ID   STAR_SALAL              Reviewed;          73 AA.
AC   P58864;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Steroidogenic acute regulatory protein;
DE            Short=StAR;
DE   AltName: Full=START domain-containing protein 1;
DE            Short=StARD1;
DE   Flags: Fragment;
GN   Name=star;
OS   Salvelinus alpinus (Arctic char) (Salmo alpinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salvelinus.
OX   NCBI_TaxID=8036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Olsson P.-E.;
RT   "Expression and regulation of FTZ-F1 and steroidogenic genes during
RT   development and reproduction in Arctic char (Salvelinus alpinus).";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a key role in steroid hormone synthesis by enhancing
CC       the metabolism of cholesterol into pregnenolone. Mediates the transfer
CC       of cholesterol from the outer mitochondrial membrane to the inner
CC       mitochondrial membrane where it is cleaved to pregnenolone (By
CC       similarity). {ECO:0000250|UniProtKB:P49675}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC         ChEBI:CHEBI:16113; Evidence={ECO:0000250|UniProtKB:P49675};
CC   -!- PATHWAY: Steroid metabolism; cholesterol metabolism.
CC       {ECO:0000250|UniProtKB:P49675}.
CC   -!- SUBUNIT: May interact with TSPO. {ECO:0000250|UniProtKB:P79245}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P51557}.
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DR   EMBL; AF468973; AAL85307.1; -; mRNA.
DR   AlphaFoldDB; P58864; -.
DR   SMR; P58864; -.
DR   UniPathway; UPA00296; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0015485; F:cholesterol binding; IEA:InterPro.
DR   GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR029866; StAR.
DR   InterPro; IPR000799; StAR-like.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR46489; PTHR46489; 1.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   PROSITE; PS50848; START; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Lipid-binding; Mitochondrion; Steroidogenesis; Transport.
FT   CHAIN           <1..73
FT                   /note="Steroidogenic acute regulatory protein"
FT                   /id="PRO_0000220650"
FT   DOMAIN          <1..65
FT                   /note="START"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT   NON_TER         1
SQ   SEQUENCE   73 AA;  8199 MW;  07E4BCE87947C5CC CRC64;
     VRAENGPTCI VMRPSADDPN KTKFTWLLSI DLKGWIPKTI INKVLSQTQV DFANHLRQRM
     ADNSVSKEMA PAC