; START_STARD1-like; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR029866; StAR.
DR   InterPro; IPR000799; StAR-like.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR46489; PTHR46489; 1.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   SMART; SM00234; START; 1.
DR   PROSITE; PS50848; START; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Lipid-binding; Mitochondrion; Reference proteome;
KW   Steroidogenesis; Transit peptide; Transport.
FT   TRANSIT         1..61
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           62..285
FT                   /note="Steroidogenic acute regulatory protein,
FT                   mitochondrial"
FT                   /id="PRO_0000033323"
FT   DOMAIN          65..278
FT                   /note="START"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
SQ   SEQUENCE   285 AA;  31759 MW;  3F7C51CD77716078 CRC64;
     MLPATFKLCA GISYRHMRNM TGLRKNAMIA IHHELNKLSG PGASTWINHI RRRSSLLSSP
     IAEETYSEAD QCYVQQGQEA LQKSISILED QDGWQTEIES INGEKVMSKV LPGIGKVFKL
     EVTLEQQTGD LYDELVDNME QMGEWNPNVK QVKILQKIGQ ETMITHEISA ETPGNVVGPR
     DFVNVRHAKR RGSTCFLAGM STQHPGMPEQ KGFVRAENGP TCIVMRPSAD DPNKTKFTWL
     LSLDLKGWIP KTVINRVLSQ TQVDFVNHLR DRMASGGGID AAIAC