STAR_DROME
ID STAR_DROME Reviewed; 597 AA.
AC P42519; Q9VPW0;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Protein Star;
GN Name=S; ORFNames=CG4385;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=7924981; DOI=10.1242/dev.120.7.1731;
RA Kolodkin A.L., Pickup A.T., Lin D., Goodman C.S., Banerjee U.;
RT "Characterization of Star and its interactions with sevenless and EGF
RT receptor during photoreceptor cell development in Drosophila.";
RL Development 120:1731-1745(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION.
RX PubMed=11672524; DOI=10.1016/s0092-8674(01)00526-8;
RA Lee J.R., Urban S., Garvey C.F., Freeman M.;
RT "Regulated intracellular ligand transport and proteolysis control EGF
RT signal activation in Drosophila.";
RL Cell 107:161-171(2001).
RN [6]
RP REVIEW.
RX PubMed=11790319; DOI=10.1016/s0960-9822(01)00642-x;
RA Klaembt C.;
RT "EGF receptor signalling: roles of Star and Rhomboid revealed.";
RL Curr. Biol. 12:R21-R23(2002).
CC -!- FUNCTION: Involved in EGF receptor signaling. Has an early role in
CC photoreceptor development. Interacts with the receptor torpedo in the
CC eye. {ECO:0000269|PubMed:11672524, ECO:0000269|PubMed:7924981}.
CC -!- SUBUNIT: Interacts with Spitz via the lumenal domain and mediates its
CC transport to the Golgi.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type
CC II membrane protein. Golgi apparatus membrane; Single-pass type II
CC membrane protein. Cell membrane; Single-pass type II membrane protein.
CC -!- TISSUE SPECIFICITY: In the larval eye disk, expression is first seen at
CC the morphogenetic furrow, then in the developing R2, R5, and R8 cells
CC as well as in the posterior clusters of the disk in additional R cells.
CC {ECO:0000269|PubMed:7924981}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos and larvae.
CC {ECO:0000269|PubMed:7924981}.
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DR EMBL; L31886; AAB04161.1; -; mRNA.
DR EMBL; AE014134; AAF51425.1; -; Genomic_DNA.
DR EMBL; AY113201; AAM29206.1; -; mRNA.
DR RefSeq; NP_523450.1; NM_078726.4.
DR RefSeq; NP_722674.1; NM_164403.2.
DR AlphaFoldDB; P42519; -.
DR BioGRID; 59534; 52.
DR DIP; DIP-22174N; -.
DR IntAct; P42519; 5.
DR MINT; P42519; -.
DR STRING; 7227.FBpp0077658; -.
DR PaxDb; P42519; -.
DR DNASU; 33281; -.
DR EnsemblMetazoa; FBtr0077993; FBpp0077658; FBgn0003310.
DR EnsemblMetazoa; FBtr0077994; FBpp0077659; FBgn0003310.
DR GeneID; 33281; -.
DR KEGG; dme:Dmel_CG4385; -.
DR CTD; 33281; -.
DR FlyBase; FBgn0003310; S.
DR VEuPathDB; VectorBase:FBgn0003310; -.
DR eggNOG; ENOG502S385; Eukaryota.
DR HOGENOM; CLU_457313_0_0_1; -.
DR InParanoid; P42519; -.
DR OMA; YDETDHV; -.
DR OrthoDB; 696505at2759; -.
DR PhylomeDB; P42519; -.
DR SignaLink; P42519; -.
DR BioGRID-ORCS; 33281; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33281; -.
DR PRO; PR:P42519; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0003310; Expressed in cleaving embryo and 73 other tissues.
DR ExpressionAtlas; P42519; baseline and differential.
DR Genevisible; P42519; DM.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:FlyBase.
DR GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:FlyBase.
DR GO; GO:0031902; C:late endosome membrane; IDA:FlyBase.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR GO; GO:0048149; P:behavioral response to ethanol; IMP:FlyBase.
DR GO; GO:0001751; P:compound eye photoreceptor cell differentiation; IMP:FlyBase.
DR GO; GO:0046667; P:compound eye retinal cell programmed cell death; IMP:FlyBase.
DR GO; GO:0048263; P:determination of dorsal identity; IMP:FlyBase.
DR GO; GO:0035225; P:determination of genital disc primordium; IMP:FlyBase.
DR GO; GO:0046843; P:dorsal appendage formation; IMP:FlyBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IDA:FlyBase.
DR GO; GO:0016197; P:endosomal transport; IDA:FlyBase.
DR GO; GO:0038004; P:epidermal growth factor receptor ligand maturation; IDA:FlyBase.
DR GO; GO:0061331; P:epithelial cell proliferation involved in Malpighian tubule morphogenesis; IMP:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0007474; P:imaginal disc-derived wing vein specification; IMP:FlyBase.
DR GO; GO:0016318; P:ommatidial rotation; IMP:FlyBase.
DR GO; GO:0043703; P:photoreceptor cell fate determination; IGI:FlyBase.
DR GO; GO:0050714; P:positive regulation of protein secretion; IDA:FlyBase.
DR GO; GO:0042749; P:regulation of circadian sleep/wake cycle; IGI:FlyBase.
DR GO; GO:0048865; P:stem cell fate commitment; IMP:FlyBase.
DR GO; GO:0007421; P:stomatogastric nervous system development; IMP:FlyBase.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
PE 2: Evidence at transcript level;
KW Cell membrane; Developmental protein; Endoplasmic reticulum;
KW Golgi apparatus; Membrane; Reference proteome; Sensory transduction;
KW Signal-anchor; Transmembrane; Transmembrane helix; Vision.
FT CHAIN 1..597
FT /note="Protein Star"
FT /id="PRO_0000072241"
FT TOPO_DOM 1..279
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..597
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..243
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 65818 MW; 46B0A2F18B14486B CRC64;
MSQQVFSAHP ALAVDQLQQA EQEEHNTSSN HHQQRSATQS RRHTKAAPKK FTLSRSCAGG
GSGTLSGVHQ QVKPSPSNPA ISPECRKTLP VRTNYAAVDD DDDIECEDVD EVNFGQQEKE
RERETRQPTK DCGTDETDHV QQRHKNTMTT SATAASRHHH QDGGGGDQSD LSSVISSPSV
STVSSPLSTP TRLPQALQQQ LHCCQKSTGM ESRARTSPQQ IQHPHRQHHQ QQHHHHHHHH
HLTAAGCTGG GGGGGGSGGS GSCKAKKLDP RLNPSPYRQL LPIALCLLSF AAVFATLIVY
MDTTEIRHQQ FRLNMSRDYE LNGVAQDDPA LIDFLRQIHM GKYLGKASPK VAAAASVGVG
PPPNSPRLAA AGSTFGSGNS SGSGADQLAH YVADLVGGKM NGAVIQSLSG PLAHLITAPW
LSEQLNWMGV LVEPEPRWYF TLRKQNAQRA RMQVVHACVS PNTYPKEITI HNEDVRINSL
HDEETSWFNS RVKCFPLYTI MLACERTEYD LLSLGVQGHE LEILQTLPFD KVKIDVISIH
LLEDHEDVAD YVLDITRFLA GKSYKLQRKI GRNYFYQRLN ASASRTRKKD ILLLKTP
