ID   STAR_MESAU              Reviewed;         284 AA.
AC   P70114;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Steroidogenic acute regulatory protein, mitochondrial;
DE            Short=StAR;
DE   AltName: Full=START domain-containing protein 1;
DE            Short=StARD1;
DE   Flags: Precursor;
GN   Name=STAR;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Adrenal gland;
RX   PubMed=8969905; DOI=10.1080/07435809609043740;
RA   Fleury A., Cloutier M., Ducharme L., Lefebvre A., LeHoux J., Lehoux J.-G.;
RT   "Adrenocorticotropin regulates the level of the steroidogenic acute
RT   regulatory (StAR) protein mRNA in hamster adrenals.";
RL   Endocr. Res. 22:515-520(1996).
CC   -!- FUNCTION: Plays a key role in steroid hormone synthesis by enhancing
CC       the metabolism of cholesterol into pregnenolone. Mediates the transfer
CC       of cholesterol from the outer mitochondrial membrane to the inner
CC       mitochondrial membrane where it is cleaved to pregnenolone (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Steroid metabolism; cholesterol metabolism.
CC   -!- SUBUNIT: May interact with TSPO. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
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DR   EMBL; U66490; AAB06763.1; -; mRNA.
DR   RefSeq; NP_001268611.1; NM_001281682.1.
DR   AlphaFoldDB; P70114; -.
DR   SMR; P70114; -.
DR   STRING; 10036.XP_005066631.1; -.
DR   iPTMnet; P70114; -.
DR   PRIDE; P70114; -.
DR   GeneID; 101844174; -.
DR   CTD; 6770; -.
DR   eggNOG; KOG3845; Eukaryota.
DR   OrthoDB; 1437203at2759; -.
DR   UniPathway; UPA00296; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR   GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR   GO; GO:0044255; P:cellular lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008211; P:glucocorticoid metabolic process; IEA:Ensembl.
DR   GO; GO:0070859; P:positive regulation of bile acid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd08905; START_STARD1-like; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR029866; StAR.
DR   InterPro; IPR000799; StAR-like.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR46489; PTHR46489; 1.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   SMART; SM00234; START; 1.
DR   PROSITE; PS50848; START; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Lipid-binding; Mitochondrion; Phosphoprotein;
KW   Reference proteome; Steroidogenesis; Transit peptide; Transport.
FT   TRANSIT         1..62
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           63..284
FT                   /note="Steroidogenic acute regulatory protein,
FT                   mitochondrial"
FT                   /id="PRO_0000033317"
FT   DOMAIN          66..279
FT                   /note="START"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT   MOD_RES         56
FT                   /note="Phosphoserine; by PKA"
FT                   /evidence="ECO:0000250|UniProtKB:P49675"
FT   MOD_RES         194
FT                   /note="Phosphoserine; by PKA"
FT                   /evidence="ECO:0000250|UniProtKB:P49675"
SQ   SEQUENCE   284 AA;  31497 MW;  F238151F9EC8512B CRC64;
     MLLATFKLCA GSSYRHLRNM KGLRHQAVLA IGQELNRRTL GDSSPGWISQ VRRRSSLLGS
     QLEAALYSEQ ELSYIQQGEV AMQKALSILS NQEGWKKENQ QENGDEVLSK VVPDVGKVFR
     LEVVVDQPMD RLYAELVDRM EAMGEWNPNV KEIKVLQKIG KDTVITHELA AAAAGNLVGP
     RDFVSVRCAK RRGSTCVLAG IATHFGEMPE QSGVIRAEQG PTCMVLHPLA GSPSKTKFTW
     LLSIDLKGWL PKSIINQVLS QTQMEFANHL RKRLESSSAS EARC